Progress towards a public chemogenomic set for protein kinases and a call for contributions von Drewry, David H, Wells, Carrow I, Andrews, David M, Angell, Richard, Al-Ali, Hassan, Axtman, Alison D, Capuzzi, Stephen J, Elkins, Jonathan M, Ettmayer, Peter, Frederiksen, Mathias, Gileadi, Opher, Gray, Nathanael, Hooper, Alice, Knapp, Stefan, Laufer, Stefan, Luecking, Ulrich, Michaelides, Michael, Müller, Susanne, Muratov, Eugene, Denny, R Aldrin, Saikatendu, Kumar S, Treiber, Daniel K, Zuercher, William J, Willson, Timothy M

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Quantifying CDK inhibitor selectivity in live cells von Wells, Carrow I., Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Ingold, Morgan R., Pickett, Julie E., Drewry, David H., Pugh, Kathryn M., Schwinn, Marie K., Hwang, Byounghoon (Brian), Zegzouti, Hicham, Huber, Kilian V. M., Cong, Mei, Meisenheimer, Poncho L., Willson, Timothy M., Robers, Matthew B.

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice von Zhang, Y, Lee, F.Y, Barrera, G, Lee, H, Vales, C, Gonzalez, F.J, Willson, T.M, Edwards, P.A

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A data science roadmap for open science organizations engaged in early-stage drug discovery von Edfeldt, Kristina, Edwards, Aled M., Engkvist, Ola, Günther, Judith, Hartley, Matthew, Hulcoop, David G., Leach, Andrew R., Marsden, Brian D., Menge, Amelie, Misquitta, Leonie, Müller, Susanne, Owen, Dafydd R., Schütt, Kristof T., Skelton, Nicholas, Steffen, Andreas, Tropsha, Alexander, Vernet, Erik, Wang, Yanli, Wellnitz, James, Willson, Timothy M., Clevert, Djork-Arné, Haibe-Kains, Benjamin, Schiavone, Lovisa Holmberg, Schapira, Matthieu

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells von Yang, Xuan, Smith, Jeffery L, Beck, Michael T, Wilkinson, Jennifer M, Michaud, Ani, Vasta, James D, Robers, Matthew B, Willson, Timothy M

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The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism von Kliewer, Steven A, Goodwin, Bryan, Willson, Timothy M

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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK) von Asquith, Christopher R. M, Berger, Benedict-Tilman, Wan, Jing, Bennett, James M, Capuzzi, Stephen J, Crona, Daniel J, Drewry, David H, East, Michael P, Elkins, Jonathan M, Fedorov, Oleg, Godoi, Paulo H, Hunter, Debra M, Knapp, Stefan, Müller, Susanne, Torrice, Chad D, Wells, Carrow I, Earp, H. Shelton, Willson, Timothy M, Zuercher, William J

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Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds von Korshunova, Maria, Huang, Niles, Capuzzi, Stephen, Radchenko, Dmytro S., Savych, Olena, Moroz, Yuriy S., Wells, Carrow I., Willson, Timothy M., Tropsha, Alexander, Isayev, Olexandr

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Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2 von Ong, Han Wee, Yang, Xuan, Smith, Jeffery L, Taft-Benz, Sharon, Howell, Stefanie, Dickmander, Rebekah J, Havener, Tammy M, Sanders, Marcia K, Brown, Jason W, Couñago, Rafael M, Chang, Edcon, Krämer, Andreas, Moorman, Nathaniel J, Heise, Mark, Axtman, Alison D, Drewry, David H, Willson, Timothy M

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Identification of Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors von Ghoshal, Anirban, Magalhães, Álvaro F, Asressu, Kesatebrhan Haile, Hossain, Mohammad Anwar, Todd, Matthew H, Willson, Timothy M

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In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds von O'Byrne, Sean N, Scott, John W, Pilotte, Joseph R, Santiago, André da S, Langendorf, Christopher G, Oakhill, Jonathan S, Eduful, Benjamin J, Couñago, Rafael M, Wells, Carrow I, Zuercher, William J, Willson, Timothy M, Drewry, David H

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Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase von Asquith, Christopher R. M., Laitinen, Tuomo, Bennett, James M., Godoi, Paulo H., East, Michael P., Tizzard, Graham J., Graves, Lee M., Johnson, Gary L., Dornsife, Ronna E., Wells, Carrow I., Elkins, Jonathan M., Willson, Timothy M., Zuercher, William J.

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Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity von Asressu, Kesatebrhan Haile, Smith, Jeffery L, Dickmander, Rebekah J, Moorman, Nathaniel J, Wellnitz, James, Popov, Konstantin I, Axtman, Alison D, Willson, Timothy M

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK) von Asquith, Christopher R M, Bennett, James M, Su, Lianyong, Laitinen, Tuomo, Elkins, Jonathan M, Pickett, Julie E, Wells, Carrow I, Li, Zengbiao, Willson, Timothy M, Zuercher, William J

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The PPARs:  From Orphan Receptors to Drug Discovery von Willson, Timothy M, Brown, Peter J, Sternbach, Daniel D, Henke, Brad R

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Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia von Zhang, Yanqiao, Yin, Liya, Anderson, Jody, Ma, Huiyan, Gonzalez, Frank J., Willson, Timothy M., Edwards, Peter A.

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Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor von Kast, Heidi R., Goodwin, Bryan, Tarr, Paul T., Jones, Stacey A., Anisfeld, Andrew M., Stoltz, Catherine M., Tontonoz, Peter, Kliewer, Steve, Willson, Timothy M., Edwards, Peter A.

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1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors von Asquith, Christopher R M, Godoi, Paulo H, Couñago, Rafael M, Laitinen, Tuomo, Scott, John W, Langendorf, Christopher G, Oakhill, Jonathan S, Drewry, David H, Zuercher, William J, Koutentis, Panayiotis A, Willson, Timothy M, Kalogirou, Andreas S

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Synthetic LXR Ligand Inhibits the Development of Atherosclerosis in Mice von Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., Chen, Mingyi, Noh, Grace, Goodman, Joanne, Hagger, Graham N., Tran, Jonathan, Tippin, Tim K., Wang, Xuping, Lusis, Aldons J., Hsueh, Willa A., Law, Ronald E., Collins, Jon L., Willson, Timothy M., Tontonoz, Peter

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Structural Basis for an Unexpected Mode of SERM-Mediated ER Antagonism von Wu, Ya-Ling, Yang, Xiaojing, Ren, Zhong, McDonnell, Donald P., Norris, John D., Willson, Timothy M., Greene, Geoffrey L.

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