mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity von Cheng, Shih-Chin, Quintin, Jessica, Cramer, Robert A., Shepardson, Kelly M., Saeed, Sadia, Kumar, Vinod, Giamarellos-Bourboulis, Evangelos J., Martens, Joost H. A., Rao, Nagesha Appukudige, Aghajanirefah, Ali, Manjeri, Ganesh R., Li, Yang, Ifrim, Daniela C., Arts, Rob J. W., van der Meer, Brian M. J. W., Deen, Peter M. T., Logie, Colin, O’Neill, Luke A., Willems, Peter, van de Veerdonk, Frank L., van der Meer, Jos W. M., Ng, Aylwin, Joosten, Leo A. B., Wijmenga, Cisca, Stunnenberg, Hendrik G., Xavier, Ramnik J., Netea, Mihai G.

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Hydrocortisone plus Fludrocortisone for Adults with Septic Shock von Annane, Djillali, Renault, Alain, Brun-Buisson, Christian, Megarbane, Bruno, Quenot, Jean-Pierre, Siami, Shidasp, Cariou, Alain, Forceville, Xavier, Schwebel, Carole, Martin, Claude, Timsit, Jean-François, Misset, Benoît, Ali Benali, Mohamed, Colin, Gwenhael, Souweine, Bertrand, Asehnoune, Karim, Mercier, Emmanuelle, Chimot, Loïc, Charpentier, Claire, François, Bruno, Boulain, Thierry, Petitpas, Franck, Constantin, Jean-Michel, Dhonneur, Gilles, Baudin, François, Combes, Alain, Bohé, Julien, Loriferne, Jean-François, Amathieu, Roland, Cook, Fabrice, Slama, Michel, Leroy, Olivier, Capellier, Gilles, Dargent, Auguste, Hissem, Tarik, Maxime, Virginie, Bellissant, Eric

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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans von Scott, Robert A, Scott, Laura J, Mägi, Reedik, Marullo, Letizia, Gaulton, Kyle J, Kaakinen, Marika, Pervjakova, Natalia, Pers, Tune H, Johnson, Andrew D, Eicher, John D, Jackson, Anne U, Ferreira, Teresa, Lee, Yeji, Ma, Clement, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Van Zuydam, Natalie R, Mahajan, Anubha, Chen, Han, Almgren, Peter, Voight, Ben F, Grallert, Harald, Müller-Nurasyid, Martina, Ried, Janina S, Rayner, Nigel W, Robertson, Neil, Karssen, Lennart C, van Leeuwen, Elisabeth M, Willems, Sara M, Fuchsberger, Christian, Kwan, Phoenix, Teslovich, Tanya M, Chanda, Pritam, Li, Man, Lu, Yingchang, Dina, Christian, Thuillier, Dorothee, Yengo, Loic, Jiang, Longda, Sparso, Thomas, Kestler, Hans A, Chheda, Himanshu, Eisele, Lewin, Gustafsson, Stefan, Frånberg, Mattias, Strawbridge, Rona J, Benediktsson, Rafn, Hreidarsson, Astradur B, Kong, Augustine, Sigurðsson, Gunnar, Kerrison, Nicola D, Luan, Jian'an, Liang, Liming, Meitinger, Thomas, Roden, Michael, Thorand, Barbara, Esko, Tõnu, Mihailov, Evelin, Fox, Caroline, Liu, Ching-Ti, Rybin, Denis, Isomaa, Bo, Lyssenko, Valeriya, Tuomi, Tiinamaija, Couper, David J, Pankow, James S, Grarup, Niels, Have, Christian T, Jørgensen, Marit E, Jørgensen, Torben, Linneberg, Allan, Cornelis, Marilyn C, van Dam, Rob M, Hunter, David J, Kraft, Peter, Sun, Qi, Edkins, Sarah, Owen, Katharine R, Perry, John R B, Wood, Andrew R, Zeggini, Eleftheria, Tajes-Fernandes, Juan, Abecasis, Goncalo R, Bonnycastle, Lori L, Chines, Peter S, Stringham, Heather M, Koistinen, Heikki A, Kinnunen, Leena, Sennblad, Bengt, Mühleisen, Thomas W, Nöthen, Markus M, Pechlivanis, Sonali, Baldassarre, Damiano, Gertow, Karl, Humphries, Steve E, Tremoli, Elena, Klopp, Norman, Meyer, Julia, Steinbach, Gerald

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Colorectal liver metastases: surgery versus thermal ablation (COLLISION) - a phase III single-blind prospective randomized controlled trial von Puijk, Robbert S, Ruarus, Alette H, Vroomen, Laurien G P H, van Tilborg, Aukje A J M, Scheffer, Hester J, Nielsen, Karin, de Jong, Marcus C, de Vries, Jan J J, Zonderhuis, Babs M, Eker, Hasan H, Kazemier, Geert, Verheul, Henk, van der Meijs, Bram B, van Dam, Laura, Sorgedrager, Natasha, Coupé, Veerle M H, van den Tol, Petrousjka M P, Meijerink, Martijn R

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Rare and low-frequency coding variants alter human adult height von Wood, Andrew R., Kjaer, Troels R., Lu, Yingchang, Thorleifsson, Gudmar, Turcot, Valérie, Young, Kristin L., Rivas, Manuel A., Abecasis, Goncalo, Aben, Katja K., Allin, Kristine H., Blüher, Matthias, Bots, Michiel L., Brilliant, Murray H., Carey, David J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chu, Audrey Y., Collins, Francis S., Cook, James P., de Groot, Mark C. H., de Mutsert, Renée, Ebeling, Tapani, Evangelou, Evangelos, Feng, Shuang, Ford, Ian, Fornage, Myriam, Gandin, Ilaria, Gordon, Scott D., Gustafsson, Stefan, Hattersley, Andrew T., Heid, Iris M., Helgeland, Øyvind, Hewitt, Alex W., Hovingh, G. Kees, Hoyng, Carel B., Huang, Paul L., Hveem, Kristian, Ikram, M. Arfan, Jansson, Jan-Håkan, Jarvik, Gail P., Jiang, Xuejuan, Jukema, J. Wouter, Kitajima, Hidetoshi, Kluivers, Kirsten B., Kontto, Jukka, Kooner, Jaspal S., Kriebel, Jennifer, Kuusisto, Johanna, Langenberg, Claudia, Lee, I-Te, Li, Huaixing, Lin, Honghuang, Lophatananon, Artitaya, Lyytikäinen, Leo-Pekka, Madden, Pamela A. F., Männistö, Satu, Mazul, Angela L., Metspalu, Andres, Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew P., Müller-Nurasyid, Martina, Nalls, Mike A., Nielsen, Sune F., Njølstad, Pål R., Palmer, Colin N. A., Pasterkamp, Gerard, Pedersen, Oluf, Perola, Markus, Perry, James A., Person, Thomas N., Salomaa, Veikko, Samani, Nilesh J., Sandow, Kevin, Schmidt, Marjanka K., Segura-Lepe, Marcelo P., Sim, Xueling, Small, Kerrin S., Southam, Lorraine, Steinthorsdottir, Valgerdur, Stumvoll, Michael, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Thompson, Deborah J., Tyrer, Jonathan P., Uitterlinden, André G., van Schoor, Natasja M., Vozzi, Diego, Wang, Shuai, Wang, Yiqin, Wilson, James G., Young, Robin, Willer, Cristen J., Liu, Dajiang J., North, Kari E., Kutalik, Zoltán, Loos, Ruth J. F., Deloukas, Panos

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Saturable elimination of piperacillin in critically ill patients: implications for continuous infusion von Dhaese, S.A.M., Colin, P., Willems, H., Heffernan, A., Gadeyne, B., Van Vooren, S., Depuydt, P., Hoste, E., Stove, V., Verstraete, A.G., Lipman, J., Roberts, J.A., De Waele, J.J.

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology von Southam, Lorraine, Yin, Xianyong, Melloni, Giorgio E. M., Rayner, Nigel W., Bocher, Ozvan, Namba, Shinichi, Lee, Simon S. K., Petty, Lauren E., Schroeder, Philip, Kals, Mart, Zhang, Weihua, Graff, Mariaelisa, Lamri, Amel, Parra, Esteban J., Bielak, Lawrence F., Hai, Yang, Sofer, Tamar, Nousome, Darryl, Sun, Meng, Noordam, Raymond, Lim, Victor J. Y., Yanek, Lisa R., An, Ping, Tan, Jingyi, Canouil, Mickaël, Chee, Miao-Li, Chen, Shyh-Huei, Chen, Yuan-Tsong, Dimitrov, Latchezar, Doumatey, Ayo P., Du, Shufa, Eckardt, Kai-Uwe, Gerstein, Hertzel C., Han, Sohee, Herder, Christian, Howard, Annie-Green, Hsueh, Willa, Ichihara, Sahoko, Ikram, Mohammad Arfan, Jang, Hye-Mi, Jonas, Jost B., Kandeel, Fouad R., Kaur, Varinderpal, Lange, Leslie A., Lee, Myung-Shik, Leong, Aaron, Liu, Ching-Ti, Louie, Tin, Luo, Xi, Maeda, Shiro, Mansuri, Sohail Rafik, Nalls, Michael A., Nayak, Uma, Okada, Yukinori, Patil, Snehal, Prasad, Gauri, Roden, Michael, Rohde, Rebecca, Sandow, Kevin, Sankareswaran, Alagu, So, Wing Yee, Stilp, Adrienne M., Taylor, Kent D., Thorand, Barbara, Valladares-Salgado, Adan, Wheeler, Eleanor, Raffel, Leslie J., Igase, Michiya, Province, Michael A., Rotimi, Charles N., Peyser, Patricia A., Pankow, James S., Wilson, James G., Sheu, Wayne H. H., Mook-Kanamori, Dennis O., Collins, Francis S., Paré, Guillaume, Shu, Xiao-Ou, Dupuis, Josee, Kato, Norihiro, Laakso, Markku, Wareham, Nicholas J., Kim, Bong-Jo, Stefansson, Kari, Goodarzi, Mark O., Mohlke, Karen L., Florez, Jose C., Zöllner, Sebastian, Mägi, Reedik, van Heel, David A., Finer, Sarah, Ng, Maggie C. Y., Sim, Xueling, Below, Jennifer E., Chang, Kyong-Mi, Meigs, James B., Mahajan, Anubha, Vujkovic, Marijana, Voight, Benjamin F., Morris, Andrew P.

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Femoral vs Jugular Venous Catheterization and Risk of Nosocomial Events in Adults Requiring Acute Renal Replacement Therapy: A Randomized Controlled Trial von Parienti, Jean-Jacques, Thirion, Marina, Mégarbane, Bruno, Souweine, Bertrand, Ouchikhe, Abdelali, Polito, Andrea, Forel, Jean-Marie, Marqué, Sophie, Misset, Benoît, Airapetian, Norair, Daurel, Claire, Mira, Jean-Paul, Ramakers, Michel, du Cheyron, Damien, Le Coutour, Xavier, Daubin, Cédric, Charbonneau, Pierre, for Members of the Cathedia Study Group

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Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes von YAGHOOTKAR, Hanieh, LAMINA, Claudia, YING WU, CHEUNG, Chloe Y. Y, PANKOW, James S, JACKSON, Anne U, GUSTAFSSON, Stefan, JING HUA ZHAO, BALLANTYNE, Christie M, WEIJIA XIE, BERGMAN, Richard N, BOEHNKE, Michael, SCOTT, Robert A, EL BOUAZZAOUI, Fatiha, COLLINS, Francis S, DUNN, Sandra H, DUPUIS, Josee, FOROUHI, Nita G, GILLSON, Christopher, HATTERSLEY, Andrew T, JAEYOUNG HONG, KÄHÖNEN, Mika, KUUSISTO, Johanna, DASTANI, Zari, KEDENKO, Lyudmyla, KRONENBERG, Florian, DORIA, Alessandro, ASSIMES, Themistocles L, FERRANNINI, Ele, HANSEN, Torben, KE HAO, HÄRING, Hans, KNOWLES, Joshua W, LINDGREN, Cecilia M, HIVERT, Marie-France, NOLAN, John J, PAANANEN, Jussi, PEDERSEN, Oluf, QUERTERMOUS, Thomas, SMITH, Ulf, LEHTIMÄKI, Terho, LIU, Ching-Ti, LOOS, Ruth J. F, MCCARTHY, Mark I, MORRIS, Andrew D, WARREN, Liling L, VASAN, Ramachandran S, SPECTOR, Tim D, TESLOVICH, Tanya M, TUOMILEHTO, Jaakko, VAN DIJK, Ko Willems, VIIKARI, Jorma S, NA ZHU, STANCAKOVA, Alena, BUXBAUM, Sarah G, LYYTIKÄINEN, Leo-Pekka, HENNEMAN, Peter

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Common variants near MC4R are associated with fat mass, weight and risk of obesity von Day, Ian, Dermitzakis, Emmanouil T, Randall, Joshua C, Weedon, Michael N, Hinney, Anke, Evans, David M, Qi, Lu, Bennett, Amanda J, Munroe, Patricia B, Herrera, Blanca, Johnson, Toby, Elliott, Katherine S, Song, Kijoung, Zeggini, Eleftheria, Cauchi, Stéphane, Teichmann, Sarah A, Lindgren, Cecilia M, Brown, Morris, Sims, Matthew A, Karpe, Fredrik, O'Rahilly, Stephen, Hattersley, Andrew T, Scherag, André, Samani, Nilesh J, Keniry, Andrew, Li, Shengxu, Beckmann, Jacques S, Cooper, Cyrus, Caulfield, Mark J, Owen, Katharine R, Luben, Robert N, McGinnis, Ralph, Ghori, Jilur, Ness, Andrew R, Bochud, Murielle, Jarvelin, Marjo-Riitta, Hebebrand, Johannes, Ong, Ken K, Freathy, Rachel M, McArdle, Wendy L, Potter, Simon, Wareham, Nicholas J, Ganz Vogel, Carla I, Mooser, Vincent, Barroso, Inês, Deloukas, Panos, Waterworth, Dawn M, Bergmann, Sven, Elliott, Paul, Gwilliam, Rhian, Tobias, Jonathan H, Jolley, Jennifer D M, Morris, Andrew D, Loos, Ruth J F, Yuan, Xin, Smith, George Davey, Palmer, Colin N A, Groves, Christopher J, Dina, Christian, Syddall, Holly E, Waeber, Gerard, Zhao, Jing Hua, Sandhu, Manjinder S, Doney, Alex S F, Hunt, Sarah E, Pouta, Anneli, Speliotes, Elizabeth K, Connell, John M, Timpson, Nicholas J, Wallace, Chris, Attwood, Antony P, Hall, Alistair S, Khaw, Kay-Tee, Meyre, David, Vollenweider, Peter, Bingham, Sheila A, Berndt, Sonja I, Hadley, David, Rayner, Nigel W, Frayling, Timothy M, Sadaf Farooqi, I, Hirschhorn, Joel N, Strachan, David P, Inouye, Michael, Papadakis, Konstantinos, Ring, Susan M, Wraight, Vicki L, Willer, Cristen J, Marchini, Jonathan, Uda, Manuela, Nica, Alexandra C, Mangino, Massimo, Soranzo, Nicole, McCarthy, Mark I, De, Subhajyoti, Neville, Matthew J, Prokopenko, Inga, Wheeler, Eleanor, Heid, Iris M, Froguel, Philippe

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Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M... von Cheng, Tsing, Hitomi, Kiyotaka, van Vlijmen-Willems, Ivonne M J J, de Jongh, Gys J, Yamamoto, Kanae, Nishi, Koji, Watts, Colin, Reinheckel, Thomas, Schalkwijk, Joost, Zeeuwen, Patrick L J M

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Cost of exome analysis in patients with intellectual disability: a micro-costing study in a French setting von Soilly, A L, Robert-Viard, C, Besse, C, Bruel, A L, Gerard, B, Boland, A, Piton, A, Duffourd, Y, Muller, J, Poë, C, Jouan, T, El Doueiri, S, Faivre, L, Bacq-Daian, D, Isidor, B, Genevieve, D, Odent, S, Philip, N, Doco-Fenzy, M, Lacombe, D, Asensio, M L, Deleuze, J F, Binquet, C, Thauvin-Robinet, C, Lejeune, C

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Clinical, neuroradiological and genetic findings in pontocerebellar hypoplasia von NAMAVAR, Yasmin, BARTH, Peter G, BASEL-VANAGAITE, Lina, EGGENS, Veerle R. C, KRÄGELOH-MANN, Ingeborg, DE MEIRLEIR, Linda, KING, Mary, GRAHAM JR, John M, VON MOERS, Arpad, KNOERS, Nine, SZTRIHA, Laszlo, KORINTHENBERG, Rudolf, KASHER, Paul R, DOBYNS, William B, BAAS, Frank, TIEN POLL-THE, Bwee, VAN RUISSEN, Fred, BROCKMANN, Knut, BERNERT, Günther, WRITZL, Karin, VENTURA, Karen, CHENG, Edith Y, FERRIERO, Donna M

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Human Cytomegalovirus Infection of Epithelial Cells Increases SARS-CoV-2 Superinfection by Upregulating the ACE2 Receptor von Perera, Marianne R, Greenwood, Edward J D, Crozier, Thomas W M, Elder, Elizabeth G, Schmitt, Janika, Crump, Colin M, Lehner, Paul J, Wills, Mark R, Sinclair, John H

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Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension von Hadinnapola, Charaka, Bleda, Marta, Haimel, Matthias, Screaton, Nicholas, Swift, Andrew, Dorfmüller, Peter, Preston, Stephen D, Southwood, Mark, Hernandez-Sanchez, Jules, Martin, Jennifer, Treacy, Carmen, Yates, Katherine, Bogaard, Harm, Church, Colin, Coghlan, Gerry, Condliffe, Robin, Corris, Paul A, Gibbs, Simon, Girerd, Barbara, Holden, Simon, Humbert, Marc, Kiely, David G, Lawrie, Allan, Machado, Rajiv, MacKenzie Ross, Robert, Moledina, Shahin, Montani, David, Newnham, Michael, Peacock, Andrew, Pepke-Zaba, Joanna, Rayner-Matthews, Paula, Shamardina, Olga, Soubrier, Florent, Southgate, Laura, Suntharalingam, Jay, Toshner, Mark, Trembath, Richard, Vonk Noordegraaf, Anton, Wilkins, Martin R, Wort, Stephen J, Wharton, John, Gräf, Stefan, Morrell, Nicholas W

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Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function von Wen, Xiao-Yan, Tarailo-Graovac, Maja, Brand-Arzamendi, Koroboshka, Willems, Anke, Rakic, Bojana, Huijben, Karin, Da Silva, Afitz, Pan, Xuefang, El-Rass, Suzan, Ng, Robin, Selby, Katheryn, Philip, Anju Mary, Yun, Junghwa, Ye, X Cynthia, Ross, Colin J, Lehman, Anna M, Zijlstra, Fokje, Abu Bakar, N, Drögemöller, Britt, Moreland, Jacqueline, Wasserman, Wyeth W, Vallance, Hilary, van Scherpenzeel, Monique, Karbassi, Farhad, Hoskings, Martin, Engelke, Udo, de Brouwer, Arjan, Wevers, Ron A, Pshezhetsky, Alexey V, van Karnebeek, Clara Dm, Lefeber, Dirk J

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Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance von Pitsiladis, Yannis P, Tanaka, Masashi, Eynon, Nir, Bouchard, Claude, North, Kathryn N, Williams, Alun G, Collins, Malcolm, Moran, Colin N, Britton, Steven L, Fuku, Noriyuki, Ashley, Euan A, Klissouras, Vassilis, Lucia, Alejandro, Ahmetov, Ildus I, de Geus, Eco, Alsayrafi, Mohammed

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Vascular Access Sites for Acute Renal Replacement in Intensive Care Units von Dugué, Audrey E, Levesque, Stéphanie P, Fischer, Marc-Olivier, Souweine, Bertrand, Mira, Jean-Paul, Megarbane, Bruno, Daubin, Cédric, du Cheyron, Damien, Parienti, Jean-Jacques

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Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study von Wösten-van Asperen, Roelie M., la Roi-Teeuw, Hannah M., van Amstel, Rombout BE, Bos, Lieuwe DJ, Tissing, Wim JE, Jordan, Iolanda, Dohna-Schwake, Christian, Bottari, Gabriella, Pappachan, John, Crazzolara, Roman, Comoretto, Rosanna I., Mizia-Malarz, Agniezka, Moscatelli, Andrea, Sánchez-Martín, María, Willems, Jef, Rogerson, Colin M., Bennett, Tellen D., Luo, Yuan, Atreya, Mihir R., Faustino, E.Vincent S., Geva, Alon, Weiss, Scott L., Schlapbach, Luregn J., Sanchez-Pinto, L Nelson, Caballero, Marina, Margarit, Adriana, Campos, Roi, Möller, Paula, Serpe, Carmela, Amigoni, Angela, Damps, Maria, Montaguti, Alessia, Tardini, Giacomo, Bubeck-Wardenburg, Juliane, Farris, Reid Farris, Hall, Mark, Chong, Grace, Shah, Sareen, Khemani, Robinder, Stroup, Emily

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A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance von Haring, Martijn P D, Elfrink, Arthur K E, Oudmaijer, Christiaan A J, Andel, Paul C M, Furumaya, Alicia, de Jong, Nenke, Willems, Colin J J M, Huits, Thijs, Sijmons, Julie M L, Belt, Eric J T, Bosscha, Koop, Consten, Esther C J, Coolsen, Mariëlle M E, van Duijvendijk, Peter, Erdmann, Joris I, Gobardhan, Paul, de Haas, Robbert J, van Heek, Tjarda, Lam, Hwai-Ding, Leclercq, Wouter K G, Liem, Mike S L, Marsman, Hendrik A, Patijn, Gijs A, Terkivatan, Türkan, Zonderhuis, Babs M, Molenaar, Izaak Quintus, Te Riele, Wouter W, Hagendoorn, Jeroen, Schaapherder, Alexander F M, IJzermans, Jan N M, Buis, Carlijn I, Klaase, Joost M, de Jong, Koert P, de Meijer, Vincent E

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