Targeting microglia for the treatment of Alzheimer's Disease von Wes, Paul D., Sayed, Faten A., Bard, Frédérique, Gan, Li

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Transcriptomic analysis of purified human cortical microglia reveals age-associated changes von Galatro, Thais F, Holtman, Inge R, Lerario, Antonio M, Vainchtein, Ilia D, Brouwer, Nieske, Sola, Paula R, Veras, Mariana M, Pereira, Tulio F, Leite, Renata E P, Möller, Thomas, Wes, Paul D, Sogayar, Mari C, Laman, Jon D, den Dunnen, Wilfred, Pasqualucci, Carlos A, Oba-Shinjo, Sueli M, Boddeke, Erik W G M, Marie, Suely K N, Eggen, Bart J L

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Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease von Wes, Paul D., Holtman, Inge R., Boddeke, Erik W.G.M., Möller, Thomas, Eggen, Bart J.L.

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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis von Holtman, Inge R, Raj, Divya D, Miller, Jeremy A, Schaafsma, Wandert, Yin, Zhuoran, Brouwer, Nieske, Wes, Paul D, Möller, Thomas, Orre, Marie, Kamphuis, Willem, Hol, Elly M, Boddeke, Erik W G M, Eggen, Bart J L

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Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor von Möller, Thomas, Bard, Frédérique, Bhattacharya, Anindya, Biber, Knut, Campbell, Brian, Dale, Elena, Eder, Claudia, Gan, Li, Garden, Gwenn A., Hughes, Zoë A., Pearse, Damien D., Staal, Roland G. W., Sayed, Faten A., Wes, Paul D., Boddeke, Hendrikus W. G. M.

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Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease von Wes, Paul D, Easton, Amy, Corradi, John, Barten, Donna M, Devidze, Nino, DeCarr, Lynn B, Truong, Amy, He, Aiqing, Barrezueta, Nestor X, Polson, Craig, Bourin, Clotilde, Flynn, Marianne E, Keenan, Stefanie, Lidge, Regina, Meredith, Jere, Natale, Joanne, Sankaranarayanan, Sethu, Cadelina, Greg W, Albright, Charlie F, Cacace, Angela M

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Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease von Whitworth, A.J, Theodore, D.A, Greene, J.C, Benes, H, Wes, P.D, Pallanck, L.J

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Type I interferon regulation by USP18 is a key vulnerability in cancer von Jové, Veronica, Wheeler, Heather, Lee, Chiachin Wilson, Healy, David R., Levine, Kymberly, Ralph, Erik C., Yamaguchi, Masaya, Jiang, Ziyue Karen, Cabral, Edward, Xu, Yingrong, Stock, Jeffrey, Yang, Bing, Giddabasappa, Anand, Loria, Paula, Casimiro-Garcia, Agustin, Kessler, Benedikt M., Pinto-Fernández, Adán, Frattini, Véronique, Wes, Paul D., Wang, Feng

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Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model von Kitazawa, Masashi, Cheng, David, Tsukamoto, Michelle R, Koike, Maya A, Wes, Paul D, Vasilevko, Vitaly, Cribbs, David H, LaFerla, Frank M

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Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease von Trinh, Kien, Moore, Katherine, Wes, Paul D, Muchowski, Paul J, Dey, Joyoti, Andrews, Laurie, Pallanck, Leo J

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Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease von Meulener, Marc, Whitworth, Alexander J., Armstrong-Gold, Cecilia E., Rizzu, Patrizia, Heutink, Peter, Wes, Paul D., Pallanck, Leo J., Bonini, Nancy M.

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Subchronic treatment with aldosterone induces depression-like behaviours and gene expression changes relevant to major depressive disorder von Hlavacova, Natasa, Wes, Paul D., Ondrejcakova, Maria, Flynn, Marianne E., Poundstone, Patricia K., Babic, Stanislav, Murck, Harald, Jezova, Daniela

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C. elegans odour discrimination requires asymmetric diversity in olfactory neurons von Bargmann, Cornelia I, Wes, Paul D

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Drosophila models pioneer a new approach to drug discovery for Parkinson's disease von Whitworth, Alexander J., Wes, Paul D., Pallanck, Leo J.

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TRPC1, a Human Homolog of a Drosophila Store-Operated Channel von Wes, Paul D., Chevesich, Jorge, Jeromin, Andreas, Rosenberg, Carla, Stetten, Gail, Montell, Craig

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Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD von Montell, Craig, Wes, Paul D, Xu, Xian-Zhong Shawn, Li, Hong-Sheng, Chien, Fred, Doberstein, Stephen K

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Retinal Targets for Calmodulin Include Proteins Implicated in Synaptic Transmission von Xu, Xian-Zhong Shawn, Wes, Paul D., Chen, Hua, Li, Hong-Sheng, Yu, Mujun, Morgan, Stewart, Liu, Yuru, Montell, Craig

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Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development von Harrison, Susan M.W., Rudolph, Jennifer L., Spencer, Michael L., Wes, Paul D., Montell, Craig, Andres, Douglas A., Harrison, Douglas A.

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Blocking Interleukin-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal β-Catenin Pathway Function in an Alzheimer's Disease Model von Kitazawa, Masashi, Cheng, David, Tsukamoto, Michelle, Koike, Maya, Wes, Paul D., Vasilevko, Vitaly, Cribbs, David H., LaFerla, Frank M.

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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis von Holtman, Inge R, Raj, Divya D, Miller, Jeremy A, Schaafsma, Wandert, Yin, Zhuoran, Brouwer, Nieske, Wes, Paul D, Möller, Thomas, Orre, Marie, Kamphuis, Willem, Hol, EM, Boddeke, Erik W G M, Eggen, Bart J L

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