CRISPR/Cas9 Genome Editing of Human-Induced Pluripotent Stem Cells Followed by Granulocytic Differentiation von Dannenmann, Benjamin, Nasri, Masoud, Welte, Karl, Skokowa, Julia

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P458: HIPSC DISEASE MODELING TO STUDY LEUKEMIA DEVELOPMENT IN HAX1 VS ELANE ASSOCIATED CONGENITAL NEUTROPENIA von Dannenmann, Benjamin, Klimiankou, Maksim, Zeidler, Cornelia, Welte, Karl, Skokowa, Julia

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Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1 von Skokowa, Julia, Fobiwe, John Paul, Dan, Lan, Thakur, Basant Kumar, Welte, Karl

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Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition von Skupio, Urszula, Welte, Julia, Serrat, Roman, Eraso-Pichot, Abel, Julio-Kalajzić, Francisca, Gisquet, Doriane, Cannich, Astrid, Delcasso, Sebastien, Matias, Isabelle, Fundazuri, Unai B., Pouvreau, Sandrine, Pagano Zottola, Antonio C., Lavanco, Gianluca, Drago, Filippo, Ruiz de Azua, Inigo, Lutz, Beat, Bellocchio, Luigi, Busquets-Garcia, Arnau, Chaouloff, Francis, Marsicano, Giovanni

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Differential Expression of C/Ebpa and Its Stem Cell-Specific Targets in Congenital Neutropenias and Cyclic Neutropenias von Zeidler, Alexander, Borbaran-Bravo, Natalia, Koenig, Josef, Zeidler, Cornelia, Skokowa, Julia, Welte, Karl

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A Zebrafish Model for Severe Congenital Neutropenia with Jagn1b-Deficiency von Doll, Larissa, Aghaallaei, Narges, Skokowa, Julia, Welte, Karl, Bajoghli, Baubak

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Hax1 Is Indispensable for Neutrophil Development in Zebrafish von Doll, Larissa, Aghaallaei, Narges, Welte, Karl, Skokowa, Julia, Bajoghli, Baubak

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ELANE mutant–specific activation of different UPR pathways in congenital neutropenia von Nustede, Rainer, Klimiankou, Maksim, Klimenkova, Olga, Kuznetsova, Inna, Zeidler, Cornelia, Welte, Karl, Skokowa, Julia

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Transcriptome Analysis of Severe Congenital Neutropenia Associated Leukemia with Different Types of RUNX1 Mutations in an iPSC-Based Model von Dannenmann, Benjamin, Oswald, Benedikt, Ritter, Malte U, Nasri, Masoud, Bernhard, Regine, Zeidler, Cornelia, Welte, Karl, Skokowa, Julia, Klimiankou, Maksim

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A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation von Doll, Larissa, Welte, Karl, Skokowa, Julia, Bajoghli, Baubak

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Role of TPO in the Differentiation of Embryonic Stem Cells into Hematopoetic Cells von Wang, Zheng, Andri, Pramono, Julia, Skokowa, Karl, Welte

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HAX1 Associated Congenital Neutropenia: A 25 Year Long-Term Analysis of the European Scnir Cohort von Zeidler, Cornelia, Mellor-Heineke, Sabine, Klimiankou, Maksim, Skokowa, Julia, Welte, Karl

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Structural Insights into the Methane-Generating Enzyme from a Methoxydotrophic Methanogen Reveal a Restrained Gallery of Post-Translational Modifications von Kurth, Julia Maria, Müller, Marie-Caroline, Welte, Cornelia Ulrike, Wagner, Tristan

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First Case of Leukemia in a Child Suffering from Cyclic Neutropenia with ELANE Mutation von Zeidler, Cornelia, Mellor-Heineke, Sabine, Klimiankou, Maksim, Skokowa, Julia, Welte, Karl

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Dysregulation of Myeloid‐specific Transcription Factors in Congenital Neutropenia: Rescue by NAMPT/NAD + /SIRT1 von Skokowa, Julia, Welte, Karl

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Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia von Klimiankou, Maksim, Mellor-Heineke, Sabine, Zeidler, Cornelia, Welte, Karl, Skokowa, Julia

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Differential Expression of Neutrophil Granule Protein Genes in Bone Marrow Myeloid Cells at the Peak and Nadir of Neutrophil Counts in Cyclic Neutropenia von Klimenkova, Olga, Klimiankou, Maksim, Kanz, Lothar, Zeidler, Cornelia, Welte, Karl, Skokowa, Julia

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Homozygous Mutations in PHRF1 and PPARG in a Patient with Congenital Neutropenia and Profound Monocytosis: Understanding the Pathway Beyond Monocyte Versus Granulocyte Cell-Fate Ch... von Loghmani-khouzani, Houra, Klimiankou, Maksim, Kandabarau, Siarhei, Zeidler, Cornelia, Welte, Karl, Skokowa, Julia

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Time Course of Acquisition of a CSF3R Mutation and Subsequent Development of AML in a Patient with Cyclic Neutropenia von Klimiankou, Maksim, Klimenkova, Olga, Kanz, Lothar, Zeidler, Cornelia, Welte, Karl, Skokowa, Julia

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Anaerobic methanotrophic archaea of the ANME-2d clade feature lipid composition that differs from other ANME archaea von Kurth, Julia M, Smit, Nadine T, Berger, Stefanie, Schouten, Stefan, Jetten, Mike S.M, Welte, Cornelia U

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