Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators von Ng, Herman J, Whittemore, Edward R, Tran, Minhtam B, Hogenkamp, Derk J, Broide, Ron S, Johnstone, Timothy B, Zheng, Lijun, Stevens, Karen E, Gee, Kelvin W

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Design, Synthesis, and Activity of a Series of Arylpyrid-3-ylmethanones as Type I Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors von Hogenkamp, Derk J, Ford-Hutchinson, Thomas A, Li, Wen-Yen, Whittemore, Edward R, Yoshimura, Ryan F, Tran, Minhtam B, Johnstone, Timothy B. C, Bascom, Gavin D, Rollins, Hannah, Lu, Lena, Gee, Kelvin W

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Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists von Zhou, Zhang-Lin, Kher, Sunil M, Cai, Sui Xiong, Whittemore, Edward R, Espitia, Stephen A, Hawkinson, Jon E, Tran, Minhtam, Woodward, Richard M, Weber, Eckard, Keana, John F.W

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Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists:  Benzimidazalone and Hydantoin as Phenol Replacements von Schelkun, Robert M, Yuen, Po-wai, Serpa, Kevin, Meltzer, Leonard T, Wise, Lawrence D, Whittemore, Edward R, Woodward, Richard M

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Structure−Activity Relationship of N-(Phenylalkyl)cinnamides as Novel NR2B Subtype-Selective NMDA Receptor Antagonists von Tamiz, Amir P, Cai, Sui Xiong, Zhou, Zhang-Lin, Yuen, Po-Wai, Schelkun, Robert M, Whittemore, Edward R, Weber, Eckard, Woodward, Richard M, Keana, John F. W

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Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition von Johnstone, Timothy B, Gu, Zhenglin, Yoshimura, Ryan F, Villegier, Anne-Sophie, Hogenkamp, Derk J, Whittemore, Edward R, Huang, Jin-Cheng, Tran, Minhtam B, Belluzzi, James D, Yakel, Jerrel L, Gee, Kelvin W

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Enaminone Amides as Novel Orally Active GABAA Receptor Modulators von Hogenkamp, Derk J, Johnstone, Timothy B. C, Huang, Jin-Cheng, Li, Wen-Yen, Tran, Minhtam, Whittemore, Edward R, Bagnera, Rudy E, Gee, Kelvin W

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Structure−Activity Relationships for a Series of Bis(phenylalkyl)amines:  Potent Subtype-Selective Inhibitors of N-Methyl-d-aspartate Receptors von Tamiz, Amir P, Whittemore, Edward R, Zhou, Zhang-Lin, Huang, Jin-Cheng, Drewe, John A, Chen, Jie-Cheng, Cai, Sui-Xiong, Weber, Eckard, Woodward, Richard M, Keana, John F. W

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Subtype-Selective N-Methyl-d-Aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Heteroarylalkynyl)-4-benzylpiperidines von Wright, Jon L, Gregory, Tracy F, Kesten, Suzanne R, Boxer, Peter A, Serpa, Kevin A, Meltzer, Leonard T, Wise, Lawrence D, Espitia, Stephen A, Konkoy, Christopher S, Whittemore, Edward R, Woodward, Richard M

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V102862 (Co 102862): a potent, broad‐spectrum state‐dependent blocker of mammalian voltage‐gated sodium channels von Ilyin, Victor I, Hodges, Dianne D, Whittemore, Edward R, Carter, Richard B, Cai, Sui Xiong, Woodward, Richard M

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Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons von Whittemore, Edward R, Loo, Deryk T, Cotman, Carl W

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Structure−Activity Relationships of 4-Hydroxy-3-nitroquinolin-2(1H)-ones as Novel Antagonists at the Glycine Site of N-Methyl-d-aspartate Receptors von Cai, Sui Xiong, Zhou, Zhang-Lin, Huang, Jin-Cheng, Whittemore, Edward R, Egbuwoku, Zizi O, Hawkinson, Jon E, Woodward, Richard M, Weber, Eckard, Keana, John F. W

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Synthesis of N-Substituted 4-(4-Hydroxyphenyl)piperidines, 4-(4-Hydroxybenzyl)piperidines, and (±)-3-(4-Hydroxyphenyl)pyrrolidines:  Selective Antagonists at the 1a/2B NMDA Recepto... von Guzikowski, Anthony P, Tamiz, Amir P, Acosta-Burruel, Manuel, Hong-Bae, Soo, Cai, Sui Xiong, Hawkinson, Jon E, Keana, John F. W, Kesten, Suzanne R, Shipp, Christina T, Tran, Minhtam, Whittemore, Edward R, Woodward, Richard M, Wright, Jon L, Zhou, Zhang-Lin

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Synthesis and SAR of 5-, 6-, 7- and 8-Aza Analogues of 3-Aryl-4-hydroxyquinolin-2(1 H)-one as NMDA/Glycine Site Antagonists von Zhou, Zhang-Lin, Navratil, James M, Cai, Sui Xiong, Whittemore, Edward R, Espitia, Stephen A, Hawkinson, Jon E, Tran, Minhtam, Woodward, Richard M, Weber, Eckard, Keana, John F.W

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Synthesis and Structure−Activity Relationships of 1,2,3,4-Tetrahydroquinoline-2,3,4-trione 3-Oximes:  Novel and Highly Potent Antagonists for NMDA Receptor Glycine Site von Cai, Sui Xiong, Zhou, Zhang-Lin, Huang, Jin-Cheng, Whittemore, Edward R, Egbuwoku, Zizi O, Lü, Yixin, Hawkinson, Jon E, Woodward, Richard M, Weber, Eckard, Keana, John F. W

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4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine:  A Novel, Potent, and Selective NR1/2B NMDA Receptor Antagonist von Zhou, Zhang-Lin, Cai, Sui Xiong, Whittemore, Edward R, Konkoy, Christopher S, Espitia, Stephen A, Tran, Minhtam, Rock, David M, Coughenour, Linda L, Hawkinson, Jon E, Boxer, Peter A, Bigge, Christopher F, Wise, Lawrence D, Weber, Eckard, Woodward, Richard M, Keana, John F. W

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Enaminone Amides as Novel Orally Active GABA A Receptor Modulators von Hogenkamp, Derk J., Johnstone, Timothy B. C., Huang, Jin-Cheng, Li, Wen-Yen, Tran, Minhtam, Whittemore, Edward R., Bagnera, Rudy E., Gee, Kelvin W.

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Apoptosis is Induced by β-Amyloid in Cultured Central Nervous System Neurons von Loo, Deryk T., Copani, Agata, Pike, Christian J., Whittemore, Edward R., Walencewicz, Andrea J., Cotman, Carl W.

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Synthesis of Racemic 6,7,8,9-Tetrahydro-3-hydroxy-1H-1-benzazepine-2,5-diones as Antagonists of N-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid... von Guzikowski, Anthony P, Whittemore, Edward R, Woodward, Richard M, Weber, Eckard, Keana, John F. W

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Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines von Wright, Jon L, Gregory, Tracy F, Bigge, Christopher F, Boxer, Peter A, Serpa, Kevin, Meltzer, Leonard T, Wise, Lawrence D, Cai, Sui Xiong, Hawkinson, Jon E, Konkoy, Christopher S, Whittemore, Edward R, Woodward, Richard M, Zhou, Zhang-Lin

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