A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA von Sanchez-Contreras, Monica, Sweetwyne, Mariya T, Kohrn, Brendan F, Tsantilas, Kristine A, Hipp, Michael J, Schmidt, Elizabeth K, Fredrickson, Jeanne, Whitson, Jeremy A, Campbell, Matthew D, Rabinovitch, Peter S, Marcinek, David J, Kennedy, Scott R

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The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging von Sanchez-Contreras, Monica, Sweetwyne, Mariya T, Tsantilas, Kristine A, Whitson, Jeremy A, Campbell, Matthew D, Kohrn, Brenden F, Kim, Hyeon Jeong, Hipp, Michael J, Fredrickson, Jeanne, Nguyen, Megan M, Hurley, James B, Marcinek, David J, Rabinovitch, Peter S, Kennedy, Scott R

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Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis von Whitson, Jeremy A, Sell, David R, Goodman, Michael C, Monnier, Vincent M, Fan, Xingjun

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Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption von Valencia, Ana P, Whitson, Jeremy A, Wang, Shari, Nguyen, Leon, den Hartigh, Laura J, Rabinovitch, Peter S, Marcinek, David J

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SS‐31 and NMN: Two paths to improve metabolism and function in aged hearts von Whitson, Jeremy A., Bitto, Alessandro, Zhang, Huiliang, Sweetwyne, Mariya T., Coig, Rene, Bhayana, Saakshi, Shankland, Eric G., Wang, Lu, Bammler, Theo K., Mills, Kathryn F., Imai, Shin‐Ichiro, Conley, Kevin E., Marcinek, David J., Rabinovitch, Peter S.

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Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins von Whitson, Jeremy A., Wilmarth, Phillip A., Klimek, John, Monnier, Vincent M., David, Larry, Fan, Xingjun

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Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis von Whitson, Jeremy A, Zhang, Xiang, Medvedovic, Mario, Chen, Jenny, Wei, Zongbo, Monnier, Vincent M, Fan, Xingjun

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An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice von Tsantilas, Kristine A., Cleghorn, Whitney M., Bisbach, Celia M., Whitson, Jeremy A., Hass, Daniel T., Robbings, Brian M., Sadilek, Martin, Linton, Jonathan D., Rountree, Austin M., Valencia, Ana P., Sweetwyne, Mariya T., Campbell, Matthew D., Zhang, Huiliang, Jankowski, Connor S. R., Sweet, Ian R., Marcinek, David J., Rabinovitch, Peter S., Hurley, James B.

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Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN... von Whitson, Jeremy A., Johnson, Richard, Wang, Lu, Bammler, Theo K., Imai, Shin-Ichiro, Zhang, Huiliang, Fredrickson, Jeanne, Latorre-Esteves, Elena, Bitto, Alessandro, MacCoss, Michael J., Rabinovitch, Peter S.

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Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins von Whitson, Jeremy A., Martín-Pérez, Miguel, Zhang, Tong, Gaffrey, Matthew J., Merrihew, Gennifer E., Huang, Eric, White, Collin C., Kavanagh, Terrance J., Qian, Wei-Jun, Campbell, Matthew D., MacCoss, Michael J., Marcinek, David J., Villén, Judit, Rabinovitch, Peter S.

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Mitochondrial-Driven Inflammation in Aged Kidneys Is Exacerbated by Nicotinamide Mononucleotide but Ameliorated by Elamipretide: FR-PO134 von Saleh, Tara A., Whitson, Jeremy A., Rabinovitch, Peter S., Sweetwyne, Mariya T.

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Long-Term Mitochondrial Protection Reduces Proteinuria in Obese Aged Mice: PO2235 von Sweetwyne, Mariya T., Coig, Rene, Mangalindan, Ruby Sue M., Morton, John, Whitson, Jeremy A., Rabinovitch, Peter S., Ladiges, Warren C.

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Kidney-Specific Landscape of Aging Mitochondrial DNA Mutations by Duplex Sequencing: PO2225 von Sweetwyne, Mariya T., Sanchez-Contreras, Monica Y., Tsantilas, Kristine A., Whitson, Jeremy A., Campbell, Matthew D., Marcinek, David J., Rabinovitch, Peter S., Kennedy, Scott R.

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