Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer von Lee, Suk Hyung, Hu, Wenhuo, Matulay, Justin T., Silva, Mark V., Owczarek, Tomasz B., Kim, Kwanghee, Chua, Chee Wai, Barlow, LaMont J., Kandoth, Cyriac, Williams, Alanna B., Bergren, Sarah K., Pietzak, Eugene J., Anderson, Christopher B., Benson, Mitchell C., Coleman, Jonathan A., Taylor, Barry S., Abate-Shen, Cory, McKiernan, James M., Al-Ahmadie, Hikmat, Solit, David B., Shen, Michael M.

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NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation von Papachristodoulou, Alexandros, Rodriguez-Calero, Antonio, Panja, Sukanya, Margolskee, Elizabeth, Virk, Renu K, Milner, Teresa A, Martina, Luis Pina, Kim, Jaime Y, Di Bernardo, Matteo, Williams, Alanna B, Maliza, Elvis A, Caputo, Joseph M, Haas, Christopher, Wang, Vinson, De Castro, Guarionex Joel, Wenske, Sven, Hibshoosh, Hanina, McKiernan, James M, Shen, Michael M, Rubin, Mark A, Mitrofanova, Antonina, Dutta, Aditya, Abate-Shen, Cory

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Hydroxychloroquine as Pre-exposure Prophylaxis for Coronavirus Disease 2019 (COVID-19) in Healthcare Workers: A Randomized Trial von Rajasingham, Radha, Bangdiwala, Ananta S, Nicol, Melanie R, Skipper, Caleb P, Pastick, Katelyn A, Axelrod, Margaret L, Pullen, Matthew F, Nascene, Alanna A, Williams, Darlisha A, Engen, Nicole W, Okafor, Elizabeth C, Rini, Brian I, Mayer, Ingrid A, McDonald, Emily G, Lee, Todd C, Li, Peter, MacKenzie, Lauren J, Balko, Justin M, Dunlop, Stephen J, Hullsiek, Katherine H, Boulware, David R, Lofgren, Sarah M

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders von Võsa, Urmo, Stathopoulou, Maria G., de Vries, Paul S., Tanaka, Toshiko, Wu, Ying, Karlsson, Robert, Pool, René, Kemp, John P., Verweij, Niek, Smith, Albert V., Huq, Mahmudul, Deelen, Joris, Alizadeh, Behrooz Z., van der Harst, Pim, Navis, Gerjan, Snieder, Harold, Chasman, Daniel I., Meigs, James, Ligthart, Symen, Bis, Josh, Gross, Myron, Koenig, Wolfgang, Uher, Rudolf, Ward-Caviness, Cavin, Boerwinkle, Eric, Stacey, David, Eriksson, Johan, Lahti, Jari, Schraut, Katharina E., Suktitipat, Bhoom, Nutile, Teresa, Schork, Nicholas, Thiering, Elisabeth, Mahajan, Anubha, Aslibekyan, Stella, Yengo, Loïc, Rajan, Kumar B., Timpson, Nicholas, Huang, Hongyan, Uh, Hae-Won, Yanek, Lisa R., Verbanck, Marie, Magnusson, Patrik K.E., Ballantyne, Christie M., Montgomery, Grant W., Rueedi, Rico, Steri, Maristella, Stott, David J., Felix, Stephan B., Kraft, Peter, Seppälä, Ilkka, Williams, Stephen R., Moed, Matthijs, Langenberg, Claudia, Räikkönen, Katri, Sale, Michele M., Chen, Yii-Der I., James, Alan L., Soranzo, Nicole, Berenson, Gerald S., Liewald, David, Beilby, John, Ryan, Kathleen A., Balkau, Beverly, Paternoster, Lavinia, Kähönen, Mika, Sattar, Naveed, van Heemst, Diana, Gambaro, Giovanni, Ferrucci, Luigi, Karlsson, Magnus, Lind, Lars, Mori, Trevor A., Buckley, Brendan M., de Craen, Anton J.M., Scott, Rodney J., Strachan, David P., Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Hamsten, Anders, Gudnason, Vilmundur, Qi, Lu, März, Winfried, Penninx, Brenda W.J.H., Worrall, Bradford B., Gibson, Greg, Oldehinkel, Albertine J., Murray, Sarah S., Pramstaller, Peter P., Deary, Ian J., Desch, Karl C., Hayward, Caroline, Arnett, Donna K., Jess, Tine, Psaty, Bruce M., Tracy, Russell P., Nolte, Ilja M., Visvikis-Siest, Sophie, Franke, Lude, Franco, Oscar H.

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A Model for Genome-First Care: Returning Secondary Genomic Findings to Participants and Their Healthcare Providers in a Large Research Cohort von Schwartz, Marci L.B., McCormick, Cara Zayac, Lazzeri, Amanda L., Lindbuchler, D’Andra M., Hallquist, Miranda L.G., Manickam, Kandamurugu, Buchanan, Adam H., Rahm, Alanna Kulchak, Giovanni, Monica A., Frisbie, Lauren, Flansburg, Carroll N., Davis, F. Daniel, Sturm, Amy C., Nicastro, Christine, Lebo, Matthew S., Mason-Suares, Heather, Mahanta, Lisa Marie, Carey, David J., Williams, Janet L., Williams, Marc S., Ledbetter, David H., Faucett, W. Andrew, Murray, Michael F.

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Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways von Kasher, Melody, Williams, Frances M K, Freidin, Maxim B, Malkin, Ida, Cherny, Stacey S, Livshits, Gregory

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Establishing a National Cardiovascular Disease Surveillance System in the United States Using Electronic Health Record Data: Key Strengths and Limitations von Williams, Brent A, Voyce, Stephen, Sidney, Stephen, Roger, Véronique L, Plante, Timothy B, Larson, Sharon, LaMonte, Michael J, Labarthe, Darwin R, DeBarmore, Bailey M, Chang, Alexander R, Chamberlain, Alanna M, Benziger, Catherine P

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Clinical outcomes of a genomic screening program for actionable genetic conditions von Buchanan, Adam H., Lester Kirchner, H., Schwartz, Marci L. B., Kelly, Melissa A., Schmidlen, Tara, Jones, Laney K., Hallquist, Miranda L. G., Rocha, Heather, Betts, Megan, Schwiter, Rachel, Butry, Loren, Lazzeri, Amanda L., Frisbie, Lauren R., Rahm, Alanna Kulchak, Hao, Jing, Willard, Huntington F., Martin, Christa L., Ledbetter, David H., Williams, Marc S., Sturm, Amy C.

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Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study von Paulsen, Jane S, Dr Prof, Long, Jeffrey D, Prof, Ross, Christopher A, Prof, Harrington, Deborah L, Prof, Erwin, Cheryl J, JD, Williams, Janet K, Prof, Westervelt, Holly James, PhD, Johnson, Hans J, PhD, Aylward, Elizabeth H, PhD, Zhang, Ying, Prof, Bockholt, H Jeremy, BS, Barker, Roger A, Prof

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Meta-analysis of Correlated Traits via Summary Statistics from GWASs with an Application in Hypertension von Zhu, Xiaofeng, Feng, Tao, Tayo, Bamidele O., Liang, Jingjing, Young, J. Hunter, Franceschini, Nora, Smith, Jennifer A., Yanek, Lisa R., Sun, Yan V., Edwards, Todd L., Chen, Wei, Nalls, Mike, Fox, Ervin, Sale, Michele, Bottinger, Erwin, Rotimi, Charles, Liu, Yongmei, McKnight, Barbara, Liu, Kiang, Arnett, Donna K., Chakravati, Aravinda, Cooper, Richard S., Redline, Susan

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Patient selection for milk and egg ladders using a food ladder safety checklist von Chua, Gilbert T, Chan, Edmond S, Yeung, Joanne, Cameron, Scott B, Soller, Lianne, Williams, Brock A, Chomyn, Alanna, Vander Leek, Timothy K, Abrams, Elissa M, Mak, Raymond, Wong, Tiffany

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Positive impact of genetic counseling assistants on genetic counseling efficiency, patient volume, and cost in a cancer genetics clinic von Hallquist, Miranda L. G., Tricou, Eric P., Hallquist, Michael N., Savatt, Juliann M., Rocha, Heather, Evans, Alyson E., Deckard, Nicole, Hu, Yirui, Kirchner, H. Lester, Pervola, Josie, Rahm, Alanna Kulchak, Rashkin, Misha, Schmidlen, Tara J., Schwartz, Marci L. B., Williams, Janet L., Williams, Marc S., Buchanan, Adam H.

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A linear relationship between crystal size and fragment binding time observed crystallographically: implications for fragment library screening using acoustic droplet ejection von Cole, Krystal, Roessler, Christian G, Mulé, Elizabeth A, Benson-Xu, Emma J, Mullen, Jeffrey D, Le, Benjamin A, Tieman, Alanna M, Birone, Claire, Brown, Maria, Hernandez, Jesus, Neff, Sherry, Williams, Daniel, Allaire, Marc, Orville, Allen M, Sweet, Robert M, Soares, Alexei S

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Returning Results in the Genomic Era: Initial Experiences of the eMERGE Network von Wiesner, Georgia L, Kulchak Rahm, Alanna, Appelbaum, Paul, Aufox, Sharon, Bland, Sarah T, Blout, Carrie L, Christensen, Kurt D, Chung, Wendy K, Clayton, Ellen Wright, Green, Robert C, Harr, Margaret H, Henrikson, Nora, Hoell, Christin, Holm, Ingrid A, Jarvik, Gail P, Kullo, Iftikhar J, Lammers, Philip E, Larson, Eric B, Lindor, Noralane M, Marasa, Maddalena, F Myers, Melanie, Peterson, Josh F, Prows, Cynthia A, Ralston, James D, Milo Rasouly, Hila, Sharp, Richard R, Smith, Maureen E, Van Driest, Sara L, Williams, Janet L, Williams, Marc S, Wynn, Julia, Leppig, Kathleen A

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Association of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes von Watson, R. Scott, Beers, Sue R, Asaro, Lisa A, Burns, Cheryl, Koh, Min Jung, Perry, Mallory A, Angus, Derek C, Wypij, David, Curley, Martha A.Q

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Exome Sequencing-Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants von Manickam, Kandamurugu, Buchanan, Adam H, Schwartz, Marci L B, Hallquist, Miranda L G, Williams, Janet L, Rahm, Alanna Kulchak, Rocha, Heather, Savatt, Juliann M, Evans, Alyson E, Butry, Loren M, Lazzeri, Amanda L, Lindbuchler, D'Andra M, Flansburg, Carroll N, Leeming, Rosemary, Vogel, Victor G, Lebo, Matthew S, Mason-Suares, Heather M, Hoskinson, Derick C, Abul-Husn, Noura S, Dewey, Frederick E, Overton, John D, Reid, Jeffrey G, Baras, Aris, Willard, Huntington F, McCormick, Cara Z, Krishnamurthy, Sarath B, Hartzel, Dustin N, Kost, Korey A, Lavage, Daniel R, Sturm, Amy C, Frisbie, Lauren R, Person, T Nate, Metpally, Raghu P, Giovanni, Monica A, Lowry, Lacy E, Leader, Joseph B, Ritchie, Marylyn D, Carey, David J, Justice, Anne E, Kirchner, H Lester, Faucett, W Andrew, Williams, Marc S, Ledbetter, David H, Murray, Michael F

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Understanding the Return of Genomic Sequencing Results Process: Content Review of Participant Summary Letters in the eMERGE Research Network von Lynch, John A, Sharp, Richard R, Aufox, Sharon A, Bland, Sarah T, Blout, Carrie, Bowen, Deborah J, Buchanan, Adam H, Halverson, Colin, Harr, Margaret, Hebbring, Scott J, Henrikson, Nora, Hoell, Christin, Holm, Ingrid A, Jarvik, Gail, Kullo, Iftikhar J, Kochan, David C, Larson, Eric B, Lazzeri, Amanda, Leppig, Kathleen A, Madden, Jill, Marasa, Maddalena, Myers, Melanie F, Peterson, Josh, Prows, Cynthia A, Kulchak Rahm, Alanna, Ralston, James, Milo Rasouly, Hila, Scrol, Aaron, Smith, Maureen E, Sturm, Amy, Stuttgen, Kelsey, Wiesner, Georgia, Williams, Marc S, Wynn, Julia, Williams, Janet L

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Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits von Keaton, Jacob M., Kamali, Zoha, Xie, Tian, Vaez, Ahmad, Ani, Alireza, Hellwege, Jacklyn N., Yengo, Loic, Young, William J., Traylor, Matthew, Giri, Ayush, Zheng, Zhili, Zeng, Jian, Chasman, Daniel I., Morris, Andrew P., Caulfield, Mark J., Hwang, Shih-Jen, Kooner, Jaspal S., Conen, David, Attia, John R., Morrison, Alanna C., Loos, Ruth J. F., Hicks, Andrew A., Pramstaller, Peter P., Nelson, Christopher P., Melander, Olle, Riese, Harriette, Wilson, James F., Campbell, Harry, Rich, Stephen S., Psaty, Bruce M., Lu, Yingchang, Rotter, Jerome I., Guo, Xiuqing, Vollenweider, Peter, Langenberg, Claudia, Tuomilehto, Jaakko, Salomaa, Veikko, Girotto, Giorgia, Trompet, Stella, Jukema, J. Wouter, van der Harst, Pim, Ridker, Paul M., Vitart, Veronique, Goel, Anuj, Harris, Sarah E., Deary, Ian J., van der Most, Peter J., Oldehinkel, Albertine J., Campbell, Archie, Boehnke, Michael, Boutin, Thibaud, Mamasoula, Chrysovalanto, Knekt, Paul, Enroth, Stefan, Polašek, Ozren, Concas, Maria Pina, Catamo, Eulalia, Cocca, Massimiliano, Li-Gao, Ruifang, Hofer, Edith, Spedicati, Beatrice, Waldenberger, Melanie, Laan, Maris, Teumer, Alexander, Cook, James P., Ruggiero, Daniela, Kolcic, Ivana, Boerwinkle, Eric, Traglia, Michela, Lehtimäki, Terho, Raitakari, Olli T., Johnson, Andrew D., Newton-Cheh, Christopher, Dominiczak, Anna F., Sever, Peter J., Siscovick, David, Metspalu, Andres, Strawbridge, Rona J., Laakso, Markku, Hottenga, Jouke-Jan, Morris, Andrew D., Nolte, Ilja M., Milaneschi, Yuri, Marten, Jonathan, Wright, Alan, Zeggini, Eleftheria, Spector, Tim, Simonsick, Eleanor M., van Duijn, Cornelia M., Butterworth, Adam S., Danesh, John N., Khaw, Kay-Tee, Sun, Yan V., Wilson, Peter W. F., Cho, Kelly, Levy, Daniel, Edwards, Todd L., Munroe, Patricia B., Snieder, Harold, Warren, Helen R.

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Identification and Management of Ankyloglossia and Its Effect on Breastfeeding in Infants: Clinical Report von Thomas, Jennifer, Bunik, Maya, Holmes, Alison, Keels, Martha Ann, Poindexter, Brenda, Meyer, Anna, Gilliland, Alison

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Implementation of Virtual Fontan Heart Camps During a Pandemic von Tham, Edythe B, Harake, Danielle E, Lin, Lily Q, Du, Katie J, Harris, Lucy E, Williams, Elina, Ash, Alanna L, Escudero, Carolina A

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