Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans von List, James F., Whaley, Jean M.

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Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats von SONGPING HAN, HAGAN, Deborah L, TAYLOR, Joseph R, LI XIN, WEI MENG, BILLER, Scott A, WETTERAU, John R, WASHBURN, William N, WHALEY, Jean M

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Carcinogenicity Risk Assessment Supports the Chronic Safety of Dapagliflozin, an Inhibitor of Sodium–Glucose Co-Transporter 2, in the Treatment of Type 2 Diabetes Mellitus von Reilly, Timothy P., Graziano, Michael J., Janovitz, Evan B., Dorr, Thomas E., Fairchild, Craig, Lee, Francis, Chen, Jian, Wong, Tai, Whaley, Jean M., Tirmenstein, Mark

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Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody von Hinke, Simon A., Cieniewicz, Anne M., Kirchner, Thomas, D'Aquino, Katharine, Nanjunda, Rupesh, Aligo, Jason, Perkinson, Robert, Cooper, Philip, Boayke, Ken, Chiu, Mark L., Jarantow, Steve, Lacy, Eilyn R., Liang, Yin, Johnson, Dana L., Whaley, Jean M., Lingham, Russell B., Kihm, Anthony J.

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Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members von Chen, Jian, Williams, Sandy, Ho, Samantha, Loraine, Howard, Hagan, Deborah, Whaley, Jean M., Feder, John N.

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SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function von JURCZAK, Michael J, LEE, Hui-Young, SHULMAN, Gerald I, KIBBEY, Richard G, BIRKENFELD, Andreas L, JORNAYVAZ, Francois R, FREDERICK, David W, PONGRATZ, Rebecca L, XIAOXIAN ZHAO, MOECKEL, Gilbert W, SAMUEL, Varman T, WHALEY, Jean M

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Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes von Meng, Wei, Ellsworth, Bruce A, Nirschl, Alexandra A, McCann, Peggy J, Patel, Manorama, Girotra, Ravindar N, Wu, Gang, Sher, Philip M, Morrison, Eamonn P, Biller, Scott A, Zahler, Robert, Deshpande, Prashant P, Pullockaran, Annie, Hagan, Deborah L, Morgan, Nathan, Taylor, Joseph R, Obermeier, Mary T, Humphreys, William G, Khanna, Ashish, Discenza, Lorell, Robertson, James G, Wang, Aiying, Han, Songping, Wetterau, John R, Janovitz, Evan B, Flint, Oliver P, Whaley, Jean M, Washburn, William N

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Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders von Moore, Fang, Wang, Wei, Zhao, Guohua, Mignone, James, Meng, Wei, Chu, Ching-Hsuen, Ma, Zhengping, Azzara, Anthony, Cullen, Mary Jane, Pelleymounter, Mary Ann, Appiah, Kingsley, Cvijic, Mary Ellen, Dierks, Elizabeth, Chang, Shu, Foster, Kimberly, Kopcho, Lisa, O'Malley, Kevin, Li, Yi-Xin, Khandelwal, Purnima, Whaley, Jean M., Mathur, Arvind, Hou, Xiaoping, Wu, Dauh-Rurng, Robl, Jeffrey A., Cheng, Dong, Devasthale, Pratik

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Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders von Turdi, Huji, Chao, Hannguang, Hangeland, Jon J, Ahmad, Saleem, Meng, Wei, Brigance, Robert, Zhao, Guohua, Wang, Wei, Moore, Fang, Ye, Xiang-Yang, Mathur, Arvind, Hou, Xiaoping, Kempson, James, Wu, Dauh-Rurng, Li, Yi-Xin, Azzara, Anthony V, Ma, Zhengping, Chu, Ching-Hsuen, Chen, Luping, Cullen, Mary Jane, Rooney, Suzanne, Harvey, Susan, Kopcho, Lisa, Panemangelor, Reshma, Abell, Lynn, O’Malley, Kevin, Keim, William J, Dierks, Elizabeth, Chang, Shu, Foster, Kimberly, Apedo, Atsu, Harden, David, Dabros, Marta, Gao, Qi, Pelleymounter, Mary Ann, Whaley, Jean M, Robl, Jeffrey A, Cheng, Dong, Lawrence, R. Michael, Devasthale, Pratik

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Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities von Jurica, Elizabeth A., Wu, Ximao, Williams, Kristin N., Haque, Lauren E., Rampulla, Richard A., Mathur, Arvind, Zhou, Min, Cao, Gary, Cai, Hong, Wang, Tao, Liu, Heng, Xu, Carrie, Kunselman, Lori K., Antrilli, Thomas M., Hicks, Michael B., Sun, Qin, Dierks, Elizabeth A., Apedo, Atsu, Moore, Douglas B., Foster, Kimberly A., Cvijic, Mary Ellen, Panemangalore, Reshma, Khandelwal, Purnima, Wilkes, Jason J., Zinker, Bradley A., Robertson, Donald G., Janovitz, Evan B., Galella, Michael, Li, Yi-Xin, Li, Julia, Ramar, Thangeswaran, Jalagam, Prasada Rao, Jayaram, Ramya, Whaley, Jean M., Barrish, Joel C., Robl, Jeffrey A., Ewing, William R., Ellsworth, Bruce A.

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Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists von Shi, Jun, Gu, Zhengxiang, Jurica, Elizabeth Anne, Wu, Ximao, Haque, Lauren E, Williams, Kristin N, Hernandez, Andres S, Hong, Zhenqiu, Gao, Qi, Dabros, Marta, Davulcu, Akin H, Mathur, Arvind, Rampulla, Richard A, Gupta, Arun Kumar, Jayaram, Ramya, Apedo, Atsu, Moore, Douglas B, Liu, Heng, Kunselman, Lori K, Brady, Edward J, Wilkes, Jason J, Zinker, Bradley A, Cai, Hong, Shu, Yue-Zhong, Sun, Qin, Dierks, Elizabeth A, Foster, Kimberly A, Xu, Carrie, Wang, Tao, Panemangalore, Reshma, Cvijic, Mary Ellen, Xie, Chunshan, Cao, Gary G, Zhou, Min, Krupinski, John, Whaley, Jean M, Robl, Jeffrey A, Ewing, William R, Ellsworth, Bruce Alan

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Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode von Jurica, Elizabeth A, Wu, Ximao, Williams, Kristin N, Hernandez, Andres S, Nirschl, David S, Rampulla, Richard A, Mathur, Arvind, Zhou, Min, Cao, Gary, Xie, Chunshan, Jacob, Biji, Cai, Hong, Wang, Tao, Murphy, Brian J, Liu, Heng, Xu, Carrie, Kunselman, Lori K, Hicks, Michael B, Sun, Qin, Schnur, Dora M, Sitkoff, Doree F, Dierks, Elizabeth A, Apedo, Atsu, Moore, Douglas B, Foster, Kimberly A, Cvijic, Mary Ellen, Panemangalore, Reshma, Flynn, Neil A, Maxwell, Brad D, Hong, Yang, Tian, Yuan, Wilkes, Jason J, Zinker, Bradley A, Whaley, Jean M, Barrish, Joel C, Robl, Jeffrey A, Ewing, William R, Ellsworth, Bruce A

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Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance von Cieniewicz, Anne M, Kirchner, Thomas, Hinke, Simon A, Nanjunda, Rupesh, D'Aquino, Katharine, Boayke, Ken, Cooper, Philip R, Perkinson, Robert, Chiu, Mark L, Jarantow, Stephen, Johnson, Dana L, Whaley, Jean M, Lacy, Eilyn R, Lingham, Russell B, Liang, Yin, Kihm, Anthony J

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SGLT2 knockout prevents hyperglycemia and is associated with reduced pancreatic β-cell death in genetically obese mice von Jurczak, Michael J., Saini, Saumya, Ioja, Simona, Costa, Diana K., Udeh, Nnamdi, Zhao, Xiaojian, Whaley, Jean M., Kibbey, Richard G.

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Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus von Whaley, Jean M, Tirmenstein, Mark, Reilly, Timothy P, Poucher, Simon M, Saye, Joanne, Parikh, Shamik, List, James F

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Eleven Amino Acid Glucagon-like Peptide-1 Receptor Agonists with Antidiabetic Activity von Mapelli, Claudio, Natarajan, Sesha I, Meyer, Jean-Philippe, Bastos, Margarita M, Bernatowicz, Michael S, Lee, Ving G, Pluscec, Jelka, Riexinger, Douglas J, Sieber-McMaster, Ellen S, Constantine, Keith L, Smith-Monroy, Constance A, Golla, Rajasree, Ma, Zhengping, Longhi, Daniel A, Shi, Dan, Xin, Li, Taylor, Joseph R, Koplowitz, Barry, Chi, Cecilia L, Khanna, Ashish, Robinson, Gordon W, Seethala, Ramakrishna, Antal-Zimanyi, Ildiko A, Stoffel, Robert H, Han, Songping, Whaley, Jean M, Huang, Christine S, Krupinski, John, Ewing, William R

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Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin, a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor von Tirmenstein, Mark, Dorr, Thomas E., Janovitz, Evan B., Hagan, Deborah, Abell, Lynn M., Onorato, Joelle M., Whaley, Jean M., Graziano, Michael J., Reilly, Timothy P.

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Comparative Study of p53 Gene and Protein Alterations in Human Astrocytic Tumors von Louis, David N, Deimling, Andreas Von, Chung, Richard Y, Rubio, Mari-Paz, Whaley, Jean M, Eibl, Robert H, Ohgaki, Hiroko, Wiestler, Otmar D, Thor, Ann D, Seizinger, Bernd R

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Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2 von Ellsworth, Bruce A., Meng, Wei, Patel, Manorama, Girotra, Ravindar N., Wu, Gang, Sher, Philip M., Hagan, Deborah L., Obermeier, Mary T., Humphreys, William G., Robertson, James G., Wang, Aiying, Han, Songping, Waldron, Thomas L., Morgan, Nathan N., Whaley, Jean M., Washburn, William N.

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Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity von BLANKENSHIP, C, NAGLICH, J. G, WHALEY, J. M, SEIZINGER, B, KLEY, N

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