Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells von Lloyd, Rebecca L., Wijnhoven, Paul W. G., Ramos-Montoya, Antonio, Wilson, Zena, Illuzzi, Giuditta, Falenta, Katarzyna, Jones, Gemma N., James, Neil, Chabbert, Christophe D., Stott, Jonathan, Dean, Emma, Lau, Alan, Young, Lucy A.

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p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity von Adriaens, Carmen, Standaert, Laura, Barra, Jasmine, Latil, Mathilde, Verfaillie, Annelien, Kalev, Peter, Boeckx, Bram, Wijnhoven, Paul W G, Radaelli, Enrico, Vermi, William, Leucci, Eleonora, Lapouge, Gaëlle, Beck, Benjamin, van den Oord, Joost, Nakagawa, Shinichi, Hirose, Tetsuro, Sablina, Anna A, Lambrechts, Diether, Aerts, Stein, Blanpain, Cédric, Marine, Jean-Christophe

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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity von Fok, Jacqueline H. L., Ramos-Montoya, Antonio, Vazquez-Chantada, Mercedes, Wijnhoven, Paul W. G., Follia, Valeria, James, Neil, Farrington, Paul M., Karmokar, Ankur, Willis, Sophie E., Cairns, Jonathan, Nikkilä, Jenni, Beattie, David, Lamont, Gillian M., Finlay, M. Raymond V., Wilson, Joanne, Smith, Aaron, O’Connor, Lenka Oplustil, Ling, Stephanie, Fawell, Stephen E., O’Connor, Mark J., Hollingsworth, Simon J., Dean, Emma, Goldberg, Frederick W., Davies, Barry R., Cadogan, Elaine B.

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ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib von Wilson, Zena, Odedra, Rajesh, Wallez, Yann, Wijnhoven, Paul W G, Hughes, Adina M, Gerrard, Joe, Jones, Gemma N, Bargh-Dawson, Hannah, Brown, Elaine, Young, Lucy A, O'Connor, Mark J, Lau, Alan

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Synthetic lethality between PAXX and XLF in mammalian development von Balmus, Gabriel, Barros, Ana C, Wijnhoven, Paul W G, Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, le Sage, Carlos, Doe, Brendan, Speak, Anneliese O, Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J, Blackford, Andrew N, Jackson, Stephen P

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The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage von Nishi, Ryotaro, Wijnhoven, Paul W. G., Kimura, Yusuke, Matsui, Misaki, Konietzny, Rebecca, Wu, Qian, Nakamura, Keisuke, Blundell, Tom L., Kessler, Benedikt M.

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C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption von Sharma, Abhishek Bharadwaj, Ramlee, Muhammad Khairul, Kosmin, Joel, Higgs, Martin R., Wolstenholme, Amy, Ronson, George E., Jones, Dylan, Ebner, Daniel, Shamkhi, Noor, Sims, David, Wijnhoven, Paul W. G., Forment, Josep V., Gibbs-Seymour, Ian, Lakin, Nicholas D.

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Author Correction: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption von Sharma, Abhishek Bharadwaj, Ramlee, Muhammad Khairul, Kosmin, Joel, Higgs, Martin R., Wolstenholme, Amy, Ronson, George E., Jones, Dylan, Ebner, Daniel, Shamkhi, Noor, Sims, David, Wijnhoven, Paul W. G., Forment, Josep V., Gibbs-Seymour, Ian, Lakin, Nicholas D.

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Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance von Serra, Violeta, Wang, Anderson T, Castroviejo-Bermejo, Marta, Polanska, Urszula M, Palafox, Marta, Herencia-Ropero, Andrea, Jones, Gemma N, Lai, Zhongwu, Armenia, Joshua, Michopoulos, Filippos, Llop-Guevara, Alba, Brough, Rachel, Gulati, Aditi, Pettitt, Stephen J, Bulusu, Krishna C, Nikkilä, Jenni, Wilson, Zena, Hughes, Adina, Wijnhoven, Paul W G, Ahmed, Ambar, Bruna, Alejandra, Gris-Oliver, Albert, Guzman, Marta, Rodríguez, Olga, Grueso, Judit, Arribas, Joaquin, Cortés, Javier, Saura, Cristina, Lau, Alan, Critchlow, Susan, Dougherty, Brian, Caldas, Carlos, Mills, Gordon B, Barrett, J Carl, Forment, Josep V, Cadogan, Elaine, Lord, Christopher J, Cruz, Cristina, Balmaña, Judith, O'Connor, Mark J

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Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development von Gill, Sonja J., Wijnhoven, Paul W. G., Fok, Jacqueline H. L., Lloyd, Rebecca L., Cairns, Jonathan, Armenia, Joshua, Nikkila, Jenni, Lau, Alan, Bakkenist, Christopher J., Galbraith, Susan M., Vens, Conchita, O'Connor, Mark J.

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Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity von Nishi, Ryotaro, Wijnhoven, Paul, le Sage, Carlos, Tjeertes, Jorrit, Galanty, Yaron, Forment, Josep V., Clague, Michael J., Urbé, Sylvie, Jackson, Stephen P.

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Publisher Correction: p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity von Adriaens, Carmen, Standaert, Laura, Barra, Jasmine, Latil, Mathilde, Verfaillie, Annelien, Kalev, Peter, Boeckx, Bram, Wijnhoven, Paul. W. G, Radaelli, Enrico, Vermi, William, Leucci, Eleonora, Lapouge, Gaëlle, Beck, Benjamin, van den Oord, Joost, Nakagawa, Shinichi, Hirose, Tetsuro, Sablina, Anna. A, Lambrechts, Diether, Aerts, Stein, Blanpain, Cédric, Marine, Jean-Christophe

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Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer von Asim, Mohammad, Tarish, Firas, Zecchini, Heather I., Sanjiv, Kumar, Gelali, Eleni, Massie, Charles E., Baridi, Ajoeb, Warren, Anne Y., Zhao, Wanfeng, Ogris, Christoph, McDuffus, Leigh-Anne, Mascalchi, Patrice, Shaw, Greg, Dev, Harveer, Wadhwa, Karan, Wijnhoven, Paul, Forment, Josep V., Lyons, Scott R., Lynch, Andy G., O’Neill, Cormac, Zecchini, Vincent R., Rennie, Paul S., Baniahmad, Aria, Tavaré, Simon, Mills, Ian G., Galanty, Yaron, Crosetto, Nicola, Schultz, Niklas, Neal, David, Helleday, Thomas

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USP4 Auto-Deubiquitylation Promotes Homologous Recombination von Wijnhoven, Paul, Konietzny, Rebecca, Blackford, Andrew N., Travers, Jonathan, Kessler, Benedikt M., Nishi, Ryotaro, Jackson, Stephen P.

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Abstract 626: Mechanistic differentiation of targeted DDR agent combinations von Forment, Josep V., Wijnhoven, Paul, Ramos-Montoya, Antonio, Fok, Jacqueline, Follia, Valeria, Vazquez-Chantada, Mercedes, Oderda, Rajesh, Wilson, Zena, Lau, Alan, Leo, Elisabetta, Durant, Stephen, Cadogan, Elaine, O'Connor, Mark J.

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Abstract 337: The PARP inhibitor olaparib is synergistic with the ATR inhibitor AZD6738 in ATM deficient cancer cells von Lloyd, Rebecca, Falenta, Katarynza, Wijnhoven, Paul W., Chabbert, Christophe, Stott, Jonathan, Yates, James, Lau, Alan Y., Young, Lucy A., Hollingsworth, Simon J.

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Abstract 3506: AZD7648, a potent and selective inhibitor of DNA-PK, potentiates activity of the PARP inhibitor olaparib resulting in sustained anti-tumour activity in xenograft and... von Ramos-Montoya, Antonio, Fok, Jacqueline H., James, Neil, Follia, Valeria, Vazquez-Chantada, Mercedes, Wijnhoven, Paul, O’Connor, Lenka Oplustil, Karmokar, Ankur, Staniszewska, Anna, Dean, Emma, Hollingsworth, Simon J., Davies, Barry, Cadogan, Elaine B.

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Abstract LB-176: The human androgen receptor regulates DNA damage response (DDR) in prostate cancer von Asim, Mohammad, Zecchini, Heather, Tarish, Firas, Massie, Charlie, Baridi, Ajoeb, Warren, Anne, Zhao, Wanfeng, McDuffus, Leigh-Anne, Mascalchi, Patrice, Shaw, Greg, Dev, Harveer, Wadhwa, Karan, Wijnhoven, Paul, Forment, Josep, Lyons, Scott, Lynch, Andy, O’Neill, Cormac, Zecchini, Vincent, Rennie, Paul, Baniahmad, Aria, Tavare, Simon, Mills, Ian, Schulz, Niklas, Galanty, Yaron, Helleday, Thomas, Neal, David

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p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity von Adriaens, Carmen, Standaert, Laura, Barra, Jasmine, Latil, Mathilde, Verfaillie, Annelien, Kalev, Peter, Boeckx, Bram, Wijnhoven, Paul W.G, Radaelli, Enrico, Vermi, William, Leucci, Eleonora, Lapouge, Gaëlle, Beck, Benjamin, van den Oord, Joost, Nakagawa, Shinichi, Hirose, Tetsuro, Sablina, Anna, Lambrechts, Diether, Aerts, Stein, Blanpain, Cédric, Marine, Chris

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Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells von Lloyd, Rebecca L, Wijnhoven, Paul WG, Ramos-Montoya, Antonio, Wilson, Zena, Illuzzi, Giuditta, Falenta, Katarzyna, Jones, Gemma N, James, Neil, Chabbert, Christophe D, Stott, Jonathan, Dean, Emma, Lau, Alan, Young, Lucy A

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