Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946) von Scott, William J., Hentemann, Martin F., Rowley, R. Bruce, Bull, Cathy O., Jenkins, Susan, Bullion, Ann M., Johnson, Jeffrey, Redman, Anikó, Robbins, Arthur H., Esler, William, Fracasso, R. Paul, Garrison, Timothy, Hamilton, Mark, Michels, Martin, Wood, Jill E., Wilkie, Dean P., Xiao, Hong, Levy, Joan, Stasik, Enrico, Liu, Ningshu, Schaefer, Martina, Brands, Michael, Lefranc, Julien

Volltext

BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models von Liu, Ningshu, Rowley, Bruce R, Bull, Cathy O, Schneider, Claudia, Haegebarth, Andrea, Schatz, Christoph A, Fracasso, Paul R, Wilkie, Dean P, Hentemann, Martin, Wilhelm, Scott M, Scott, William J, Mumberg, Dominik, Ziegelbauer, Karl

Volltext

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production von LaBranche, Timothy P., Jesson, Michael I., Radi, Zaher A., Storer, Chad E., Guzova, Julia A., Bonar, Sheri L., Thompson, Janice M., Happa, Fernando A., Stewart, Zachary S., Zhan, Yutian, Bollinger, Chris S., Bansal, Prashant N., Wellen, Jeremy W., Wilkie, Dean P., Bailey, Steven A., Symanowicz, Peter T., Hegen, Martin, Head, Richard D., Kishore, Nandini, Mbalaviele, Gabriel, Meyer, Debra M.

Volltext

Diversity of human pancreatic cancer cell proteinases: role of cell membrane metalloproteinases in collagenolysis and cytolysis von ZUCKER, S, LYSIK, R. M, WIEMAN, J, WILKIE, D. P, LANE, B

Volltext

Metastatic mouse melanoma cells release collagen-gelatin degrading metalloproteinases as components of shed membrane vesicles von Zucker, Stanley, Wieman, Janine M., Lysik, Rita M., Wilkie, Dean P., Ramamurthy, Nangavaram, Lane, Bernard

Volltext

Diversity of Melanoma Plasma Membrane Proteinases: Inhibition of Collagenolytic and Cytolytic Activities by Minocycline von Zucker, Stanley, Lysik, Rita M., Ramamurthy, Nungavaram S., Golub, Lorne M., Wieman, Janine M., Wilkie, Dean P.

Volltext

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis von WILHELM, Scott M, CARTER, Christopher, CAO, Yichen, SHUJATH, Jaleel, GAWLAK, Susan, EVELEIGH, Deepa, ROWLEY, Bruce, LI LIU, ADNANE, Lila, LYNCH, Mark, AUCLAIR, Daniel, TAYLOR, Ian, TANG, Liya, GEDRICH, Rich, VOZNESENSKY, Andrei, RIEDL, Bernd, POST, Leonard E, BOLLAG, Gideon, TRAIL, Pamela A, WILKIE, Dean, MCNABOLA, Angela, HONG RONG, CHEN, Charles, XIAOMEI ZHANG, VINCENT, Patrick, MCHUGH, Mark

Volltext

The impact of broadening COVID-19 testing eligibility on communities of color – A lesson for overcoming structural barriers to health care von Perez, Numa P., Xerras, Dean C., Aldrich, Leslie S., Wilkie, Sarah, Tan-McGrory, Aswita, Betancourt, Joseph R., Masiakos, Peter T.

Volltext

Use of Rat Primary Mesenteric Cells for the Prediction of PDE4 Inhibitor Drug-Induced Vascular Injury von Gosink, Mark M, Chapin, Robert E, Wilkie, Dean, Davenport, Scott, Kumpf, Steven W, Enerson, Bradley E, Houle, Christopher, Koza-Taylor, Petra, Wisialowski, Todd A, Lawton, Michael P

Volltext

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model von Bagi, Cedo M, Christensen, James, Cohen, Darrel P, Roberts, Walter G, Wilkie, Dean, Swanson, Terri, Tuthill, Theresa, Andresen, Catharine J

Volltext

New Insights on the Pathogenesis and Treatment of Crystal Arthritis von Richette, P., McCarthy, G., Doherty, M., Husted, H., Jameson, S., Reed, M., Murray Brunt, A., Bosworth, A., Buch, M., Symmons, D., Row, I., Dawes, P., Bower, P., Porter, T., Sanders, T., Nio Ong, B., Cheraghi-Sohi, S., Kennedy, A., Morden, A., Rogers, A., Richardson, J., Stevenson, F., Weinman, J., Cordingley, L., Dean, S., Hosking, D. J., Aihie Sayer, A., Compston, J., Mukhtyar, C., Bruce, I., Thachil, J., Wilkie, R., Black, D. C., Gunnyeon, B., Walker, D., Higginbottom, A., Flurey, C. A., Hewlett, S., Ricketts, B., Gordon, C.

Volltext

63. The renal uptake quotient (RUQ) – clinical evaluation von Wilkie, M E, Newell, M S, Dean, P M, Marsh, F P, Garvie, N W

Volltext