Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP von Zhou, Yi, Fei, Mingjian, Zhang, Gu, Liang, Wei-Ching, Lin, WeiYu, Wu, Yan, Piskol, Robert, Ridgway, John, McNamara, Erin, Huang, Haochu, Zhang, Juan, Oh, Jaehak, Patel, Jaina M., Jakubiak, Diana, Lau, Jeff, Blackwood, Beth, Bravo, Daniel D., Shi, Yongchang, Wang, Jianyong, Hu, Hong-Ming, Lee, Wyne P., Jesudason, Rajiv, Sangaraju, Dewakar, Modrusan, Zora, Anderson, Keith R., Warming, Søren, Roose-Girma, Merone, Yan, Minhong

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A novel, label‐free, pre‐equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells von Janezic, Eric M., Doan, Alexander, Mai, Elaine, Bravo, Daniel D., Wang, Jianyong, Kim, Hok Seon, Spiess, Christoph, Bewley, Kathryn, ElSohly, Adel, Liang, Wei‐Ching, Koerber, James T., Richalet, Pascale, Vanhove, Marc, Comps‐Agrar, Laetitia

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Rapid identification of anti-idiotypic mAbs with high affinity and diverse epitopes by rabbit single B-cell sorting-culture and cloning technology von Lin, WeiYu, Liang, Wei-Ching, Nguy, Trung, Maia, Mauricio, Tyagi, Tulika, Chiu, Cecilia, Hoi, Kam Hon, Chen, Yongmei, Wu, Yan

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis von Yan, Minhong, Ridgway, John, Zhang, Gu, Wu, Yan, Stawicki, Scott, Liang, Wei-Ching, Chanthery, Yvan, Kowalski, Joe, Watts, Ryan J, Callahan, Christopher, Kasman, Ian, Singh, Mallika, Chien, May, Tan, Christine, Hongo, Jo-Anne S, de Sauvage, Fred, Plowman, Greg

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Dramatic activation of an antibody by a single amino acid change in framework von Liang, Wei-Ching, Yin, Jianping, Lupardus, Patrick, Zhang, Jianhuan, Loyet, Kelly M., Sudhamsu, Jawahar, Wu, Yan

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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy von Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Young, Andrew Ah, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.

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An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia von Zheng, Bing, Yu, Shang-Fan, Del Rosario, Geoffrey, Leong, Steven R, Lee, Genee Y, Vij, Rajesh, Chiu, Cecilia, Liang, Wei-Ching, Wu, Yan, Chalouni, Cecile, Sadowsky, Jack, Clark, Vanessa, Hendricks, Angela, Poon, Kirsten Achilles, Chu, Wayne, Pillow, Thomas, Schutten, Melissa M, Flygare, John, Polson, Andrew G

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The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion von Fearnley, Gareth W, Young, Katherine A, Edgar, James R, Antrobus, Robin, Hay, Iain M, Liang, Wei-Ching, Martinez-Martin, Nadia, Lin, WeiYu, Deane, Janet E, Sharpe, Hayley J

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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability von Liang, Wei-Ching, Xi, Hongkang, Sun, Dawei, D'Ascenzo, Luigi, Zarzar, Jonathan, Stephens, Nicole, Cook, Ryan, Li, Yinyin, Ye, Zhengmao, Matsumoto, Marissa, Payandeh, Jian, Masureel, Matthieu, Wu, Yan

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Cross-species Vascular Endothelial Growth Factor (VEGF)-blocking Antibodies Completely Inhibit the Growth of Human Tumor Xenografts and Measure the Contribution of Stromal VEGF von Liang, Wei-Ching, Wu, Xiumin, Peale, Franklin V., Lee, Chingwei V., Meng, Y. Gloria, Gutierrez, Johnny, Fu, Ling, Malik, Ajay K., Gerber, Hans-Peter, Ferrara, Napoleone, Fuh, Germaine

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Harnessing MerTK agonism for targeted therapeutics von Kedage, Vivekananda, Ellerman, Diego, Chen, Yongmei, Liang, Wei-Ching, Borneo, Joven, Wu, Yan, Yan, Minhong

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Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding von Appleton, Brent A, Wu, Ping, Maloney, Janice, Yin, JianPing, Liang, Wei-Ching, Stawicki, Scott, Mortara, Kyle, Bowman, Krista K, Elliott, J Michael, Desmarais, William, Bazan, J Fernando, Bagri, Anil, Tessier-Lavigne, Marc, Koch, Alexander W, Wu, Yan, Watts, Ryan J, Wiesmann, Christian

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VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis von Dong, Jianying, Grunstein, Jeremy, Tejada, Max, Peale, Frank, Frantz, Gretchen, Liang, Wei-Ching, Bai, Wei, Yu, Lanlan, Kowalski, Joe, Liang, Xiaohuan, Fuh, Germaine, Gerber, Hans-Peter, Ferrara, Napoleone

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CLEC5a-directed bispecific antibody for effective cellular phagocytosis von Kedage, Vivekananda, Ellerman, Diego, Fei, Mingjian, Liang, Wei-Ching, Zhang, Gu, Cheng, Eric, Zhang, Juan, Chen, Yongmei, Huang, Haochu, Lee, Wyne P, Wu, Yan, Yan, Minhong

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Isoform-selective TGF-β3 inhibition for systemic sclerosis von Sun, Tianhe, Vander Heiden, Jason A., Gao, Xia, Yin, Jianping, Uttarwar, Salil, Liang, Wei-Ching, Jia, Guiquan, Yadav, Rajbharan, Huang, Zhiyu, Mitra, Mayurranjan, Halpern, Wendy, Bender, Hannah S., Brightbill, Hans D., Wu, Yan, Lupardus, Patrick, Ramalingam, Thirumalai, Arron, Joseph R.

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EphB4 forward signalling regulates lymphatic valve development von Zhang, Gu, Brady, John, Liang, Wei-Ching, Wu, Yan, Henkemeyer, Mark, Yan, Minhong

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Function Blocking Antibodies to Neuropilin-1 Generated from a Designed Human Synthetic Antibody Phage Library von Liang, Wei-Ching, Dennis, Mark S., Stawicki, Scott, Chanthery, Yvan, Pan, Qi, Chen, Yongmei, Eigenbrot, Charles, Yin, JianPing, Koch, Alexander W., Wu, Xiumin, Ferrara, Napoleone, Bagri, Anil, Tessier-Lavigne, Marc, Watts, Ryan J., Wu, Yan

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Structural insight into distinct mechanisms of protease inhibition by antibodies von Wu, Yan, Eigenbrot, Charles, Liang, Wei-Ching, Stawicki, Scott, Shia, Steven, Fan, Bin, Ganesan, Rajkumar, Lipari, Michael T, Kirchhofer, Daniel

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A Real-Time Image-Based Efferocytosis Assay for the Discovery of Functionally Inhibitory Anti-MerTK Antibodies von Bravo, Daniel D, Shi, Yongchang, Sheu, Allison, Liang, Wei-Ching, Lin, WeiYu, Wu, Yan, Yan, Minhong, Wang, Jianyong

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A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys von Mitra, Mayur S, Lancaster, Karla, Adedeji, Adeyemi O, Palanisamy, Gopinath S, Dave, Rutwij A, Zhong, Fiona, Holdren, Matthew S, Turley, Shannon J, Liang, Wei-Ching, Wu, Yan, Meng, Y Gloria, Vernes, Jean-Michel, Schutten, Melissa M

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