Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa von Rezzoagli, Chiara, Archetti, Martina, Mignot, Ingrid, Baumgartner, Michael, Kümmerli, Rolf, Richardson, Lauren A, Wijayatilake, Hashi, Roberts, Roland G

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Drosophila-associated bacteria differentially shape the nutritional requirements of their host during juvenile growth von Consuegra, Jessika, Grenier, Théodore, Baa-Puyoulet, Patrice, Rahioui, Isabelle, Akherraz, Houssam, Gervais, Hugo, Parisot, Nicolas, da Silva, Pedro, Charles, Hubert, Calevro, Federica, Leulier, François

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Swimming motility of a gut bacterial symbiont promotes resistance to intestinal expulsion and enhances inflammation von Wiles, Travis J, Schlomann, Brandon H, Wall, Elena S, Betancourt, Reina, Parthasarathy, Raghuveer, Guillemin, Karen

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Heritable gene expression variability and stochasticity govern clonal heterogeneity in circadian period von Nikhil, K. L, Korge, Sandra, Kramer, Achim, Wijayatilake, Hashi, Alvarez-Garcia, Ines

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Eating breakfast and avoiding late-evening snacking sustains lipid oxidation von Kelly, Kevin Parsons, McGuinness, Owen P, Buchowski, Maciej, Hughey, Jacob J, Chen, Heidi, Powers, James, Page, Terry, Johnson, Carl Hirschie

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A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep von Maluck, Elisabeth, Busack, Inka, Besseling, Judith, Masurat, Florentin, Turek, Michal, Busch, Karl Emanuel, Bringmann, Henrik

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Single-cell in vivo imaging of cellular circadian oscillators in zebrafish von Wang, Haifang, Yang, Zeyong, Li, Xingxing, Huang, Dengfeng, Yu, Shuguang, He, Jie, Li, Yuanhai, Yan, Jun

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Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation von Sakofsky, Cynthia J, Saini, Natalie, Klimczak, Leszek J, Chan, Kin, Malc, Ewa P, Mieczkowski, Piotr A, Burkholder, Adam B, Fargo, David, Gordenin, Dmitry A

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The importance of being second

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Ratiometric GPCR signaling enables directional sensing in yeast von Henderson, Nicholas T, Pablo, Michael, Ghose, Debraj, Clark-Cotton, Manuella R, Zyla, Trevin R, Nolen, James, Elston, Timothy C, Lew, Daniel J

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Structural analyses of the PKA RII[beta] holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fib... von Lu, Tsan-Wen, Aoto, Phillip C, Weng, Jui-Hung, Nielsen, Cole, Cash, Jennifer N, Hall, James, Zhang, Ping, Simon, Sanford M, Cianfrocco, Michael A, Taylor, Susan S, Wijayatilake, Hashi, Alvarez-Garcia, Ines

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Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering von You, Shu-Ting, Jhou, Yu-Ting, Kao, Cheng-Fu, Leu, Jun-Yi

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Diagnosis of latent tuberculosis infection is associated with reduced HIV viral load and lower risk for opportunistic infections in people living with HIV von Kusejko, Katharina, Günthard, Huldrych F, Olson, Gregory S, Zens, Kyra, Darling, Katharine, Khanna, Nina, Furrer, Hansjakob, Vetter, Pauline, Bernasconi, Enos, Vernazza, Pietro, Hoffmann, Matthias, Kouyos, Roger D, Nemeth, Johannes

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Introducing Open Highlights: Highlighting Open Access Research from PLOS and Beyond

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Introducing PLOS Biology's "Research Matters"

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