Acetylation site specificities of lysine deacetylase inhibitors in human cells von Schölz, Christian, Weinert, Brian T, Wagner, Sebastian A, Beli, Petra, Miyake, Yasuyuki, Qi, Jun, Jensen, Lars J, Streicher, Werner, McCarthy, Anna R, Westwood, Nicholas J, Lain, Sonia, Cox, Jürgen, Matthias, Patrick, Mann, Matthias, Bradner, James E, Choudhary, Chunaram

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Targeting of the MYCN protein with small molecule c-MYC inhibitors von Müller, Inga, Larsson, Karin, Frenzel, Anna, Oliynyk, Ganna, Zirath, Hanna, Prochownik, Edward V, Westwood, Nicholas J, Henriksson, Marie Arsenian

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Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator von Lain, Sonia, Hollick, Jonathan J., Campbell, Johanna, Staples, Oliver D., Higgins, Maureen, Aoubala, Mustapha, McCarthy, Anna, Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Mathers, Joanne, Holland, Stephen J., Stark, Michael J.R., Pass, Georgia, Woods, Julie, Lane, David P., Westwood, Nicholas J.

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Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor von Straight, Aaron F., Cheung, Amy, Limouze, John, Chen, Irene, Westwood, Nick J., Sellers, James R., Mitchison, Timothy J.

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A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage von Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia

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Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity von Medda, Federico, Russell, Rupert J. M, Higgins, Maureen, McCarthy, Anna R, Campbell, Johanna, Slawin, Alexandra M. Z, Lane, David P, Lain, Sonia, Westwood, Nicholas J

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A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods von Yarrow, Justin C, Perlman, Zachary E, Westwood, Nicholas J, Mitchison, Timothy J

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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage von Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Fernández, Andrés Pastor, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia

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Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib von Ladds, Marcus J G W, Pastor-Fernández, Andrés, Popova, Gergana, van Leeuwen, Ingeborg M M, Eng, Kai Er, Drummond, Catherine J, Johansson, Lars, Svensson, Richard, Westwood, Nicholas J, McCarthy, Anna R, Tholander, Fredrik, Popa, Mihaela, Lane, David P, McCormack, Emmet, McInerney, Gerald M, Bhatia, Ravi, Laín, Sonia

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Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner von McCarthy, Anna R, Sachweh, Marijke C C, Higgins, Maureen, Campbell, Johanna, Drummond, Catherine J, van Leeuwen, Ingeborg M M, Pirrie, Lisa, Ladds, Marcus J G W, Westwood, Nicholas J, Laín, Sonia

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Use of Biomimetic Diversity-Oriented Synthesis to Discover Galanthamine-Like Molecules with Biological Properties beyond Those of the Natural Product von Pelish, Henry E, Westwood, Nicholas J, Feng, Yan, Kirchhausen, Tomas, Shair, Matthew D

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A Small-Molecule Approach to Studying Invasive Mechanisms of Toxoplasma gondii von Carey, Kimberly L., Westwood, Nicholas J., Mitchison, Timothy J., Ward, Gary E., Miller, Louis H.

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Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins von McCarthy, Anna R., Pirrie, Lisa, Hollick, Jonathan J., Ronseaux, Sebastien, Campbell, Johanna, Higgins, Maureen, Staples, Oliver D., Tran, Fanny, Slawin, Alexandra M.Z., Lain, Sonia, Westwood, Nicholas J.

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Mechanism-specific signatures for small-molecule p53 activators von van Leeuwen, Ingeborg M.M., Higgins, Maureen, Campbell, Johanna, Brown, Christopher J., McCarthy, Anna R., Pirrie, Lisa, Westwood, Nicholas J., Laín, Sonia

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Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6 von MacCallum, Stephanie F., Groves, Michael J., James, John, Murray, Karen, Appleyard, Virginia, Prescott, Alan R., Drbal, Abed A., Nicolaou, Anna, Cunningham, Joan, Haydock, Sally, Ganley, Ian G., Westwood, Nicholas J., Coates, Philip J., Lain, Sonia, Tauro, Sudhir

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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage von Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia

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The discovery of nongenotoxic activators of p53: Building on a cell-based high-throughput screen von McCarthy, Anna R, Hollick, Jonathan J, Westwood, Nicholas J

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Pilot screening programme for small molecule activators of p53 von Berkson, Rachel G., Hollick, Jonathan J., Westwood, Nicholas J., Woods, Julie A., Lane, David P., Lain, Sonia

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Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity von Pirrie, Lisa, McCarthy, Anna R, Major, Louise L, Morkūnaitė, Vaida, Zubrienė, Asta, Matulis, Daumantas, Lain, Sonia, Lebl, Tomas, Westwood, Nicholas J

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Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a 1 H-NMR Method to Assess Deacetylase Activity von Pirrie, L, McCarthy, AR, Major, LL, Morkunaite, V, Zubriene, A, Matulis, D, Lain, S, Lebl, T, Westwood, NJ

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