Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits von Wong, Pancras C., Crain, Earl J., Bozarth, Jeffrey M., Wu, Yiming, Dilger, Andrew K., Wexler, Ruth R., Ewing, William R., Gordon, David, Luettgen, Joseph M.

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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy von Dilger, Andrew K, Pabbisetty, Kumar B, Corte, James R, De Lucca, Indawati, Fang, Tianan, Yang, Wu, Pinto, Donald J. P, Wang, Yufeng, Zhu, Yeheng, Mathur, Arvind, Li, Jianqing, Hou, Xiaoping, Smith, Daniel, Sun, Dawn, Zhang, Huiping, Krishnananthan, Subramaniam, Wu, Dauh-Rurng, Myers, Joseph E, Sheriff, Steven, Rossi, Karen A, Chacko, Silvi, Zheng, Joanna J, Galella, Michael A, Ziemba, Theresa, Dierks, Elizabeth A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl, Wong, Pancras C, Luettgen, Joseph M, Wexler, Ruth R, Ewing, William R

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Factor XIa Inhibitors as New Anticoagulants von Quan, Mimi L, Pinto, Donald J. P, Smallheer, Joanne M, Ewing, William R, Rossi, Karen A, Luettgen, Joseph M, Seiffert, Dietmar A, Wexler, Ruth R

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Factor Xa Inhibitors: Next-Generation Antithrombotic Agents von Pinto, Donald J. P, Smallheer, Joanne M, Cheney, Daniel L, Knabb, Robert M, Wexler, Ruth R

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From basic science to life-saving therapy: the rationale, and drug discovery efforts that led to the direct factor Xa inhibitor eliquis von Knabb, Robert M., Wexler, Ruth R.

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Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors von Hu, Zilun, Sitkoff, Doree, Glunz, Peter W., Zou, Yan, Wang, Cailan, Muckelbauer, Jodi K., Adam, Leonard P., Wexler, Ruth R., Quan, Mimi L.

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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selec... von Pinto, Donald J. P, Orwat, Michael J, Koch, Stephanie, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela, Wong, Pancras C, Rendina, Alan R, Luettgen, Joseph M, Knabb, Robert M, He, Kan, Xin, Baomin, Wexler, Ruth R, Lam, Patrick Y. S

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Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212) von Pinto, Donald J. P., Orwat, Michael J., Smith, Leon M., Quan, Mimi L., Lam, Patrick Y. S., Rossi, Karen A., Apedo, Atsu, Bozarth, Jeffrey M., Wu, Yiming, Zheng, Joanna J., Xin, Baomin, Toussaint, Nathalie, Stetsko, Paul, Gudmundsson, Olafur, Maxwell, Brad, Crain, Earl J., Wong, Pancras C., Lou, Zhen, Harper, Timothy W., Chacko, Silvi A., Myers, Joseph E., Sheriff, Steven, Zhang, Huiping, Hou, Xiaoping, Mathur, Arvind, Seiffert, Dietmar A., Wexler, Ruth R., Luettgen, Joseph M., Ewing, William R.

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Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure von Meng, Wei, Pi, Zulan, Brigance, Robert, Rossi, Karen A, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Luk, Chiuwa E, Generaux, Claudia N, Wang, Tao, Wexler, Ruth R, Finlay, Heather J

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Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4 von Priestley, E. Scott, Banville, Jacques, Deon, Daniel, Dubé, Laurence, Gagnon, Marc, Guy, Julia, Lapointe, Philippe, Lavallée, Jean-François, Martel, Alain, Plamondon, Serge, Rémillard, Roger, Ruediger, Edward, Tremblay, François, Posy, Shana L., Guarino, Victor R., Richter, Jeremy M., Li, Jianqing, Gupta, Anuradha, Vetrichelvan, Muthalagu, Balapragalathan, T. J., Mathur, Arvind, Hua, Ji, Callejo, Mario, Guay, Jocelyne, Sum, Chi Shing, Cvijic, Mary Ellen, Watson, Carol, Wong, Pancras, Yang, Jing, Bouvier, Michel, Gordon, David A., Wexler, Ruth R., Marinier, Anne

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Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure von Richter, Jeremy M., Gunaga, Prashantha, Yadav, Navnath, Bora, Rajesh Onkardas, Bhide, Rajeev, Rajugowda, Nagendra, Govindrajulu, Kavitha, Godesi, Sreenivasulu, Akuthota, Nagarjuna, Rao, Prasanna, Sivaraman, Aneesh, Panda, Manoranjan, Kaspady, Mahammed, Gupta, Anuradha, Mathur, Arvind, Levesque, Paul C., Gulia, Jyoti, Dokania, Manoj, Ramarao, Manjunath, Kole, Prashant, Chacko, Silvi, Lentz, Kimberley A., Sivaprasad LVJ, Sankara, Thatipamula, Rajendra Prasad, Sridhar, Srikanth, Kamble, Shyam, Govindrajan, Arun, Soleman, Sharif I., Gordon, David A., Wexler, Ruth R., Priestley, E. Scott

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Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors von Hu, Zilun, Wang, Cailan, Sitkoff, Doree, Cheadle, Nathan L., Xu, Songmei, Muckelbauer, Jodi K., Adam, Leonard P., Wexler, Ruth R., Quan, Mimi L.

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Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis von Zhang, Xiaojun, Jiang, Wen, Richter, Jeremy M., Bates, J. Alex, Reznik, Samuel K., Stachura, Sylwia, Rampulla, Richard, Doddalingappa, Dyamanna, Ulaganathan, Sankar, Hua, Ji, Bostwick, Jeffrey S., Sum, Chi, Posy, Shana, Malmstrom, Sarah, Dickey, Joyce, Harden, David, Lawrence, R. Michael, Guarino, Victor R., Schumacher, William A., Wong, Pancras, Yang, Jing, Gordon, David A., Wexler, Ruth R., Priestley, E. Scott

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In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure von Gargalovic, Peter, Wong, Pancras, Onorato, Joelle, Finlay, Heather, Wang, Tao, Yan, Mujing, Crain, Earl, St-Onge, Stéphane, Héroux, Madeleine, Bouvier, Michel, Xu, Carrie, Chen, Xue-Qing, Generaux, Claudia, Lawrence, Michael, Wexler, Ruth, Gordon, David

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Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists von Tora, George, Jiang, Ji, Bostwick, Jeffrey S., Gargalovic, Peter S., Onorato, Joelle M., Luk, Chiuwa E., Generaux, Claudia, Xu, Carrie, Galella, Michael A., Wang, Tao, He, Yan, Wexler, Ruth R., Finlay, Heather J.

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Design and preparation of N-linked hydroxypyridine-based APJ agonists von Richter, Jeremy M., Alex Bates, J., Gargalovic, Peter, Onorato, Joelle M., Generaux, Claudia, Wang, Tao, Gordon, David A., Wexler, Ruth R., Finlay, Heather J.

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Empowering Voices: Inspiring Women in Medicinal Chemistry von Blanco, Maria-Jesus, Bronson, Joanne J., DiMauro, Erin F., Dzierba, Carolyn, Eggen, MariJean, Garner, Amanda L., Georg, Gunda, Giarolla, Jeanine, Goodwin, Nicole C., Grenier-Davies, Melissa C., Haskell-Luevano, Carrie, Holzgrabe, Ulrike, Huang, Rong, Lagiakos, H. Rachel, Leftheris, Katerina, Martin, Yvonne, Matos, Maria João, May-Dracka, Tricia L., Müller, Christa E., Newman, Amy H., Parmee, Emma, Petter, Jennifer C., Tamayo, Nuria A., Wexler, Ruth R., Bolognesi, Maria Laura, Ripka, Amy, Young, Wendy

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Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO) von Hu, Carol H., Neissel Valente, Meriah W., Halpern, O. Scott, Jusuf, Sutjano, Khan, Javed A., Locke, Gregory A., Duke, Gerald J., Liu, Xiaoqin, Duclos, Franck J., Wexler, Ruth R., Kick, Ellen K., Smallheer, Joanne M.

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Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate von Johnson, James A, Kim, Soong-Hoon, Jiang, Ji, Phillips, Monique, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Luk, Chiuwa E, Generaux, Claudia, He, Yan, Chen, Xue-Qing, Xu, Carrie, Galella, Michael A, Wang, Tao, Gordon, David A, Wexler, Ruth R, Finlay, Heather J

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Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase von Shaw, Scott A., Vokits, Benjamin P., Dilger, Andrew K., Viet, Andrew, Clark, Charles G., Abell, Lynn M., Locke, Gregory A., Duke, Gerald, Kopcho, Lisa M., Dongre, Ashok, Gao, Ji, Krishnakumar, Arathi, Jusuf, Sutjano, Khan, Javed, Spronk, Steven A., Basso, Michael D., Zhao, Lei, Cantor, Glenn H., Onorato, Joelle M., Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.

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