Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition von Taipale, Mikko, Krykbaeva, Irina, Koeva, Martina, Kayatekin, Can, Westover, Kenneth D., Karras, Georgios I., Lindquist, Susan

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations von Hunter, John C, Manandhar, Anuj, Carrasco, Martin A, Gurbani, Deepak, Gondi, Sudershan, Westover, Kenneth D

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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS von Ambrogio, Chiara, Köhler, Jens, Zhou, Zhi-Wei, Wang, Haiyun, Paranal, Raymond, Li, Jiaqi, Capelletti, Marzia, Caffarra, Cristina, Li, Shuai, Lv, Qi, Gondi, Sudershan, Hunter, John C., Lu, Jia, Chiarle, Roberto, Santamaría, David, Westover, Kenneth D., Jänne, Pasi A.

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Neutrophil–Lymphocyte and Platelet–Lymphocyte Ratios as Prognostic Factors after Stereotactic Radiation Therapy for Early-Stage Non–Small-Cell Lung Cancer von Cannon, Nathan A., Meyer, Jeffrey, Iyengar, Puneeth, Ahn, Chul, Westover, Kenneth D., Choy, Hak, Timmerman, Robert

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate von Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

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In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C von Hunter, John C., Gurbania, Deepak, Ficarro, Scott B., Carrasco, Martin A., Lim, Sang Min, Choi, Hwan Geun, Xie, Ting, Marto, Jarrod A., Chen, Zhe, Gray, Nathanael S., Westover, Kenneth D.

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Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor von Lim, Sang Min, Westover, Kenneth D., Ficarro, Scott B., Harrison, Rane A., Choi, Hwan Geun, Pacold, Michael E., Carrasco, Martin, Hunter, John, Kim, Nam Doo, Xie, Ting, Sim, Taebo, Jänne, Pasi A., Meyerson, Matthew, Marto, Jarrod A., Engen, John R., Gray, Nathanael S.

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Case Report: Resolution of radiation pneumonitis with androgens and growth hormone von Yen, Allen, Westover, Kenneth D.

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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C von Zeng, Mei, Lu, Jia, Li, Lianbo, Feru, Frederic, Quan, Chunshan, Gero, Thomas W., Ficarro, Scott B., Xiong, Yuan, Ambrogio, Chiara, Paranal, Raymond M., Catalano, Marco, Shao, Jay, Wong, Kwok-Kin, Marto, Jarrod A., Fischer, Eric S., Jänne, Pasi A., Scott, David A., Westover, Kenneth D., Gray, Nathanael S.

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Shell feature: a new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer von Hao, Hongxia, Zhou, Zhiguo, Li, Shulong, Maquilan, Genevieve, Folkert, Michael R, Iyengar, Puneeth, Westover, Kenneth D, Albuquerque, Kevin, Liu, Fang, Choy, Hak, Timmerman, Robert, Yang, Lin, Wang, Jing

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Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis von Wang, Dong, Bushnell, David A., Westover, Kenneth D., Kaplan, Craig D., Kornberg, Roger D.

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Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution von Wang, Dong, Bushnell, David A, Huang, Xuhui, Westover, Kenneth D, Levitt, Michael, Kornberg, Roger D

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Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling von Hwang, So-Young, Deng, Xianming, Byun, Sanguine, Lee, Chan, Lee, Seung-Joo, Suh, Hyunsuk, Zhang, Jianming, Kang, Qiaofeng, Zhang, Ting, Westover, Kenneth D., Mandinova, Anna, Lee, Sam W.

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GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing von Yu, Dong-Min, Zhao, Jiawei, Lee, Eunice E, Kim, Dohun, Mahapatra, Ruchika, Rose, Elysha K, Zhou, Zhiwei, Hosler, Calvin, El Kurdi, Abdullah, Choe, Jun-Yong, Abel, E Dale, Hoxhaj, Gerta, Westover, Kenneth D, Cho, Raymond J, Cheng, Jeffrey B, Wang, Richard C

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Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR von QINGSONG LIU, CHUNXIAO XU, ERCAN, Dalia, NIEPEL, Mario, THOREEN, Carson C, KANG, Seong A, PATRICELLI, Matthew P, YUCHUAN WANG, TUPPER, Tanya, ALTABEF, Abigail, KAWAMURA, Hidemasa, HELD, Kathryn D, KIRUBAKARAN, Sivapriya, CHOU, Danny M, ELLEDGE, Stephen J, JANNE, Pasi A, WONG, Kwok-Kin, SABATINI, David M, GRAY, Nathanael S, XIN ZHANG, HUR, Wooyoung, YAN LIU, KWIATKOWSKI, Nicholas P, JINHUA WANG, WESTOVER, Kenneth D, PENG GAO

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Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability von Kopra, Kari, Valtonen, Salla, Mahran, Randa, Kapp, Jonas N, Hassan, Nazia, Gillette, William, Dennis, Bryce, Li, Lianbo, Westover, Kenneth D, Plückthun, Andreas, Härmä, Harri

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Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT von Li, Qing, Zhou, Zhi-Wei, Duan, Wei, Qian, Cheng-Yuan, Wang, Shu-Nan, Deng, Meng-Sheng, Zi, Dan, Wang, Jian-Min, Mao, Cheng-Yi, Song, Guanbin, Wang, Dong, Westover, Kenneth D., Xu, Cheng-Xiong

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The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51 von Park, Jung Mi, Yang, Seung Wook, Zhuang, Wei, Bera, Asim K., Liu, Yan, Gurbani, Deepak, von Hoyningen-Huene, Sergei J., Sakurada, Sadie Miki, Gan, Haiyun, Pruett-Miller, Shondra M., Westover, Kenneth D., Potts, Malia B.

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ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis von Ramirez, Nora-Guadalupe P., Lee, Jeon, Zheng, Yue, Li, Lianbo, Dennis, Bryce, Chen, Didi, Challa, Ashwini, Planelles, Vicente, Westover, Kenneth D., Alto, Neal M., D’Orso, Iván

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The to and fro of Rho von Westover, Kenneth D.

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