Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders von Gurney, Mark E, Nugent, Richard A, Mo, Xuesheng, Sindac, Janice A, Hagen, Timothy J, Fox, David, O’Donnell, James M, Zhang, Chong, Xu, Ying, Zhang, Han-Ting, Groppi, Vincent E, Bailie, Marc, White, Ronald E, Romero, Donna L, Vellekoop, A. Samuel, Walker, Joel R, Surman, Matthew D, Zhu, Lei, Campbell, Robert F

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Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers von Cui, Xiaoming, Thomas, Ann, Gerlach, Valerie, White, Ronald E., Morrison, Richard A., Cheng, K.-C.

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Interactions between Penicillin-Binding Proteins (PBPs) and Two Novel Classes of PBP Inhibitors, Arylalkylidene Rhodanines and Arylalkylidene Iminothiazolidin-4-ones von ZERVOSEN, Astrid, LU, Wei-Ping, ZHOULIANG CHEN, WHITE, Ronald E, DEMUTH, Thomas P, FRERE, Jean-Marie

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High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery von White, R E

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Meeting Report: Metabolites in Safety Testing (MIST) Symposium—Safety Assessment of Human Metabolites: What’s REALLY Necessary to Ascertain Exposure Coverage in Safety Tests? von Gao, Hongying, Jacobs, Abigail, White, Ronald E., Booth, Brian P., Obach, R. Scott

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Meeting Report: Metabolites in Safety Testing (MIST) Symposium—Safety Assessment of Human Metabolites: What’s REALLY Necessary to Ascertain Exposure Coverage in Safety Tests? von Gao, Hongying, Jacobs, Abigail, White, Ronald E., Booth, Brian P., Obach, R. Scott

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Whatever happened to cassette-dosing pharmacokinetics? von Manitpisitkul, Prasarn, White, Ronald E.

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Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias von Jackson, Chris M., Blass, Benjamin, Coburn, Keith, Djandjighian, Laurent, Fadayel, Gina, Fluxe, Andrew J., Hodson, Steven J., Janusz, John M., Murawsky, Michael, Ridgeway, James M., White, Ronald E., Wu, Shengde

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A three‐dimensional model of aromatase cytochrome P450 von Graham‐Lorence, Sandra, Peterson, Julian A., Amarneh, Bilal, Simpson, Evan R., White, Ronald E.

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Stereochemical dynamics of aliphatic hydroxylation by cytochrome P-450 von White, Ronald E, Miller, John P, Favreau, Leonard V, Bhattacharyya, Apares

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Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: Correlation study with induction in vivo von Cui, Xiaoming, Thomas, Ann, Han, Yi, Palamanda, Jairam, Montgomery, Diana, White, Ronald E., Morrison, Richard A., Cheng, K.-C.

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Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography–tandem mass spectrometry von Wang, Gangfeng, Hsieh, Yunsheng, Lau, YauYi, Cheng, K.-C, Ng, Kwokei, Korfmacher, Walter A, White, Ronald E

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Development of a high-throughput in vitro assay using a novel Caco-2/rat hepatocyte system for the prediction of oral plasma area under the concentration versus time curve (AUC) in... von Cheng, K.-C., Li, Cheng, Hsieh, Yunsheng, Montgomery, Diana, Liu, Tongtong, White, Ronald E.

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Direct simultaneous analysis of plasma samples for a drug discovery compound and its hydroxyl metabolite using mixed-function column liquid chromatography-tandem mass spectrometry von HSIEH, Yunsheng, BRISSON, Jean-Marc, NG, Kwokei, WHITE, Ronald E, KORFMACHER, Walter A

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Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034 von Cheng, K.-C., Korfmacher, Walter A., White, Ronald E., Njoroge, F. George

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Development of a Screening Assay to Measure the Loss of Antibacterial Activity in the Presence of Proteins: Its Use in Optimizing Compound Structure von Roychoudhury, Siddhartha, Brill, Jessica L., Lu, Wei-Ping, White, Ronald E., Chen, Zhuoliang, Demuth, Thomas P.

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A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction von Cui, Xiaoming, Palamanda, Jairam, Norton, Laura, Thomas, Ann, Lau, Yau Yi, White, Ronald E., Cheng, K.-C.

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Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spec... von Kim, Hong, Feng, Wenqing, Chan, Tze-Ming, Rindgen, Diane, Bryant, Matthew, Cox, Kathleen A., Xia, Yan, Reichard, Gregory, Paliwal, Sunil, Hesk, David, Palamanda, Jairam, White, Ronald E., Nomeir, Amin A.

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X-ray Diffraction Analysis of Cytochrome P450 2B4 Reconstituted into Liposomes von Miller, John P, Herbette, Leo G, White, Ronald E

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Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new che... von Korfmacher, Walter A., Cox, Kathleen A., Ng, Kwokei J., Veals, John, Hsieh, Yunsheng, Wainhaus, Sam, Broske, Lisa, Prelusky, Dan, Nomeir, Amin, White, Ronald E.

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