The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression von Zhou, Zinan, Rawnsley, David R., Goddard, Lauren M., Pan, Wei, Cao, Xing-Jun, Jakus, Zoltan, Zheng, Hui, Yang, Jisheng, Arthur, J. Simon C., Whitehead, Kevin J., Li, Dean, Zhou, Bin, Garcia, Benjamin A., Zheng, Xiangjian, Kahn, Mark L.

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Endothelial TLR4 and the microbiome drive cerebral cavernous malformations von Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.

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Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature von Chrzanowska-Wodnicka, Magdalena, White, 2nd, Gilbert C, Quilliam, Lawrence A, Whitehead, Kevin J

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The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases von Whitehead, Kevin J, Chan, Aubrey C, Navankasattusas, Sutip, Koh, Wonshill, London, Nyall R, Ling, Jing, Mayo, Anne H, Drakos, Stavros G, Jones, Christopher A, Zhu, Weiquan, Marchuk, Douglas A, Davis, George E, Li, Dean Y

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Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth von Zhu, Yi, Pires, Karla M P, Whitehead, Kevin J, Olsen, Curtis D, Wayment, Benjamin, Zhang, Yi Cheng, Bugger, Heiko, Ilkun, Olesya, Litwin, Sheldon E, Thomas, George, Kozma, Sara C, Abel, E Dale

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Late‐in‐life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts von Cho, Jae Min, Park, Seul‐Ki, Ghosh, Rajeshwary, Ly, Kellsey, Ramous, Caroline, Thompson, Lauren, Hansen, Michele, Mattera, Maria Sara de Lima Coutinho, Pires, Karla Maria, Ferhat, Maroua, Mookherjee, Sohom, Whitehead, Kevin J., Carter, Kandis, Buffolo, Márcio, Boudina, Sihem, Symons, J. David

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Impact of Mechanical Unloading on Microvasculature and Associated Central Remodeling Features of the Failing Human Heart von Drakos, Stavros G., MD, Kfoury, Abdallah G., MD, Hammond, Elizabeth H., MD, Reid, Bruce B., MD, Revelo, Monica P., MD, PhD, Rasmusson, Brad Y., MD, Whitehead, Kevin J., MD, Salama, Mohamed E., MD, Selzman, Craig H., MD, Stehlik, Josef, MD, Clayson, Stephen E., MD, Bristow, Michael R., MD, PhD, Renlund, Dale G., MD, Li, Dean Y., MD, PhD

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Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice von Chan, Aubrey C, Drakos, Stavros G, Ruiz, Oscar E, Smith, Alexandra C H, Gibson, Christopher C, Ling, Jing, Passi, Samuel F, Stratman, Amber N, Sacharidou, Anastasia, Revelo, M Patricia, Grossmann, Allie H, Diakos, Nikolaos A, Davis, George E, Metzstein, Mark M, Whitehead, Kevin J, Li, Dean Y

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An evaluation of the severity and progression of epistaxis in hereditary hemorrhagic telangiectasia 1 versus hereditary hemorrhagic telangiectasia 2 von Hunter, Benjamin N., Timmins, Benjamin H., McDonald, Jamie, Whitehead, Kevin J., Ward, P. Daniel, Wilson, Kevin F.

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The netrin receptor UNC5B promotes angiogenesis in specific vascular beds von Navankasattusas, Sutip, Whitehead, Kevin J, Suli, Arminda, Sorensen, Lise K, Lim, Amy H, Zhao, Jia, Park, Kye Won, Wythe, Joshua D, Thomas, Kirk R, Chien, Chi-Bin, Li, Dean Y

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Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling von Zhou, Zinan, Tang, Alan T., Wong, Weng-Yew, Bamezai, Sharika, Goddard, Lauren M., Shenkar, Robert, Zhou, Su, Yang, Jisheng, Wright, Alexander C., Foley, Matthew, Arthur, J. Simon C., Whitehead, Kevin J., Awad, Issam A., Li, Dean Y., Zheng, Xiangjian, Kahn, Mark L.

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Choroidal melanoma with synchronous Fuchs' adenoma and novel ATRX mutation von Harford, Elli, Palmer, Jane M, Glasson, William J, Warrier, Sunil K, Whitehead, Kevin J, Brooks, Kelly M, Johansson, Peter A, Hayward, Nicholas K, McGrath, Lindsay A

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Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training von Gounder, Sellamuthu S, Kannan, Sankaranarayanan, Devadoss, Dinesh, Miller, Corey J, Whitehead, Kevin J, Whitehead, Kevin S, Odelberg, Shannon J, Firpo, Matthew A, Paine, 3rd, Robert, Hoidal, John R, Abel, E Dale, Rajasekaran, Namakkal S

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Helix-fixed leadless pacemaker implantation through a valve-in-valve tricuspid prosthesis via the femoral approach von Steinberg, Benjamin A., Tandar, Anwar, Whitehead, Kevin J.

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Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4 von Johansson, Peter, Aoude, Lauren G, Wadt, Karin, Glasson, William J, Warrier, Sunil K, Hewitt, Alex W, Kiilgaard, Jens Folke, Heegaard, Steffen, Isaacs, Tim, Franchina, Maria, Ingvar, Christian, Vermeulen, Tersia, Whitehead, Kevin J, Schmidt, Christopher W, Palmer, Jane M, Symmons, Judith, Gerdes, Anne-Marie, Jönsson, Göran, Hayward, Nicholas K

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Investigation of the Genetic Determinants of Telangiectasia and Solid Organ Arteriovenous Malformation Formation in Hereditary Hemorrhagic Telangiectasia (HHT) von Whitehead, Kevin J, Toydemir, Doruk, Wooderchak-Donahue, Whitney, Oakley, Gretchen M, McRae, Bryan, Putnam, Angelica, McDonald, Jamie, Bayrak-Toydemir, Pinar

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Frequency of epistaxis and telangiectasia in patients with hereditary hemorrhagic telangiectasia (HHT) in comparison with the general population: Curaçao diagnostic criteria revisi... von McDonald, Jamie, Kornish, Jenna, Stevenson, David A., Hanson-Kahn, Andrea, Balch, Heather, James, John, Naik, Hetanshi, Whitehead, Kevin J.

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Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation von Gibson, Christopher C, Zhu, Weiquan, Davis, Chadwick T, Bowman-Kirigin, Jay A, Chan, Aubrey C, Ling, Jing, Walker, Ashley E, Goitre, Luca, Delle Monache, Simona, Retta, Saverio Francesco, Shiu, Yan-Ting E, Grossmann, Allie H, Thomas, Kirk R, Donato, Anthony J, Lesniewski, Lisa A, Whitehead, Kevin J, Li, Dean Y

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Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia: A Randomized Clinical Trial von Whitehead, Kevin J, Sautter, Nathan B, McWilliams, Justin P, Chakinala, Murali M, Merlo, Christian A, Johnson, Maribeth H, James, Melissa, Everett, Eric M, Clancy, Marianne S, Faughnan, Marie E, Oh, S. Paul, Olitsky, Scott E, Pyeritz, Reed E, Gossage, James R

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