Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy von Keshari, Sunita, Shavkunov, Alexander S., Miao, Qi, Saha, Akata, Minowa, Tomoyuki, Molgora, Martina, Williams, Charmelle D., Chaib, Mehdi, Highsmith, Anna M., Pineda, Josué E., Alekseev, Sayan, Alspach, Elise, Hu, Kenneth H., Colonna, Marco, Pauken, Kristen E., Chen, Ken, Gubin, Matthew M.

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LP-118 is a novel B-cell lymphoma 2 / extra-large inhibitor that demonstrates efficacy in models of venetoclax-resistant chronic lymphocytic leukemia von Ravikrishnan, Janani, Diaz-Rohena, Daisy Y, Muhowski, Elizabeth, Mo, Xiaokui, Lai, Tzung-Huei, Misra, Shrilekha, Williams, Charmelle D, Sanchez, John, Mitchell, Andrew, Satpati, Suresh, Perry, Elizabeth, Kaufman, Tierney, Liu, Chaomei, Lozanski, Arletta, Lozanski, Gerard, Rogers, KerryA, Kittai, Adam S, Bhat, Seema A, Collins, Mary C, Davids, Matthew S, Jain, Nitin, Wierda, William G, Lapalombella, Rosa, Byrd, John C, Tan, Fenlai, Chen, Yi, Chen, Yu, Shen, Yue, Anthony, Stephen P, Woyach, Jennifer A, Sampath, Deepa

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BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy von Salmon, Avery J, Shavkunov, Alexander S, Miao, Qi, Jarjour, Nicholas N, Keshari, Sunita, Esaulova, Ekaterina, Williams, Charmelle D, Ward, Jeffrey P, Highsmith, Anna M, Pineda, Josué E, Taneja, Reshma, Chen, Ken, Edelson, Brian T, Gubin, Matthew M

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Defining the cooperation between T cell responses to MHC-I and MHC-II melanoma neoantigens towards developing effective personalized cancer immunotherapies von Williams, Charmelle, Shavkunov, Alexander, Keshari, Sunita, Salmon, Avery, Highsmith, Anna, Pineda, Josue, Gubin, Matthew

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Enriched Signalling Pathways in Venetoclax-Relapsed Chronic Lymphocytic Leukemia (CLL) Cells and Targeting Using a Protac-Based Bcl-2/Bcl-Xl Degrader von Diaz Rohena, Daisy, Peris Cuesta, Arnau, Slawin, Bailey, Ravikrishnan, Janani, Liu, Chaomei, Williams, Charmelle, Hu, Wanyi, Zhang, Peiyi, Thompson, Philip, Wierda, William G., Jain, Nitin, Shukla, Sachet, Zheng, Guangrong, Zhou, Daohong, Woyach, Jennifer A., Sampath, Deepa

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Abstract 1387: High-dimensional analysis of T cell responses to mutant neoantigens and nonmutant antigens in mouse models of melanoma von Keshari, Sunita, Williams, Charmelle D., Sanchez, Elizabeth D., Shavkunov, Alexander S., Gubin, Matthew M.

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Abstract 1365: BHLHE40 orchestrates remodeling of the intratumoral immune cell populations in response to immune checkpoint therapy von Shavkunov, Alexander S., Salmon, Avery J., Miao, Qi, Keshari, Sunita, Williams, Charmelle D., Pineda, Josué E., Chen, Ken, Edelson, Brian T., Gubin, Matthew M.

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