The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma von Miess, Heike, Dankworth, Beatrice, Gouw, Arvin M., Rosenfeldt, Mathias, Schmitz, Werner, Jiang, Ming, Saunders, Becky, Howell, Michael, Downward, Julian, Felsher, Dean W., Peck, Barrie, Schulze, Almut

Volltext

Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming von Wu, Hao, Zhao, Xiufeng, Hochrein, Sophia M., Eckstein, Miriam, Gubert, Gabriela F., Knöpper, Konrad, Mansilla, Ana Maria, Öner, Arman, Doucet-Ladevèze, Remi, Schmitz, Werner, Ghesquière, Bart, Theurich, Sebastian, Dudek, Jan, Gasteiger, Georg, Zernecke, Alma, Kobold, Sebastian, Kastenmüller, Wolfgang, Vaeth, Martin

Volltext

Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress von Kaymak, Irem, Maier, Carina R, Schmitz, Werner, Campbell, Andrew D, Dankworth, Beatrice, Ade, Carsten P, Walz, Susanne, Paauwe, Madelon, Kalogirou, Charis, Marouf, Hecham, Rosenfeldt, Mathias T, Gay, David M, McGregor, Grace H, Sansom, Owen J, Schulze, Almut

Volltext

The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2 von Kreß, Julia Katharina Charlotte, Jessen, Christina, Hufnagel, Anita, Schmitz, Werner, Xavier da Silva, Thamara Nishida, Ferreira dos Santos, Ancély, Mosteo, Laura, Goding, Colin R., Friedmann Angeli, José Pedro, Meierjohann, Svenja

Volltext

The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression von Jessen, Christina, Kreß, Julia K. C., Baluapuri, Apoorva, Hufnagel, Anita, Schmitz, Werner, Kneitz, Susanne, Roth, Sabine, Marquardt, André, Appenzeller, Silke, Ade, Carsten P., Glutsch, Valerie, Wobser, Marion, Friedmann-Angeli, José Pedro, Mosteo, Laura, Goding, Colin R., Schilling, Bastian, Geissinger, Eva, Wolf, Elmar, Meierjohann, Svenja

Volltext

Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries von Bohnert, Simone, Reinert, Christoph, Trella, Stefanie, Cattaneo, Andrea, Preiß, Ulrich, Bohnert, Michael, Zwirner, Johann, Büttner, Andreas, Schmitz, Werner, Ondruschka, Benjamin

Volltext

An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration von Rahman, M. Tanvir, Koski, M. Kristian, Panecka-Hofman, Joanna, Schmitz, Werner, Kastaniotis, Alexander J., Wade, Rebecca C., Wierenga, Rik K., Hiltunen, J. Kalervo, Autio, Kaija J.

Volltext

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma von Alborzinia, Hamed, Chen, Zhiyi, Yildiz, Umut, Freitas, Florencio Porto, Vogel, Felix C E, Varga, Julianna Patricia, Batani, Jasmin, Bartenhagen, Christoph, Schmitz, Werner, Büchel, Gabriele, Michalke, Bernhard, Zheng, Jashuo, Meierjohann, Svenja, Girardi, Enrico, Espinet, Elisa, Flórez, Andrés F, dos Santos, Ancely Ferreira, Aroua, Nesrine, Cheytan, Tasneem, Haenlin, Julie, Schlicker, Lisa, Xavier da Silva, Thamara N, Przybylla, Adriana, Zeisberger, Petra, Superti‐Furga, Giulio, Eilers, Martin, Conrad, Marcus, Fabiano, Marietta, Schweizer, Ulrich, Fischer, Matthias, Schulze, Almut, Trumpp, Andreas, Friedmann Angeli, José Pedro

Volltext

Receptor oligomerization and beyond: a case study in bone morphogenetic proteins von Heinecke, Kai, Seher, Axel, Schmitz, Werner, Mueller, Thomas D, Sebald, Walter, Nickel, Joachim

Volltext

c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis von Vollmuth, Nadine, Schlicker, Lisa, Guo, Yongxia, Hovhannisyan, Pargev, Janaki-Raman, Sudha, Kurmasheva, Naziia, Schmitz, Werner, Schulze, Almut, Stelzner, Kathrin, Rajeeve, Karthika, Rudel, Thomas

Volltext

Mass Spectrometric Metabolic Fingerprinting of 2-Deoxy-D-Glucose (2-DG)-Induced Inhibition of Glycolysis and Comparative Analysis of Methionine Restriction versus Glucose Restricti... von Volland, Julian Manuel, Kaupp, Johannes, Schmitz, Werner, Wünsch, Anna Chiara, Balint, Julia, Möllmann, Marc, El-Mesery, Mohamed, Frackmann, Kyra, Peter, Leslie, Hartmann, Stefan, Kübler, Alexander Christian, Seher, Axel

Volltext

Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase von Peter, Stefanie, Bultinck, Jennyfer, Myant, Kevin, Jaenicke, Laura A, Walz, Susanne, Müller, Judith, Gmachl, Michael, Treu, Matthias, Boehmelt, Guido, Ade, Carsten P, Schmitz, Werner, Wiegering, Armin, Otto, Christoph, Popov, Nikita, Sansom, Owen, Kraut, Norbert, Eilers, Martin

Volltext

Glycolytic flux control by drugging phosphoglycolate phosphatase von Jeanclos, Elisabeth, Schlötzer, Jan, Hadamek, Kerstin, Yuan-Chen, Natalia, Alwahsh, Mohammad, Hollmann, Robert, Fratz, Stefanie, Yesilyurt-Gerhards, Dilan, Frankenbach, Tina, Engelmann, Daria, Keller, Angelika, Kaestner, Alexandra, Schmitz, Werner, Neuenschwander, Martin, Hergenröder, Roland, Sotriffer, Christoph, von Kries, Jens Peter, Schindelin, Hermann, Gohla, Antje

Volltext

Platelet‐derived lipids promote insulin secretion of pancreatic β cells von Karwen, Till, Kolczynska‐Matysiak, Katarzyna, Gross, Carina, Löffler, Mona C, Friedrich, Mike, Loza‐Valdes, Angel, Schmitz, Werner, Wit, Magdalena, Dziaczkowski, Filip, Belykh, Andrei, Trujillo‐Viera, Jonathan, El‐Merahbi, Rabih, Deppermann, Carsten, Nawaz, Sameena, Hastoy, Benoit, Demczuk, Agnieszka, Erk, Manuela, Wieckowski, Mariusz R, Rorsman, Patrik, Heinze, Katrin G, Stegner, David, Nieswandt, Bernhard, Sumara, Grzegorz

Volltext

The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry von Kiema, Tiila-Riikka, Thapa, Chandan J, Laitaoja, Mikko, Schmitz, Werner, Maksimainen, Mirko M, Fukao, Toshiyuki, Rouvinen, Juha, Jänis, Janne, Wierenga, Rik K

Volltext

Structural enzymology studies with the substrate 3S‐hydroxybutanoyl‐CoA: bifunctional MFE1 is a less efficient dehydrogenase than monofunctional HAD von Sridhar, Shruthi, Kiema, Tiila‐Riikka, Schmitz, Werner, Widersten, Mikael, Wierenga, Rik K.

Volltext

Cysteine Restriction in Murine L929 Fibroblasts as an Alternative Strategy to Methionine Restriction in Cancer Therapy von Schmitz, Werner, Ries, Elena, Koderer, Corinna, Völter, Maximilian Friedrich, Wünsch, Anna Chiara, El-Mesery, Mohamed, Frackmann, Kyra, Kübler, Alexander Christian, Linz, Christian, Seher, Axel

Volltext

Metabolic Fingerprinting of Murine L929 Fibroblasts as a Cell-Based Tumour Suppressor Model System for Methionine Restriction von Schmitz, Werner, Koderer, Corinna, El-Mesery, Mohamed, Gubik, Sebastian, Sampers, Rene, Straub, Anton, Kübler, Alexander Christian, Seher, Axel

Volltext

Thiol starvation triggers melanoma state switching in an ATF4 and NRF2-dependent manner von Meinert, Madlen, Jessen, Christina, Hufnagel, Anita, Kreß, Julia Katharina Charlotte, Burnworth, Mychal, Däubler, Theo, Gallasch, Till, Xavier da Silva, Thamara Nishida, dos Santos, Ancély Ferreira, Ade, Carsten Patrick, Schmitz, Werner, Kneitz, Susanne, Friedmann Angeli, José Pedro, Meierjohann, Svenja

Volltext

GDF-5 can act as a context-dependent BMP-2 antagonist von Klammert, Uwe, Mueller, Thomas D, Hellmann, Tina V, Wuerzler, Kristian K, Kotzsch, Alexander, Schliermann, Anna, Schmitz, Werner, Kuebler, Alexander C, Sebald, Walter, Nickel, Joachim

Volltext