Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors von Westover, D, Zugazagoitia, J, Cho, B C, Lovly, C M, Paz-Ares, L

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Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition von Taipale, Mikko, Krykbaeva, Irina, Koeva, Martina, Kayatekin, Can, Westover, Kenneth D., Karras, Georgios I., Lindquist, Susan

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations von Hunter, John C, Manandhar, Anuj, Carrasco, Martin A, Gurbani, Deepak, Gondi, Sudershan, Westover, Kenneth D

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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS von Ambrogio, Chiara, Köhler, Jens, Zhou, Zhi-Wei, Wang, Haiyun, Paranal, Raymond, Li, Jiaqi, Capelletti, Marzia, Caffarra, Cristina, Li, Shuai, Lv, Qi, Gondi, Sudershan, Hunter, John C., Lu, Jia, Chiarle, Roberto, Santamaría, David, Westover, Kenneth D., Jänne, Pasi A.

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Neutrophil–Lymphocyte and Platelet–Lymphocyte Ratios as Prognostic Factors after Stereotactic Radiation Therapy for Early-Stage Non–Small-Cell Lung Cancer von Cannon, Nathan A., Meyer, Jeffrey, Iyengar, Puneeth, Ahn, Chul, Westover, Kenneth D., Choy, Hak, Timmerman, Robert

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate von Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

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Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype von Olson, Calla M., Liang, Yanke, Leggett, Alan, Park, Woojun D., Li, Lianbo, Mills, Caitlin E., Elsarrag, Selma Z., Ficarro, Scott B., Zhang, Tinghu, Düster, Robert, Geyer, Matthias, Sim, Taebo, Marto, Jarrod A., Sorger, Peter K., Westover, Ken D., Lin, Charles Y., Kwiatkowski, Nicholas, Gray, Nathanael S.

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In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C von Hunter, John C., Gurbania, Deepak, Ficarro, Scott B., Carrasco, Martin A., Lim, Sang Min, Choi, Hwan Geun, Xie, Ting, Marto, Jarrod A., Chen, Zhe, Gray, Nathanael S., Westover, Kenneth D.

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Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis von Wang, Dong, Bushnell, David A., Westover, Kenneth D., Kaplan, Craig D., Kornberg, Roger D.

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Case Report: Resolution of radiation pneumonitis with androgens and growth hormone von Yen, Allen, Westover, Kenneth D.

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Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor von Lim, Sang Min, Westover, Kenneth D., Ficarro, Scott B., Harrison, Rane A., Choi, Hwan Geun, Pacold, Michael E., Carrasco, Martin, Hunter, John, Kim, Nam Doo, Xie, Ting, Sim, Taebo, Jänne, Pasi A., Meyerson, Matthew, Marto, Jarrod A., Engen, John R., Gray, Nathanael S.

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Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution von Wang, Dong, Bushnell, David A, Huang, Xuhui, Westover, Kenneth D, Levitt, Michael, Kornberg, Roger D

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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C von Zeng, Mei, Lu, Jia, Li, Lianbo, Feru, Frederic, Quan, Chunshan, Gero, Thomas W., Ficarro, Scott B., Xiong, Yuan, Ambrogio, Chiara, Paranal, Raymond M., Catalano, Marco, Shao, Jay, Wong, Kwok-Kin, Marto, Jarrod A., Fischer, Eric S., Jänne, Pasi A., Scott, David A., Westover, Kenneth D., Gray, Nathanael S.

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Shell feature: a new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer von Hao, Hongxia, Zhou, Zhiguo, Li, Shulong, Maquilan, Genevieve, Folkert, Michael R, Iyengar, Puneeth, Westover, Kenneth D, Albuquerque, Kevin, Liu, Fang, Choy, Hak, Timmerman, Robert, Yang, Lin, Wang, Jing

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Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms von Bushnell, David A., Westover, Kenneth D., Davis, Ralph E., Kornberg, Roger D.

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Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR von QINGSONG LIU, CHUNXIAO XU, ERCAN, Dalia, NIEPEL, Mario, THOREEN, Carson C, KANG, Seong A, PATRICELLI, Matthew P, YUCHUAN WANG, TUPPER, Tanya, ALTABEF, Abigail, KAWAMURA, Hidemasa, HELD, Kathryn D, KIRUBAKARAN, Sivapriya, CHOU, Danny M, ELLEDGE, Stephen J, JANNE, Pasi A, WONG, Kwok-Kin, SABATINI, David M, GRAY, Nathanael S, XIN ZHANG, HUR, Wooyoung, YAN LIU, KWIATKOWSKI, Nicholas P, JINHUA WANG, WESTOVER, Kenneth D, PENG GAO

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Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling von Hwang, So-Young, Deng, Xianming, Byun, Sanguine, Lee, Chan, Lee, Seung-Joo, Suh, Hyunsuk, Zhang, Jianming, Kang, Qiaofeng, Zhang, Ting, Westover, Kenneth D., Mandinova, Anna, Lee, Sam W.

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GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing von Yu, Dong-Min, Zhao, Jiawei, Lee, Eunice E, Kim, Dohun, Mahapatra, Ruchika, Rose, Elysha K, Zhou, Zhiwei, Hosler, Calvin, El Kurdi, Abdullah, Choe, Jun-Yong, Abel, E Dale, Hoxhaj, Gerta, Westover, Kenneth D, Cho, Raymond J, Cheng, Jeffrey B, Wang, Richard C

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Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability von Kopra, Kari, Valtonen, Salla, Mahran, Randa, Kapp, Jonas N, Hassan, Nazia, Gillette, William, Dennis, Bryce, Li, Lianbo, Westover, Kenneth D, Plückthun, Andreas, Härmä, Harri

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Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II von Westover, Kenneth D., Bushnell, David A., Kornberg, Roger D.

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