Combined targeting of the BRD4-NUT-p300 axis in NUT midline carcinoma by dual selective bromodomain inhibitor, NEO2734 von Morrison-Smith, Chevaun D, Knox, Tatiana M, Filic, Ivona, Soroko, Kara M, Eschle, Benjamin K, Wilkens, Margaret K, Gokhale, Prafulla C, Giles, Francis, Griffin, Andrew, Brown, Bill, Shapiro, Geoffrey I, Zucconi, Beth E, Cole, Philip A, Lemieux, Madeleine E, French, Christopher A

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Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations von Ogino, Atsuko, Choi, Jihyun, Lin, Mika, Wilkens, Margaret K., Calles, Antonio, Xu, Man, Adeni, Anika E., Chambers, Emily S., Capelletti, Marzia, Butaney, Mohit, Gray, Nathanael S., Gokhale, Prafulla C., Palakurthi, Sangeetha, Kirschmeier, Paul, Oxnard, Geoffrey R., Sholl, Lynette M., Jänne, Pasi A.

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Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma von Iorgulescu, J Bryan, Gokhale, Prafulla C, Speranza, Maria C, Eschle, Benjamin K, Poitras, Michael J, Wilkens, Margaret K, Soroko, Kara M, Chhoeu, Chhayheng, Knott, Aine, Gao, Yan, Lim-Fat, Mary Jane, Baker, Gregory J, Bonal, Dennis M, Nguyen, Quang-Dé, Grant, Gareth R L, Ligon, Keith L, Sorger, Peter K, Chiocca, E Antonio, Anderson, Ana C, Kirschmeier, Paul T, Sharpe, Arlene H, Freeman, Gordon J, Reardon, David A

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ERK Inhibitor LY3214996-Based Treatment Strategies for RAS -Driven Lung Cancer von Köhler, Jens, Zhao, Yutong, Li, Jiaqi, Gokhale, Prafulla C, Tiv, Hong L, Knott, Aine R, Wilkens, Margaret K, Soroko, Kara M, Lin, Mika, Ambrogio, Chiara, Musteanu, Monica, Ogino, Atsuko, Choi, Jihyun, Bahcall, Magda, Bertram, Arrien A, Chambers, Emily S, Paweletz, Cloud P, Bhagwat, Shripad V, Manro, Jason R, Tiu, Ramon V, Jänne, Pasi A

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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway von Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.

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Abstract 955: Combined inhibition of MEK and mTOR pathways is effective in NRAS Q61K mutant small cell lung cancer von Ogino, Atsuko, Lin, Mika, Gokhale, Prafulla C., Wilkens, Margaret K., Choi, Jihyun, Calles, Antonio, Xu, Man, Capelletti, Marzia, Oxnard, Geoffrey, Gray, Nathanael S., Kirschmeier, Paul, Jänne, Pasi A.

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Abstract 372: Optimizing vertical MAPK pathway inhibition for RAS mutant non-small cell lung cancer von Köhler, Jens, Paweletz, Cloud P., Kuang, Yanan, Gokhale, Prafulla, Wilkens, Margaret K., Tiv, Hong, Ogino, Atsuko, Choi, Jihyun, Kirschmeier, Paul T., Jänne, Pasi A.

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IMMU-19. PD-1 BLOCKADE ACTIVATES CD4 T CELLS AND THE INNATE IMMUNE RESPONSE FOR GLIOBLASTOMA ERADICATION von Speranza, Maria Carmela, Klein, Sarah R, Gokhale, Prafulla C, Wilkens, Margaret K, Jones, Kristen L, Chaudhri, Apoorvi, Kirschmeier, Paul T, Reardon, David, Freeman, Gordon

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Abstract 5467: Efficacy of the ERK inhibitor LY3214996 and the PI3K/mTOR inhibitor LY3023414 in patient-derived RAS- mutant NSCLC models von Köhler, Jens, Gokhale, Prafulla C., Li, Jiaqi, Wilkens, Margaret K., Tiv, Hong, Bhagwat, Shripad V., Donoho, Greg, Brueck, Patrick, Tiu, Ramon V., Redig, Amanda J., Chambers, Emily S., Ogino, Atsuko, Choi, Jihyun, Xu, Man, Kirschmeier, Paul, Jänne, Pasi A.

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IMMU-15. PD-1 BLOCKADE ACTIVATES CD4 T CELLS AND THE INNATE IMMUNE RESPONSE FOR GLIOBLASTOMA ERADICATION von Klein, Sarah R, Speranza, Maria Carmela, Gokhale, Prafulla C, Wilkens, Margaret K, Jones, Kristen L, Kirschmeier, Paul T, Chaudhri, Apoorvi, Reardon, David, Freeman, Gordon J

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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes von McKay, James D, Hung, Rayjean J, Han, Younghun, Zong, Xuchen, Christiani, David C, Johansson, Mattias, Byun, Jinyoung, Dunning, Alison, Qian, David C, Bojesen, Stig E, Wu, Xifeng, Bickeböller, Heike, Aldrich, Melinda C, Bush, William S, Tardon, Adonina, Teare, M Dawn, Field, John K, Kiemeney, Lambertus A, Lazarus, Philip, Shen, Hongbing, Yuan, Jian-Min, Bertazzi, Pier Alberto, Pesatori, Angela C, Ye, Yuanqing, Brhane, Yonathan, Johansen, Jakob S, Saliba, Walid, Haiman, Christopher A, Wilkens, Lynne R, Fernandez-Somoano, Ana, van der Heijden, Henricus F M, Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P A, Marcus, Michael W, Brunnström, Hans, Manjer, Jonas, Muller, David C, Trichopoulou, Antonia, Tumino, Rosario, Barnett, Matt P, Chen, Chu, Goodman, Gary E, Taylor, Fiona, Woll, Penella, Brüske, Irene, Wichmann, H-Erich, Muley, Thomas R, Risch, Angela, Grankvist, Kjell, Shepherd, Frances A, Tsao, Ming-Sound, Arnold, Susanne M, Haura, Eric B, Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M, Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Skaug, Vidar, Zienolddiny, Shanbeh, Butler, Lesley M, Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard S, McLaughlin, John, Joubert, Philippe, Lamontagne, Maxime, Nickle, David C, Zhu, Bin, Song, Lei, Kachuri, Linda, Artigas, María Soler, Tobin, Martin D, Wain, Louise V, Rafnar, Thorunn, Reginsson, Gunnar W, Stefansson, Kari, Hancock, Dana B, Bierut, Laura J, Lutz, Sharon M, Gu, Fangyi, Johnson, Eric O, Pikielny, Claudio, Lindströem, Sara, Jiang, Xia, Tyndale, Rachel F, Chenevix-Trench, Georgia, Beesley, Jonathan, Bossé, Yohan, Chanock, Stephen, Brennan, Paul, Landi, Maria Teresa

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Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population von Zanetti, Krista A., Wang, Zhaoming, Aldrich, Melinda, Amos, Christopher I., Blot, William J., Bowman, Elise D., Burdette, Laurie, Cai, Qiuyin, Caporaso, Neil, Chung, Charles C., Gillanders, Elizabeth M., Haiman, Christopher A., Hansen, Helen M., Henderson, Brian E., Kolonel, Laurence N., Marchand, Loic Le, Li, Shengchao, McNeill, Lorna Haughton, Ryan, Bríd M., Schwartz, Ann G., Sison, Jennette D., Spitz, Margaret R., Tucker, Margaret, Wenzlaff, Angela S., Wiencke, John K., Wilkens, Lynne, Wrensch, Margaret R., Wu, Xifeng, Zheng, Wei, Zhou, Weiyin, Christiani, David, Palmer, Julie R., Penning, Trevor M., Rieber, Alyssa G., Rosenberg, Lynn, Ruiz-Narvaez, Edward A., Su, Li, Vachani, Anil, Wei, Yongyue, Whitehead, Alexander S., Chanock, Stephen J., Harris, Curtis C.

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Genome-wide association study confirms lung cancer susceptibility loci on chromosome 5p15 and 15q25 in an African-American population von Zanetti, Krista A, Wang, Zhaoming, Aldrich, Melinda, Amos, Christopher I, Blot, William J, Bowman, Elise D, Burdette, Laurie, Cai, Quiyin, Caporaso, Neil, Chung, Charles C, Gillanders, Elizabeth M, Haiman, Christopher A, Hansen, Helen M, Henderson, Brian E, Kolonel, Laurence N, Marchand, Loic Le, Li, Shengchao, McNeill, Lorna Haughton, Ryan, Bríd M, Schwartz, Ann G, Sison, Jennette D, Spitz, Margaret R, Tucker, Margaret, Wenzlaff, Angela S, Wiencke, John K, Wilkens, Lynne, Wrensch, Margaret R, Wu, Xifeng, Zheng, Wei, Zhou, Weiyin, Christiani, David, Palmer, Julie R, Penning, Trevor M, Rieber, Alyssa G, Rosenberg, Lynn, Ruiz-Narvaez, Edward A, Su, Li, Vachani, Anil, Wei, Yongyue, Whitehead, Alexander S, Chanock, Stephen J, Harris, Curtis C

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Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia von Brenner, Darren R, Amos, Christopher I, Brhane, Yonathan, Timofeeva, Maria N, Caporaso, Neil, Wang, Yufei, Christiani, David C, Bickeböller, Heike, Yang, Ping, Albanes, Demetrius, Stevens, Victoria L, Gapstur, Susan, McKay, James, Boffetta, Paolo, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Krokan, Hans E, Skorpen, Frank, Gabrielsen, Maiken E, Vatten, Lars, Njølstad, Inger, Chen, Chu, Goodman, Gary, Lathrop, Mark, Vooder, Tõnu, Välk, Kristjan, Nelis, Mari, Metspalu, Andres, Broderick, Peter, Eisen, Timothy, Wu, Xifeng, Zhang, Di, Chen, Wei, Spitz, Margaret R, Wei, Yongyue, Su, Li, Xie, Dong, She, Jun, Matsuo, Keitaro, Matsuda, Fumihiko, Ito, Hidemi, Risch, Angela, Heinrich, Joachim, Rosenberger, Albert, Muley, Thomas, Dienemann, Hendrik, Field, John K, Raji, Olaide, Chen, Ying, Gosney, John, Liloglou, Triantafillos, Davies, Michael P A, Marcus, Michael, McLaughlin, John, Orlow, Irene, Han, Younghun, Li, Yafang, Zong, Xuchen, Johansson, Mattias, Liu, Geoffrey, Tworoger, Shelley S, Le Marchand, Loic, Henderson, Brian E, Wilkens, Lynne R, Dai, Juncheng, Shen, Hongbing, Houlston, Richard S, Landi, Maria T, Brennan, Paul, Hung, Rayjean J

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