Protein Based Amorphous Solid Dispersion: a Case Study Investigating Different Whey Proteins at High Drug Loading von Leng, Donglei, Bulduk, Bulut, Widmer, Toni, Wiborg, Ole, Sanchez-Felix, Manuel, Löbmann, Korbinian

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Transformation of acidic poorly water soluble drugs into ionic liquids von Balk, Anja, Wiest, Johannes, Widmer, Toni, Galli, Bruno, Holzgrabe, Ulrike, Meinel, Lorenz

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C von Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M

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Mapping the pharmaceutical design space by amorphous ionic liquid strategies von Wiest, Johannes, Saedtler, Marco, Balk, Anja, Merget, Benjamin, Widmer, Toni, Bruhn, Heike, Raccuglia, Marc, Walid, Elbast, Picard, Franck, Stopper, Helga, Dekant, Wolfgang, Lühmann, Tessa, Sotriffer, Christoph, Galli, Bruno, Holzgrabe, Ulrike, Meinel, Lorenz

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Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor von Fairhurst, Robin A., Furet, Pascal, Imbach-Weese, Patricia, Stauffer, Frédéric, Rueeger, Heinrich, McCarthy, Clive, Ripoche, Sebastien, Oswald, Susanne, Arnaud, Bertrand, Jary, Aline, Maira, Michel, Schnell, Christian, Guthy, Daniel A., Wartmann, Markus, Kiffe, Michael, Desrayaud, Sandrine, Blasco, Francesca, Widmer, Toni, Seiler, Frank, Gutmann, Sascha, Knapp, Mark, Caravatti, Giorgio

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Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo von Velcicky, Juraj, Bodendorf, Ursula, Rigollier, Pascal, Epple, Robert, Beisner, Daniel R, Guerini, Danilo, Smith, Philip, Liu, Bo, Feifel, Roland, Wipfli, Peter, Aichholz, Reiner, Couttet, Philippe, Dix, Ina, Widmer, Toni, Wen, Ben, Brandl, Trixi

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Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic prope... von Brachmann, Saskia M., Weiss, Andreas, Guthy, Daniel A., Beyer, Kim, Voshol, Johannes, Maira, Michel, Prahallad, Anirudh, Porta, Diana Graus, Schnell, Christian, Ostermann, Nils, Vaupel, Andrea, Gerspacher, Marc, Leblanc, Catherine, Erdmann, Dirk, Sterker, Dario, Kerr, Grainne, Jerome, Giovannoni, Head, Victoria, Stringer, Rowan, De Kanter, Ruben, Jeff, Kearns, Roman, Danielle, Widmer, Toni, Wessels, Peter, Nunez, Eloisa Jimenez, Sedrani, Richard, Zecri, Frederic, Hofmann, Francesco, Engleman, Jeff, Lorthiois, Edwige, Cotesta, Simona

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Ionic Liquid Versus Prodrug Strategy to Address Formulation Challenges von Balk, Anja, Widmer, Toni, Wiest, Johannes, Bruhn, Heike, Rybak, Jens-Christoph, Matthes, Philipp, Müller-Buschbaum, Klaus, Sakalis, Anastasios, Lühmann, Tessa, Berghausen, Jörg, Holzgrabe, Ulrike, Galli, Bruno, Meinel, Lorenz

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Abstract 4026: JDQ443, a covalent inhibitor of KRASG12C with a novel binding mode, shows broad antitumor activity in KRASG12C preclinical models as a single agent and in combinatio... von Weiss, Andreas, Voshol, Hans, Porta, Diana Graus, Fedele, Carmine, Sterker, Dario, De Kanter, Ruben, Stringer, Rowan, Widmer, Toni, Loo, Alice, Guthy, Daniel A., Beyer, Kim S., Ostermann, Nils, LeBlanc, Catherine, Gerspacher, Marc, Vaupel, Andrea, Sedrani, Richard, Zecri, Frederic, Maria, Saveur-Michel, Hofmann, Francesco, Hammerman, Peter, Engelman, Jeff, Lorthiois, Edwige, Cotesta, Simona, Brachmann, Saskia M.

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The Binding Mode of Side Chain- and C3-Modified Epothilones to Tubulin von Erdélyi, Máté, Navarro-Vázquez, Armando, Pfeiffer, Bernhard, Kuzniewski, Christian N., Felser, Andrea, Widmer, Toni, Gertsch, Jürg, Pera, Benet, Díaz, José Fernando, Altmann, Karl-Heinz, Carlomagno, Teresa

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Lowering lattice forces in drug substance crystals to improve dissolution and solubility von Widmer, Toni

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Solid Pharmaceutical Composition Comprising PI3K-Inhibitor von Sanchez-Felix Manuel Vincente, Seiler Frank Hans, Verma Daya D, Desai Dipen, Serreau Severine, Shah Navnit H, Graner Oliver, Iyer Raman, Galli Bruno, Meyer Stefanie, Patel Rakesh, Grandolini Simone, Widmer Toni

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SOLID PHARMACEUTICAL COMPOSITION COMPRISING PI3K-INHIBITOR von GALLI, Bruno, SHAH, Navnit H, SANCHEZ-FELIX, Manuel Vincente, PATEL, Rakesh, VERMA, Daya D, GRANER, Oliver, SERREAU, Severine, DESAI, Dipen, SEILER, Frank Hans, WIDMER, Toni, GRANDOLINI, Simone, IYER, Raman, MEYER, Stefanie

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SOLID PHARMACEUTICAL COMPOSITION COMPRISING PI3K-INHIBITOR von MEYER, STEFANIE, GRANDOLINI, SIMONE, SEILER, FRANK HANS, SHAH, NAVNIT H, PATEL, RAKESH, IYER, RAMAN, SERREAU, SEVERINE, GRANER, OLIVER, VERMA, DAYA D, GALLI, BRUNO, DESAI, DIPEN, WIDMER, TONI, SANCHEZ-FELIX, MANUEL VINCENTE

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The binding mode of side chain- and C3-modified epothilones to tubulin von Erdélyi, Máté, Navarro-Vázquez, Armando, Pfeiffer, Bernhard, Kuzniewski, Christian N, Felser, Andrea, Widmer, Toni, Gertsch, Jürg, Pera, Benet, Díaz, José Fernando, Altmann, Karl-Heinz, Carlomagno, Teresa

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Pharmaceutical dosage forms von MEYER, STEFANIE, GRANDOLINI, SIMONE, SEILER, FRANK HANS, PATEL, RAKESH, IYER, RAMAN, SHAH, NAVNIT, VERMA, DAYA, SERREAU, SEVERINE, GRANER, OLIVER, GALLI, BRUNO, DESAI, DIPEN, WIDMER, TONI, SANCHEZ-FELIX, MANUEL VINCENTE

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Antigenic expression and spontaneous immune responses support the use of a selected peptide set from the IMA950 glioblastoma vaccine for immunotherapy of grade II and III glioma von Dutoit, Valérie, Migliorini, Denis, Ranzanici, Giulia, Marinari, Eliana, Widmer, Valérie, Lobrinus, Johannes Alexander, Momjian, Shahan, Costello, Joseph, Walker, Paul R., Okada, Hideho, Weinschenk, Toni, Herold-Mende, Christel, Dietrich, Pierre-Yves

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Data-Efficient Low-Complexity Acoustic Scene Classification in the DCASE 2024 Challenge von Schmid, Florian, Primus, Paul, Heittola, Toni, Mesaros, Annamaria, Martín-Morató, Irene, Koutini, Khaled, Widmer, Gerhard

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Data-Efficient Low-Complexity Acoustic Scene Classification in the DCASE 2024 Challenge von Schmid, Florian, Primus, Paul, Heittola, Toni, Mesaros, Annamaria, Martín-Morató, Irene, Koutini, Khaled, Widmer, Gerhard

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Pina von Wim Wenders

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