Functional Drug Screen Identifies Thiostrepton, NAMPT Inhibitors and Metformin As Potential Candidates to Target the Macrophage Tumor Microenvironment in Acute Myeloid Leukemia von Weinhaeuser, Isabel, Pereira-Martins, Diego, Hilberink, Jacobien R, Ammatuna, Emanuele, Huls, Gerwin A., Rego, Eduardo M, Schuringa, Jan Jacob

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Metformin-Induced Ferroptosis Is a Therapeutic Vulnerability in IDH2-Mutant AML Linked to Metabolic Rewiring Towards Fatty Acid Oxidation von Sternadt, Dominique, Pereira-Martins, Diego, Silveira, Douglas RA, Weinhaeuser, Isabel, Yang, Ming, Chatzikyriakou, Prodromos, Casares Alaez, Pilar, Ammatuna, Emanuele, Oudejans, Lieve, Huls, Gerwin A., Frezza, Christian, Quek, Lynn, Schuringa, Jan Jacob

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M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment von Weinhaeuser, Isabel, Pereira-Martins, Diego, Yamamoto de Almeida, Luciana, Hilberink, Jacobien R, Silveira, Douglas RA, Quek, Lynn, Ortiz, César Alexander, Lucena-Araujo, Antonio R., Visser, Nienke, Ammatuna, Emanuele, Huls, Gerwin A., Rego, Eduardo M, Schuringa, Jan Jacob

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Impaired Metabolic Plasticity Under Stress Constitutes a Therapeutic Vulnerability in IDH1/2-Mutant Acute Myeloid Leukemia von Sternadt, Dominique, Pereira-Martins, Diego, Silveira, Douglas RA, Chatzikyriakou, Prodromos, Casares Alaez, Maria del Pilar, Weinhaeuser, Isabel, Hogeling, Shanna M, Ammatuna, Emanuele, Huls, Gerwin A., Quek, Lynn, Schuringa, Jan Jacob

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CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia von Pereira-Martins, Diego, Ortiz Rojas, César Alexander, Weinhaeuser, Isabel, Wierenga, Bart-Jan, Van Den Boom, Vincent, Mojallali, Fatemeh, Sternadt, Dominique, Bianco, Thiago Mantello, van der Meer, Nisha, Silveira, Douglas RA, Quek, Lynn, Ammatuna, Emanuele, Lucena-Araujo, Antonio R, Huls, Gerwin A., Rego, Eduardo Magalhães, Schuringa, Jan Jacob

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Metabolism-Related Features Identify the Combination Metformin Plus NAMPT Inhibitors As a Selective Treatment Strategy in Acute Myeloid Leukemia von Weinhaeuser, Isabel, Pereira-Martins, Diego, Sternadt, Dominique, Griessinger, Emmanuel F, Silveira, Douglas RA, Coelho-Silva, Juan L, Alves-Silva, Antonio Bruno, Erdem, Ayşegül, Duarte, Bruno Koza Lino, Quek, Lynn, Traina, Fabiola, Saad, Sara Teresinha Olalla, Hilberink, Jacobien R, Ammatuna, Emanuele, Rego, Eduardo Magalhães, Huls, Geert A., Lucena-Araujo, Antonio R, Schuringa, Jan Jacob

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CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53 mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia von Pereira-Martins, Diego, Ortiz Rojas, César Alexander, Weinhaeuser, Isabel, Wierenga, Bart-Jan, Van Den Boom, Vincent, Mojallali, Fatemeh, Sternadt, Dominique, Bianco, Thiago Mantello, van der Meer, Nisha, Silveira, Douglas RA, Quek, Lynn, Ammatuna, Emanuele, Lucena-Araujo, Antonio R, Huls, Gerwin A., Rego, Eduardo Magalhães, Schuringa, Jan Jacob

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High MN1 Expression Is Associated with an Lspc-Enriched Phenotype and Glycolysis Representing a New Vulnerability in Acute Myeloid Leukemia von Pereira-Martins, Diego, van Dijk, Noortje, Weinhaeuser, Isabel, Silveira, Douglas RA, Coelho Da Silva, Juan, Bianco, Thiago M, Ortiz, César Alexander, Traina, Fabiola, Figueiredo-Pontes, Lorena L, Ammatuna, Emanuele, Quek, Lynn, Huls, Gerwin A., Lucena-Araujo, Antonio R., Rego, Eduardo M, Schuringa, Jan Jacob

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High ME1 Expression Is a Molecular Predictor of Post-Transplant Survival of Patients with Acute Myeloid Leukemia von Ortiz Rojas, César Alexander, Costa-Neto, Abel, Pereira-Martins, Diego A, Le, Duy Minh, Sternadt, Dominique, Weinhäuser, Isabel, Huls, Gerwin, Schuringa, Jan Jacob, Magalhães Rego, Eduardo

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The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells von de Almeida, Luciana Yamamoto, Pereira-Martins, Diego A., Weinhaeuser, Isabel, Ortiz, Cesar, Candido, Larissa A., Lange, Ana Paula, De Abreu, Nayara F., Mendonza, Silvia E. S., de Deus Wagatsuma, Virginia M., Do Nascimento, Mariane C., Paiva, Helder H., Alves-Paiva, Raquel M., Bonaldo, Camila C. O. M., Nascimento, Daniele C., Alves-Filho, Jose C., Scheucher, Priscila S., Lima, Ana Silvia G., Schuringa, Jan Jacob, Ammantuna, Emanuele, Ottone, Tiziana, Noguera, Nelida I., Araujo, Cleide L., Rego, Eduardo M.

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