Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening von Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, Gerwen, Bastiaan van, van der Ven, Marieke, Wetering, Marc van de, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J

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The intestinal stem cell von Barker, Nick, van de Wetering, Marc, Clevers, Hans

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Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion von van Es, Johan H., Wiebrands, Kay, López-Iglesias, Carmen, van de Wetering, Marc, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Sasaki, Nobuo, Peters, Peter J., van Oudenaarden, Alexander, Clevers, Hans

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Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium von Stange, Daniel E., Koo, Bon-Kyoung, Huch, Meritxell, Sibbel, Greg, Basak, Onur, Lyubimova, Anna, Kujala, Pekka, Bartfeld, Sina, Koster, Jan, Geahlen, Jessica H., Peters, Peter J., van Es, Johan H., van de Wetering, Marc, Mills, Jason C., Clevers, Hans

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Lineage Tracing Reveals Lgr5+Stem Cell Activity in Mouse Intestinal Adenomas von Schepers, Arnout G., Snippert, Hugo J., Stange, Daniel E., van den Born, Maaike, van Es, Johan H., van de Wetering, Marc, Clevers, Hans

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ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response von Heijmans, Jarom, van Lidth de Jeude, Jooske F, Koo, Bon-Kyoung, Rosekrans, Sanne L, Wielenga, Mattheus C B, van de Wetering, Marc, Ferrante, Marc, Lee, Amy S, Onderwater, Jos J M, Paton, James C, Paton, Adrienne W, Mommaas, A Mieke, Kodach, Liudmila L, Hardwick, James C, Hommes, Daniël W, Clevers, Hans, Muncan, Vanesa, van den Brink, Gijs R

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Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients von van de Wetering, Marc, Francies, Hayley E., Francis, Joshua M., Bounova, Gergana, Iorio, Francesco, Pronk, Apollo, van Houdt, Winan, van Gorp, Joost, Taylor-Weiner, Amaro, Kester, Lennart, McLaren-Douglas, Anne, Blokker, Joyce, Jaksani, Sridevi, Bartfeld, Sina, Volckman, Richard, van Sluis, Peter, Li, Vivian S.W., Seepo, Sara, Sekhar Pedamallu, Chandra, Cibulskis, Kristian, Carter, Scott L., McKenna, Aaron, Lawrence, Michael S., Lichtenstein, Lee, Stewart, Chip, Koster, Jan, Versteeg, Rogier, van Oudenaarden, Alexander, Saez-Rodriguez, Julio, Vries, Robert G.J., Getz, Gad, Wessels, Lodewyk, Stratton, Michael R., McDermott, Ultan, Meyerson, Matthew, Garnett, Mathew J., Clevers, Hans

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Origins of lymphatic and distant metastases in human colorectal cancer von Naxerova, Kamila, Reiter, Johannes G., Brachtel, Elena, Lennerz, Jochen K., van de Wetering, Marc, Rowan, Andrew, Cai, Tianxi, Clevers, Hans, Swanton, Charles, Nowak, Martin A., Elledge, Stephen J., Jain, Rakesh K.

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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver von Huch, Meritxell, Gehart, Helmuth, van Boxtel, Ruben, Hamer, Karien, Blokzijl, Francis, Verstegen, Monique M.A., Ellis, Ewa, van Wenum, Martien, Fuchs, Sabine A., de Ligt, Joep, van de Wetering, Marc, Sasaki, Nobuo, Boers, Susanne J., Kemperman, Hans, de Jonge, Jeroen, Ijzermans, Jan N.M., Nieuwenhuis, Edward E.S., Hoekstra, Ruurdtje, Strom, Stephen, Vries, Robert R.G., van der Laan, Luc J.W., Cuppen, Edwin, Clevers, Hans

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts von Sato, Toshiro, van Es, Johan H., Snippert, Hugo J., Stange, Daniel E., Vries, Robert G., van den Born, Maaike, Barker, Nick, Shroyer, Noah F., van de Wetering, Marc, Clevers, Hans

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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration von Huch, Meritxell, Dorrell, Craig, Boj, Sylvia F., van Es, Johan H., Li, Vivian S. W., van de Wetering, Marc, Sato, Toshiro, Hamer, Karien, Sasaki, Nobuo, Finegold, Milton J., Haft, Annelise, Vries, Robert G., Grompe, Markus, Clevers, Hans

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Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases von Weeber, Fleur, van de Wetering, Marc, Hoogstraat, Marlous, Dijkstra, Krijn K., Krijgsman, Oscar, Kuilman, Thomas, Gadellaa-van Hooijdonk, Christa G. M., van der Velden, Daphne L., Peeper, Daniel S., Cuppen, Edwin P. J. G., Vries, Robert G., Clevers, Hans, Voest, Emile E.

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Dll1+ secretory progenitor cells revert to stem cells upon crypt damage von van Es, Johan H., Sato, Toshiro, van de Wetering, Marc, Lyubimova, Anna, Yee Nee, Annie Ng, Gregorieff, Alex, Sasaki, Nobuo, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Martens, Anton C. M., Barker, Nick, van Oudenaarden, Alexander, Clevers, Hans

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Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis von Huch, Meritxell, Bonfanti, Paola, Boj, Sylvia F, Sato, Toshiro, Loomans, Cindy J M, van de Wetering, Marc, Sojoodi, Mozhdeh, Li, Vivian S W, Schuijers, Jurian, Gracanin, Ana, Ringnalda, Femke, Begthel, Harry, Hamer, Karien, Mulder, Joyce, van Es, Johan H, de Koning, Eelco, Vries, Robert G J, Heimberg, Harry, Clevers, Hans

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Crypt stem cells as the cells-of-origin of intestinal cancer von Barker, Nick, Ridgway, Rachel A., van Es, Johan H., van de Wetering, Marc, Begthel, Harry, van den Born, Maaike, Danenberg, Esther, Clarke, Alan R., Sansom, Owen J., Clevers, Hans

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Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids von Bolhaqueiro, Ana C. F., Ponsioen, Bas, Bakker, Bjorn, Klaasen, Sjoerd J., Kucukkose, Emre, van Jaarsveld, Richard H., Vivié, Judith, Verlaan-Klink, Ingrid, Hami, Nizar, Spierings, Diana C. J., Sasaki, Nobuo, Dutta, Devanjali, Boj, Sylvia F., Vries, Robert G. J., Lansdorp, Peter M., van de Wetering, Marc, van Oudenaarden, Alexander, Clevers, Hans, Kranenburg, Onno, Foijer, Floris, Snippert, Hugo J. G., Kops, Geert J. P. L.

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Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate von van der Flier, Laurens G., van Gijn, Marielle E., Hatzis, Pantelis, Kujala, Pekka, Haegebarth, Andrea, Stange, Daniel E., Begthel, Harry, van den Born, Maaike, Guryev, Victor, Oving, Irma, van Es, Johan H., Barker, Nick, Peters, Peter J., van de Wetering, Marc, Clevers, Hans

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The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers von Muñoz, Javier, Stange, Daniel E, Schepers, Arnout G, van de Wetering, Marc, Koo, Bon-Kyoung, Itzkovitz, Shalev, Volckmann, Richard, Kung, Kevin S, Koster, Jan, Radulescu, Sorina, Myant, Kevin, Versteeg, Rogier, Sansom, Owen J, van Es, Johan H, Barker, Nick, van Oudenaarden, Alexander, Mohammed, Shabaz, Heck, Albert J R, Clevers, Hans

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Single-cell dissection of transcriptional heterogeneity in human colon tumors von Dalerba, Piero, Kalisky, Tomer, Sahoo, Debashis, Rajendran, Pradeep S, Rothenberg, Michael E, Leyrat, Anne A, Sim, Sopheak, Okamoto, Jennifer, Johnston, Darius M, Qian, Dalong, Zabala, Maider, Bueno, Janet, Neff, Norma F, Wang, Jianbin, Shelton, Andrew A, Visser, Brendan, Hisamori, Shigeo, Shimono, Yohei, van de Wetering, Marc, Clevers, Hans, Clarke, Michael F, Quake, Stephen R

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Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids von Kluiver, Thomas A., Lu, Yuyan, Schubert, Stephanie A., Kraaier, Lianne J., Ringnalda, Femke, Lijnzaad, Philip, DeMartino, Jeff, Megchelenbrink, Wouter L., Amo-Addae, Vicky, Eising, Selma, de Faria, Flavia W., Münter, Daniel, van de Wetering, Marc, Kerl, Kornelius, Duiker, Evelien, van den Heuvel, Marius C., de Meijer, Vincent E., de Kleine, Ruben H., Molenaar, Jan J., Margaritis, Thanasis, Stunnenberg, Hendrik G., de Krijger, Ronald R., Zsiros, József, Clevers, Hans, Peng, Weng Chuan

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