Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals von Dunetz, Joshua R, Magano, Javier, Weisenburger, Gerald A

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Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19 von Allais, Christophe, Bernhardson, David, Brown, Adam R., Chinigo, Gary M., Desrosiers, Jean-Nicolas, DiRico, Kenneth J., Hotham, Ian, Jones, Brian P., Kulkarni, Samir A., Lewis, Chad A., Lira, Ricardo, Loach, Richard P., Morse, Peter D., Mousseau, James J., Perry, Matthew A., Peng, Zhihui, Place, David W., Rane, Anil M., Samp, Lacey, Singer, Robert A., Wang, Zheng, Weisenburger, Gerald A., Yayla, Hatice G., Zanghi, Joseph M.

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Streamlined Synthesis of a Bicyclic Amine Moiety Using an Enzymatic Amidation and Identification of a Novel Solid Form von Brown, Maria S, Caporello, Michaella A, Goetz, Adam E, Johnson, Amber M, Jones, Kris N, Knopf, Kevin M, Kulkarni, Samir A, Lee, Taegyo, Li, Bryan, Lu, Cuong V, Magano, Javier, Puchlopek-Dermenci, Angela L. A, Reyes, Giselle P, Ruggeri, Sally Gut, Wei, Lulin, Weisenburger, Gerald A, Wisdom, Richard A, Zhang, Mengtan

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Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors von Li, Bryan, Barnhart, Richard W, Dion, Amelie, Guinness, Steven, Happe, Alan, Hayward, Cheryl M, Kohrt, Jeffrey, Makowski, Teresa, Maloney, Mark, Nelson, Jade D, Nematalla, Asaad, McWilliams, J. Christopher, Peng, Zhihui, Raggon, Jeffrey, Sagal, John, Weisenburger, Gerald A, Bao, Denghui, Gonzalez, Miguel, Lu, Jiangping, McLaws, Mark D, Tao, Jian, Wu, Baolin

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Enabled Process To Synthesize Monobactam 1 for Early Development von Tao, Yong, Lall, Manjinder S, Boyles, David C, Lilley, Susan C, Pattavina, Sebastian D, Rafka, Robert J, Sitter, Barbara J, Stewart, Andrew Morgan, Szeliga, Jan, Weisenburger, Gerald A

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Dynamic Thermodynamic Resolution:  Control of Enantioselectivity through Diastereomeric Equilibration von Beak, Peter, Anderson, David R, Curtis, Michael D, Laumer, Jason M, Pippel, Daniel J, Weisenburger, Gerald A

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Development of the Commercial Route for the Manufacture of a 5‑Lipoxygenase Inhibitor PF-04191834 von Chekal, Brian, Damon, David, LaFrance, Danny, Leeman, Kyle, Mojica, Carlos, Palm, Andrew, St. Pierre, Michael, Sieser, Janice, Sutherland, Karen, Vaidyanathan, Rajappa, Van Alsten, John, Vanderplas, Brian, Wager, Carrie, Weisenburger, Gerald, Withbroe, Gregory, Yu, Shu

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Kinetics and Mechanism of the (−)-Sparteine-Mediated Deprotonation of (E)-N-Boc-N-(p-methoxyphenyl)-3-cyclohexylallylamine von Pippel, Daniel J, Weisenburger, Gerald A, Faibish, Neil C, Beak, Peter

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Practical Considerations and Examples in Adapting Amidations to Continuous Flow Processing in Early Development von Li, Bryan, Weisenburger, Gerald A., McWilliams, J. Christopher

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α-Lithiation of N-(tert-Butoxycarbonyl)-N-(p- methoxyphenyl)allylamines Mediated by (−)-Sparteine:  Enantioselective Syntheses of Either Enantiomer of 3-Substituted Enecarbamates... von Weisenburger, Gerald A, Beak, Peter

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Measurement of Gas Flow Rates from Small-Scale Reactions von Weisenburger, Gerald A, Barnhart, Richard W, Steeno, Gregory S

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Safety Notables: Information from the Literature von Weisenburger, Gerald A, Vogt, Paul F

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Temperature- and Electrophile-Dependent Stereocontrol:  A Structural and Mechanistic Investigation of (−)-Sparteine-Mediated Asymmetric Lithiation−Substitution Sequences of N-Boc-N... von Weisenburger, Gerald A, Faibish, Neil C, Pippel, Daniel J, Beak, Peter

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Ligand Control and Asymmetric Michael Reactions of Enantioenriched Configurationally Stable N-Boc Anilino Benzylic and Allylic Organolithium Species von Park, Yong Sun, Weisenburger, Gerald A, Beak, Peter

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A comparative study of amide-bond forming reagents in aqueous media – Substrate scope and reagent compatibility von Badland, Matthew, Crook, Robert, Delayre, Bastien, Fussell, Steven J., Gladwell, Iain, Hawksworth, Michael, Howard, Roger M., Walton, Robert, Weisenburger, Gerald A.

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Safety Notables: Information from the Literature von Weisenburger, Gerald A, Vogt, Paul F

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SPECIAL FEATURE SECTION:  SAFETY OF CHEMICAL PROCESSES Safety HighlightsSafety Notables:  Information from the Literature von Weisenburger, Gerald A, Vogt, Paul F

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Determination of Reaction Heat: A Comparison of Measurement and Estimation Techniques von Weisenburger, Gerald A, Barnhart, Richard W, Clark, Jerry D, Dale, David J, Hawksworth, Mike, Higginson, Paul D, Kang, Ying, Knoechel, Donald J, Moon, Brian S, Shaw, Stephen M, Taber, Geraldine P, Tickner, Derek L

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Synthesis of Nirmatrelvir: Design and Optimization of an Efficient Telescoped Amidation–Dehydration Sequence von Algera, Russell F., Baldwin, Aaron F., Bowles, Paul, Clarke, Hugh J., Connor, Christina G., Cordi, Eric M., Do, Nga M., Nicholson, Lindsay D., Georgian, William, Happe, Alan, Herman, Madeline I., Hilou, Elaa, James, Chintelle, Johnson, Amber M., Kalinowski, Maciej, Kulkarni, Samir A., Launer-Felty, Katherine D., Lee, Johnny W., Lee, Taegyo, Lopez, Jorge, McInturff, Emma L., Piper, Jared L., Place, David W., Ragan, John A., Rauschenberger, Blake, Ryder, Katherine, Stanley, Michael, Weisenburger, Gerald A., Weekly, R. Matthew, Allais, Christophe

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Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment von Algera, Russell F., Allais, Christophe, Becirovic, Husein, Brown, Adam R., Chen, Bo, Clarke, Hugh J., Concannon, Paul E., Du, Yansheng, Georgian, William, Lee, Johnny W., Lee, Taegyo, Magano, Javier, Perez Mandry, Carlos, Mehta, Ruchi, Mull, Eric, Pearson, Robert, Peng, Zhihui, Piper, Jared L., Ragan, John A., Reyes, Giselle, Shen, Haibo, Ward, Daniel W., Weekly, R. Matthew, Weisenburger, Gerald A., Xu, Pengcheng, Yayla, Hatice G., Zhang, Mengtan

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