Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance von Salami, Jemilat, Alabi, Shanique, Willard, Ryan R., Vitale, Nick J., Wang, Jing, Dong, Hanqing, Jin, Meizhong, McDonnell, Donald P., Crew, Andrew P., Neklesa, Taavi K., Crews, Craig M.

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Catalytic in vivo protein knockdown by small-molecule PROTACs von Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M

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Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes von Friborg, Jacques, Ross-Macdonald, Petra, Cao, Jian, Willard, Ryan, Lin, Baiqing, Eggers, Betsy, McPhee, Fiona

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Heterocyclic Compounds That Inhibit Rev-RRE Function and Human Immunodeficiency Virus Type 1 Replication von SHUCK-LEE, Deidra, FEI FEI CHEN, WILLARD, Ryan, RAMAN, Sharmila, PTAK, Roger, HAMMARSKJOLD, Marie-Louise, REKOSH, David

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Microsoft SharePoint Premium in the Real World: Bringing Practical Cloud AI to Content Management von Sanford, Jacob J, Windischman, Woodrow W, Willard, Dustin, Dennis, Ryan, McNulty, Chris

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Predicting Men's Acceptance of Sexual Violence Myths Through Conformity to Masculine Norms, Sexism, and "Locker Room Talk" von Cole, Brian P., Brennan, Margaret, Tyler, Emily, Willard, Ryan

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Characterization of two subpopulations of the PICM-19 porcine liver stem cell line for use in cell-based extracorporeal liver assistance devices von TALBOT, Neil C, CAPERNA, Thomas J, WILLARD, Ryan R, MEEKIN, John H, GARRETT, Wesley M

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Cytochrome P450 expression profile of the PICM-19H pig liver cell line: potential application to rapid liver toxicity assays von Willard, Ryan R, Shappell, Nancy W, Meekin, John H, Talbot, Neil C, Caperna, Thomas J

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Psychology of Men and Masculinities' Focus on Positive Aspects of Men's Functioning: A Content Analysis and Call to Action von Cole, Brian P., Moffitt-Carney, Kelsey, Patterson, Tristan P., Willard, Ryan

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Abstract 43: Discovery of ARV-110, a first in class androgen receptor degrading PROTAC for the treatment of men with metastatic castration resistant prostate cancer von Snyder, Lawrence B., Neklesa, Taavi K., Chen, Xin, Dong, Hanqing, Ferraro, Caterina, Gordon, Deborah A., Macaluso, Jennifer, Pizzano, Jennifer, Wang, Jing, Willard, Ryan R., Vitale, Nicholas, Peck, Ron, Moore, Marcia Dougan, Crews, Craig M., Houston, John, Crew, Andrew P., Taylor, Ian

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Abstract 44: The discovery of ARV-471, an orally bioavailable estrogen receptor degrading PROTAC for the treatment of patients with breast cancer von Snyder, Lawrence B., Flanagan, John J., Qian, Yimin, Gough, Sheryl M., Andreoli, Monica, Bookbinder, Mark, Cadelina, Gregory, Bradley, John, Rousseau, Emma, Chandler, Julian, Willard, Ryan, Pizzano, Jennifer, Crews, Craig M., Crew, Andrew P., Houston, John, Moore, Marcia Dougan, Peck, Ron, Taylor, Ian

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ARV-110: An oral androgen receptor PROTAC degrader for prostate cancer von Neklesa, Taavi, Snyder, Lawrence B, Willard, Ryan R, Vitale, Nicholas, Pizzano, Jennifer, Gordon, Deborah A, Bookbinder, Mark, Macaluso, Jennifer, Dong, Hanqing, Ferraro, Caterina, Wang, Gan, Wang, Jing, Crews, Craig M, Houston, John, Crew, Andrew P, Taylor, Ian

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Abstract 5076: IHC and flow cytometry quantifies BRD4 levels in surrogate tissues after ex-vivo and in-vivo dosing with a BRD4 degrading PROTAC von Gough, Sheryl M., Raina, Kanak, Gordon, Debbie, Willard, Ryan, Altieri, Martha, Shen, Angela, Qian, Yimin, Neklesa, Taavi, Coleman, Kevin, Taylor, Ian

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Abstract 5236: ARV-110: An androgen receptor PROTAC degrader for prostate cancer von Neklesa, Taavi, Snyder, Lawrence B., Willard, Ryan R., Vitale, Nicholas, Raina, Kanak, Pizzano, Jennifer, Gordon, Deborah, Bookbinder, Mark, Macaluso, Jennifer, Dong, Hanqing, Liu, Zheng, Ferraro, Caterina, Wang, Gan, Wang, Jing, Crews, Craig M., Houston, John, Crew, Andrew P., Taylor, Ian

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An oral androgen receptor PROTAC degrader for prostate cancer von Neklesa, Taavi, Snyder, Lawrence B, Willard, Ryan R, Vitale, Nicholas, Raina, Kanak, Pizzano, Jennifer, Gordon, Deborah A, Bookbinder, Mark, Macaluso, Jennifer, Dong, Hanqing, Liu, Zheng, Ferraro, Caterina, Wang, Gan, Wang, Jing, Crews, Craig M, Houston, John, Crew, Andrew P, Taylor, Ian

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Abstract 5637: An oral Androgen Receptor PROTAC degrader for prostate cancer von Neklesa, Taavi K., Snyder, Lawrence B., Bookbinder, Mark, Chen, Xin, Crew, Andrew P., Crews, Craig M., Dong, Hanqing, Gordon, Deborah, Macaluso, Jennifer, Raina, Kanak, Rossi, AnnMarie, Taylor, Ian, Vitale, Nicholas, Wang, Jing, Willard, Ryan R., Zimmermann, Kurt

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An oral androgen receptor PROTAC degrader for prostate cancer von Neklesa, Taavi K, Snyder, Lawrence B, Bookbinder, Mark, Chen, Xin, Crew, Andrew P, Crews, Craig M, Dong, Hanqing, Gordon, Deborah A, Raina, Kanak, Rossi, AnnMarie K, Taylor, Ian, Vitale, Nicholas, Wang, Jing, Willard, Ryan R, Zimmermann, Kurt

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BREAST CANCER TREATMENT METHOD von WILLARD, Ryan

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ARV-330: Androgen receptor PROTAC degrader for prostate cancer von Neklesa, Taavi K, Jin, Meizhong, Crew, Andrew P, Rossi, AnnMarie K, Willard, Ryan R, Dong, Hanqing, Siu, Kam, Wang, Jing, Gordon, Deborah A, Chen, Xin, Ferraro, Caterina, Crews, Craig M, Coleman, Kevin, Winkler, James D.

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Abstract LB-097: Targeted degradation of the androgen receptor in prostate cancer von Jin, Meizhong, Winkler, James D., Coleman, Kevin, Crew, Andrew P., Rossi, AnnMarie K., Willard, Ryan R., Dong, Hanqing, Siu, Kam, Wang, Jing, Gordon, Deborah A., Chen, Xin, Ferraro, Caterina, Crews, Craig M., Neklesa, Taavi K.

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