Design and Synthesis of New Enzymes Based on the Lactate Dehydrogenase Framework von Dunn, C. R., Wilks, H. M., Halsall, D. J., Atkinson, T., Clarke, A. R., Muirhead, H., Holbrook, J. J.

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A Specific, Highly Active Malate Dehydrogenase by Redesign of a Lactate Dehydrogenase Framework von Wilks, Helen M., Hart, Keith W., Feeney, Raymond, Dunn, Cameron R., Muirhead, Hilary, Chia, William N., Barstow, David A., Atkinson, Tony, Clarke, Anthony R., Holbrook, J. John

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A light-dependent complementation system for analysis of NADPH:protochlorophyllide oxidoreductase: identification and mutagenesis of two conserved residues that are essential for e... von Wilks, H.M. (University of Virginia, Charlottesville, VA.), Timko, M.P

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Designs for a broad substrate specificity keto acid dehydrogenase von Wilks, Helen M, Halsall, David J, Atkinson, Tony, Chia, William N, Clarke, Anthony R, Holbrook, J. John

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An investigation of the contribution made by the carboxylate group of an active site histidine-aspartate couple to binding and catalysis in lactate dehydrogenase von Clarke, Anthony R, Wilks, Helen M, Barstow, David A, Atkinson, Tony, Chia, William N, Holbrook, J. John

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NADPH:protochlorophyllide oxidoreductase from Synechocystis: overexpression, purification and preliminary characterisation von Heyes, Derren J., Martin, Giles E.M., Reid, R.James, Hunter, C.Neil, Wilks, Helen M.

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Purification and kinetic analysis of pea (Pisum sativum L.) NADPH:protochlorophyllide oxidoreductase expressed as a fusion with maltose-binding protein in Escherichia coli von Martin, G E, Timko, M P, Wilks, H M

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Design of a specific phenyllactate dehydrogenase by peptide loop exchange on the Bacillus stearothermophilus lactate dehydrogenase framework von Wilks, Helen M, Moreton, Kathleen M, Halsall, David J, Hart, Keith W, Sessions, Richard D, Clarke, Anthony R, Holbrook, J. John

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The role of protein surface charge in catalytic activity and chloroplast membrane association of the pea NADPH: protochlorophyllide oxidoreductase (POR) as revealed by alanine scan... von Dahlin, C. (Goeteborg Univ. (Sweden). Dept. of Plant Physiology), Aronsson, H, Wilks, H.M, Lebedev, N, Sundqvist, C, Timko, M.P

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Construction of a stable dimer of Bacillus stearothermophilus lactate dehydrogenase von Jackson, Richard M, Gelpi, Josep L, Cortes, Antonio, Emery, David C, Wilks, Helen M, Moreton, Kathleen M, Halsall, David J, Sleigh, Roger N, Behan-Martin, Moira

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Opportunities and limits in creating new enzymes. Experiences with the NAD-dependent lactate dehydrogenase frameworks of humans and bacteria von Wilks, H M, Cortes, A, Emery, D C, Halsall, D J, Clarke, A R, Holbrook, J J

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Rational construction of a 2-hydroxyacid dehydrogenase with new substrate specificity von Clarke, Anthony R., Smith, Corinne J., Hart, Keith W., Wilks, Helen M., Chia, William N., Lee, Thomas V., Birktoft, Jens J., Banaszak, Leonard J., Barstow, David A., Atkinson, Tony, Holbrook, J.John

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Enzymology below 200 K: The Kinetics and Thermodynamics of the Photochemistry Catalyzed by Protochlorophyllide Oxidoreductase von Heyes, Derren J., Ruban, Alexander V., Wilks, Helen M., Hunter, C. Neil

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Alteration of enzyme specificity and catalysis by protein engineering von Wilks, Helen M., Holbrook, J.John

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On the effect on specificity of Thr246→Gly mutation in L-lactate dehydrogenase of Bacillus stearothermophilus von BUR, D, CLARKE, T, FRIESEN, J. D, GOLD, M, HART, K. W, HOLBROOK, J. J, JONES, J. B, LUYTEN, M. A, WILKS, H. M

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Opportunities and Limits in Creating New Enzymes von WILKS, H. M., CORTES, A., EMERY, D. C., HALSALL, D. J., CLARKE, A. R., HOLBROOK, J. J.

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Enzymic catalysis - Design and synthesis of new enzymes based on the lactate dehydrogenase framework von Dunn, C. R., Wilks, H. M., Halsall, D. J., Atkinson, T., Clarke, A. R., Muirhead, Hilary, Holbrook, J. J.

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Teams, performance and trust: a perspective from the vanguard von James, OP, Bowman, CR, Parker, J, Luton, O, Robinson, DBT, Hopkins, L, Powell, AGMT, Egan, RJ, Lewis, WG

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On the effect on specificity of Thr246----Gly mutation in L-lactate dehydrogenase of Bacillus sterothermophilus von Bur, D, Clarke, T, Friesen, J D, Gold, M, Hart, K W, Holbrook, J J, Jones, J B, Luyten, M A, Wilks, H M

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On the effect on specificity of Thr246 arrow right Gly mutation in L-lactate dehydrogenase of Bacillus stearothermophilus von Bur, D, Clarke, T, Friesen, J D, Gold, M, Hart, K W, Holbrook, J J, Jones, J B, Luyten, MA, Wilks, H M

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