The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome von Watson, Patrice, Vasen, Hans F.A., Mecklin, Jukka‐Pekka, Bernstein, Inge, Aarnio, Markku, Järvinen, Heikki J., Myrhøj, Torben, Sunde, Lone, Wijnen, Juul T., Lynch, Henry T.

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Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers von Jansen, Anne Ml, van Wezel, Tom, van den Akker, Brendy Ewm, Ventayol Garcia, Marina, Ruano, Dina, Tops, Carli Mj, Wagner, Anja, Letteboer, Tom Gw, Gómez-García, Encarna B, Devilee, Peter, Wijnen, Juul T, Hes, Frederik J, Morreau, Hans

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The complexity of screening PMS2 in DNA isolated from formalin-fixed paraffin-embedded material von Jansen, Anne M. L., Tops, Carli M. J., Ruano, Dina, van Eijk, Ronald, Wijnen, Juul T., ten Broeke, Sanne, Nielsen, Maartje, Hes, Frederik J., van Wezel, Tom, Morreau, Hans

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A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome patients harbouring pathogenic MSH2 variants von Wiik, Mariann Unhjem, Evans, Tiffany-Jane, Belhadj, Sami, Bolton, Katherine A., Dymerska, Dagmara, Jagmohan-Changur, Shantie, Capellá, Gabriel, Kurzawski, Grzegorz, Wijnen, Juul T., Valle, Laura, Vasen, Hans F. A., Lubinski, Jan, Scott, Rodney J., Talseth-Palmer, Bente A.

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Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort von MIDDELDORP, Anneke, JAGMOHAN-CHANGUR, Shantie, WIJNEN, Juul T, MORREAU, Hans, VAN WEDEL, Tom, VAN EIJK, Ronald, TOPS, Carli, DEVILEE, Peter, VASEN, Hans F. A, HES, Frederik J, HOULSTON, Richard, TOMLINSON, Ian, HOUWING-DUISTERMAAT, Jeanine J

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Exome sequencing of germline DNA from non-BRCA1/2 familial breast cancer cases selected on the basis of aCGH tumor profiling von Hilbers, Florentine S, Meijers, Caro M, Laros, Jeroen F J, van Galen, Michiel, Hoogerbrugge, Nicoline, Vasen, Hans F A, Nederlof, Petra M, Wijnen, Juul T, van Asperen, Christi J, Devilee, Peter

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Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer von Elsayed, Fadwa A, Kets, C Marleen, Ruano, Dina, van den Akker, Brendy, Mensenkamp, Arjen R, Schrumpf, Melanie, Nielsen, Maartje, Wijnen, Juul T, Tops, Carli M, Ligtenberg, Marjolijn J, Vasen, Hans F A, Hes, Frederik J, Morreau, Hans, van Wezel, Tom

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A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 von Koessler, Thibaud, Chandler, Ian, Buch, Stephan, Agúndez, Jose AG, Caldés, Trinidad, Howarth, Kimberley, Walther, Axel, Ladero, Jose M, Morreau, Hans, Giles, Graham G, Cazier, Jean-Baptiste, Castells, Antoni, Maher, Eamonn R, Wood, Wendy, Försti, Asta, Southey, Melissa C, Broderick, Peter, Hopper, John L, de la Hoya, Miguel, Webb, Emily, Wijnen, Juul T, Aaltonen, Lauri, Dunlop, Malcolm G, John, Ulrich, Fielding, Sarah, Barnetson, Rebecca A, Barclay, Ella, Martin, Lynn, Bishop, D Timothy, Tuupanen, Sari, Tenesa, Albert, Jaeger, Emma, Cheng, K K, Niittymäki, Iina, Karhu, Auli, Schreiber, Stefan, Peto, Julian, Völzke, Henry, Schafmayer, Clemens, Luk, J, Vodicka, Pavel, Vijayakrishnan, Jayaram, Carracedo, Angel, Houlston, Richard S, Tomlinson, Ian PM, Rowan, Andrew, Ruiz-Ponte, Clara, Ho, Judy WC, Kemp, Zoe, Lipton, Lara, Sullivan, Kate, Penegar, Steven, Prendergast, James GD, Carvajal-Carmona, Luis, Hampe, Jochen, Sham, Pak C, Kerr, David, Pharoah, Paul, Severi, Gianluca, Campbell, Harry, Pittman, Alan M, Gray, Richard, Castellví-Bel, Sergi, Spain, Sarah, Domingo, Enric, Hemminki, Kari, Lubbe, Steven, Thomas, Huw, van Wezel, Tom, Naccarati, Alessio, Gorman, Maggie, Lucassen, Anneke, Farrington, Susan M, Qureshi, Mobshra, Evans, D Gareth R

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Distinct Patterns of Somatic Mosaicism in the APC Gene in Neoplasms From Patients With Unexplained Adenomatous Polyposis von Jansen, Anne M.L, Crobach, Stijn, Geurts-Giele, Willemina R.R, van den Akker, Brendy E.W.M, Garcia, Marina Ventayol, Ruano, Dina, Nielsen, Maartje, Tops, Carli M.J, Wijnen, Juul T, Hes, Frederik J, van Wezel, Tom, Dinjens, Winand N.M, Morreau, Hans

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Insertion of an SVA element, a nonautonomous retrotransposon, in PMS2 intron 7 as a novel cause of lynch syndrome von van der Klift, Heleen M., Tops, Carli M., Hes, Frederik J., Devilee, Peter, Wijnen, Juul T.

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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ von Pahl, Jens H W, Kwappenberg, Kitty M C, Varypataki, Eleni M, Santos, Susy J, Kuijjer, Marieke L, Mohamed, Susan, Wijnen, Juul T, van Tol, Maarten J D, Cleton-Jansen, Anne-Marie, Egeler, R Maarten, Jiskoot, Wim, Lankester, Arjan C, Schilham, Marco W

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Validation and Implementation of BRCA1/2 Variant Screening in Ovarian Tumor Tissue von de Jonge, Marthe M., Ruano, Dina, van Eijk, Ronald, van der Stoep, Nienke, Nielsen, Maartje, Wijnen, Juul T., ter Haar, Natalja T., Baalbergen, Astrid, Bos, Monique E.M.M., Kagie, Marjolein J., Vreeswijk, Maaike P.G., Gaarenstroom, Katja N., Kroep, Judith R., Smit, Vincent T.H.B.M., Bosse, Tjalling, van Wezel, Tom, van Asperen, Christi J.

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Intronic variants in BRCA1 and BRCA2 that affect RNA splicing can be reliably selected by splice-site prediction programs von Vreeswijk, Maaike P.G, Kraan, Jaennelle N, van der Klift, Heleen M, Vink, Geraldine R, Cornelisse, Cees J, Wijnen, Juul T, Bakker, Egbert, van Asperen, Christi J, Devilee, Peter

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RNA analysis of cancer predisposing genes in formalin-fixed paraffin-embedded tissue determines aberrant splicing von Jansen, Anne Ml, van der Klift, Heleen M, Roos, Marieke Ae, van Eendenburg, Jaap Dh, Tops, Carli Mj, Wijnen, Juul T, Hes, Frederik J, Morreau, Hans, van Wezel, Tom

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Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia von Schubert, Stephanie A, Ruano, Dina, Elsayed, Fadwa A, Boot, Arnoud, Crobach, Stijn, Sarasqueta, Arantza Farina, Wolffenbuttel, Bruce, van der Klauw, Melanie M, Oosting, Jan, Tops, Carli M, van Eijk, Ronald, Vasen, Hans Fa, Vossen, Rolf Ham, Nielsen, Maartje, Castellví-Bel, Sergi, Ruiz-Ponte, Clara, Tomlinson, Ian, Dunlop, Malcolm G, Vodicka, Pavel, Wijnen, Juul T, Hes, Frederik J, Morreau, Hans, de Miranda, Noel Fcc, Sijmons, Rolf H, van Wezel, Tom

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Rare variants in XRCC2 as breast cancer susceptibility alleles von Hilbers, Florentine S, Wijnen, Juul T, Hoogerbrugge, Nicoline, Oosterwijk, Jan C, Collee, Margriet J, Peterlongo, Paolo, Radice, Paolo, Manoukian, Siranoush, Feroce, Irene, Capra, Fabio, Couch, Fergus J, Wang, Xianshu, Guidugli, Lucia, Offit, Kenneth, Shah, Sohela, Campbell, Ian G, Thompson, Ella R, James, Paul A, Trainer, Alison H, Gracia, Javier, Benitez, Javier, van Asperen, Christi J, Devilee, Peter

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Splicing analysis for exonic and intronic mismatch repair gene variants associated with Lynch syndrome confirms high concordance between minigene assays and patient RNA analyses von Klift, Heleen M., Jansen, Anne M. L., Steenstraten, Niki, Bik, Elsa C., Tops, Carli M. J., Devilee, Peter, Wijnen, Juul T.

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A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1 von Drost, Mark, Zonneveld, Jos é B.M., van Dijk, Linda, Morreau, Hans, Tops, Carli M., Vasen, Hans F.A., Wijnen, Juul T., de Wind, Niels

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Combined analysis of three lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers von Talseth‐Palmer, Bente A., Wijnen, Juul T., Brenne, Ingvild S., Jagmohan‐Changur, Shantie, Barker, Daniel, Ashton, Katie A., Tops, Carli M., Evans, Tiffany‐Jane, McPhillips, Mary, Groombridge, Claire, Suchy, Janina, Kurzawski, Grzegorz, Spigelman, Allan, Møller, Pål, Morreau, Hans M., Van Wezel, Tom, Lubinski, Jan, Vasen, Hans F.A., Scott, Rodney J.

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Hereditary cancer registries improve the care of patients with a genetic predisposition to cancer: contributions from the Dutch Lynch syndrome registry von Vasen, Hans F. A., Velthuizen, Mary E., Kleibeuker, Jan H., Menko, Fred H., Nagengast, Fokke M., Cats, Annemieke, van der Meulen-de Jong, Andrea E., Breuning, Martijn H., Roukema, Anne J., van Leeuwen-Cornelisse, Inge, de Vos tot Nederveen Cappel, Wouter H., Wijnen, Juul T.

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