Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a von Fukuda, Tetsuya, Chen, Liguang, Endo, Tomoyuki, Tang, Li, Lu, Desheng, Castro, Januario E, Widhopf, George F. II, Rassenti, Laura Z, Cantwell, Mark J, Prussak, Charles E, Carson, Dennis A, Kipps, Thomas J

Volltext

Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism von Hasan, Md Kamrul, Ghia, Emanuela M., Rassenti, Laura Z., Widhopf, George F., Kipps, Thomas J.

Volltext

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody von Zhang, Suping, Zhang, Han, Ghia, Emanuela M., Huang, Jiajia, Wu, Liufeng, Zhang, Jianchao, Lam, Sharon, Lei, Yang, He, Jinsong, Cui, Bing, Widhopf, George F., Yu, Jian, Schwab, Richard, Messer, Karen, Jiang, Wenqi, Parker, Barbara A., Carson, Dennis A., Kipps, Thomas J.

Volltext

Targeting ROR1 Inhibits Epithelial―Mesenchymal Transition and Metastasis von BING CUI, SUPING ZHANG, LIGUANG CHEN, JIANQIANG YU, WIDHOPF, George F, FECTEAU, Jessie-F, RASSENTI, Laura Z, KIPPS, Thomas J

Volltext

Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy von Zhang, Suping, Cui, Bing, Lai, Hsien, Liu, Grace, Ghia, Emanuela M., Widhopf, George F., Zhang, Zhuhong, Wu, Christina C. N., Chen, Liguang, Wu, Rongrong, Schwab, Richard, Carson, Dennis A., Kipps, Thomas J.

Volltext

Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia von Choi, Michael Y., Widhopf, George F., Ghia, Emanuela M., Kidwell, Reilly L., Hasan, Md Kamrul, Yu, Jian, Rassenti, Laura Z., Chen, Liguang, Chen, Yun, Pittman, Emily, Pu, Minya, Messer, Karen, Prussak, Charles E., Castro, Januario E., Jamieson, Catriona, Kipps, Thomas J.

Volltext

A phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic Her2-negative breast cancer von Shatsky, Rebecca A, Batra-Sharma, Hemali, Helsten, Teresa, Schwab, Richard B, Pittman, Emily I, Pu, Minya, Weihe, Elizabeth, Ghia, Emanuela M, Rassenti, Laura Z, Molinolo, Alfredo, Cabrera, Betty, Breitmeyer, James B, Widhopf, 2nd, George F, Messer, Karen, Jamieson, Catriona, Kipps, Thomas J, Parker, Barbara A

Volltext

Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia von Chen, Yun, Chen, Liguang, Yu, Jian, Ghia, Emanuela M., Choi, Michael Y., Zhang, Ling, Zhang, Suping, Sanchez-Lopez, Elsa, Widhopf, George F., Messer, Karen, Rassenti, Laura Z., Jamieson, Catriona, Kipps, Thomas J.

Volltext

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia von Cui, Bing, Ghia, Emanuela M., Chen, Liguang, Rassenti, Laura Z., DeBoever, Christopher, Widhopf, George F., Yu, Jian, Neuberg, Donna S., Wierda, William G., Rai, Kanti R., Kay, Neil E., Brown, Jennifer R., Jones, Jeffrey A., Gribben, John G., Frazer, Kelly A., Kipps, Thomas J.

Volltext

Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells von Hasan, Md Kamrul, Rassenti, Laura, Widhopf, George F., Yu, Jian, Kipps, Thomas J.

Volltext

High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia von Ghia, Emanuela M., Rassenti, Laura Z., Choi, Michael Y., Quijada-Álamo, Miguel, Chu, Elvin, Widhopf, George F., Kipps, Thomas J.

Volltext

Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations von Deniger, Drew C, Yu, Jianqiang, Huls, M Helen, Figliola, Matthew J, Mi, Tiejuan, Maiti, Sourindra N, Widhopf, 2nd, George F, Hurton, Lenka V, Thokala, Radhika, Singh, Harjeet, Olivares, Simon, Champlin, Richard E, Wierda, William G, Kipps, Thomas J, Cooper, Laurence J N

Volltext

Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia von Hasan, Md Kamrul, Yu, Jian, Widhopf, George F., Rassenti, Laura Z., Chen, Liguang, Shen, Zhouxin, Briggs, Steven P., Neuberg, Donna S., Kipps, Thomas J.

Volltext

MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia von Rassenti, Laura Z., Balatti, Veronica, Ghia, Emanuela M., Palamarchuk, Alexey, Tomasello, Luisa, Fadda, Paolo, Pekarsky, Yuri, Widhopf, George F., Kipps, Thomas J., Croce, Carlo M.

Volltext

Dielectrophoretic isolation and detection of cancer-related circulating cell-free DNA biomarkers from blood and plasma von Sonnenberg, Avery, Marciniak, Jennifer Y., Skowronski, Elaine A., Manouchehri, Sareh, Rassenti, Laura, Ghia, Emanuela M., Widhopf II, George F., Kipps, Thomas J., Heller, Michael J.

Volltext

Variant Transcript of ROR1 ENST00000545203 Does Not Encode ROR1 Protein von Xian, Jie, Sinha, Navyaa, Girgis, Christina, Oh, Christopher S, Cring, Matthew R, Widhopf, 2nd, George F, Kipps, Thomas J

Volltext

Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1 von Choi, Michael Y, Widhopf, George F, Wu, Christina C.N, Cui, Bing, Lao, Fitzgerald, Sadarangani, Anil, Cavagnaro, Joy, Prussak, Charles, Carson, Dennis A, Jamieson, Catriona, Kipps, Thomas J

Volltext

Correction: a phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic HER2-negative breast cancer von Shatsky, Rebecca A, Batra-Sharma, Hemali, Helsten, Teresa, Schwab, Richard B, Pittman, Emily I, Pu, Minya, Weihe, Elizabeth, Ghia, Emanuela M, Rassenti, Laura Z, Molinolo, Alfredo, Cabrera, Betty, Breitmeyer, James B, Widhopf Ii, George F, Messer, Karen, Jamieson, Catriona, Kipps, Thomas J, Parker, Barbara A

Volltext

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice von Widhopf, George F., Cuia, Bing, Ghia, Emanuela M., Chen, Liguang, Messer, Karen, Shen, Zhouxin, Briggs, Steven P., Croce, Carlo M., Kipps, Thomas J.

Volltext

IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope von Que, Xuchu, Widhopf, 2nd, George F, Amir, Shahzada, Hartvigsen, Karsten, Hansen, Lotte F, Woelkers, Douglas, Tsimikas, Sotirios, Binder, Christoph J, Kipps, Thomas J, Witztum, Joseph L

Volltext