Calcium Signaling and Cardiac Arrhythmias von Landstrom, Andrew P, Dobrev, Dobromir, Wehrens, Xander H.T

Volltext

Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation von VOIGT, Niels, NA LI, WEHRENS, Xander H. T, DOBREV, Dobromir, QIONGLING WANG, WEI WANG, TRAFFORD, Andrew W, ABU-TAHA, Issam, QIANG SUN, WIELAND, Thomas, RAVENS, Ursula, NATTEL, Stanley

Volltext

Circadian rhythms govern cardiac repolarization and arrhythmogenesis von Jeyaraj, Darwin, Haldar, Saptarsi M., Wan, Xiaoping, McCauley, Mark D., Ripperger, Jürgen A., Hu, Kun, Lu, Yuan, Eapen, Betty L., Sharma, Nikunj, Ficker, Eckhard, Cutler, Michael J., Gulick, James, Sanbe, Atsushi, Robbins, Jeffrey, Demolombe, Sophie, Kondratov, Roman V., Shea, Steven A., Albrecht, Urs, Wehrens, Xander H. T., Rosenbaum, David S., Jain, Mukesh K.

Volltext

Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization von Beavers, David L., BS, Wang, Wei, PhD, Ather, Sameer, MD, PhD, Voigt, Niels, MD, Garbino, Alejandro, MD, PhD, Dixit, Sayali S., PhD, Landstrom, Andrew P., MD, PhD, Li, Na, PhD, Wang, Qiongling, PhD, Olivotto, Iacopo, MD, Dobrev, Dobromir, MD, Ackerman, Michael J., MD, PhD, Wehrens, Xander H.T., MD, PhD

Volltext

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure von Zhang, Caimei, Chen, Biyi, Guo, Ang, Zhu, Yanqi, Miller, Jordan D, Gao, Shan, Yuan, Can, Kutschke, William, Zimmerman, Kathy, Weiss, Robert M, Wehrens, Xander H T, Hong, Jiang, Johnson, Frances L, Santana, Luis F, Anderson, Mark E, Song, Long-Sheng

Volltext

Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death von Aiba, Isamu, Wehrens, Xander H. T., Noebels, Jeffrey L.

Volltext

Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice von VAN OORT, Ralph J, GARBINO, Alejandro, ACKERMAN, Michael J, WEHRENS, Xander H. T, WEI WANG, DIXIT, Sayali S, LANDSTROM, Andrew P, GAUR, Namit, DE ALMEIDA, Angela C, SKAPURA, Darlene G, RUDY, Yoram, BURNS, Alan R

Volltext

Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure von VAN OORT, Ralph J, MCCAULEY, Mark D, BERS, Donald M, WEHRENS, Xander H. T, DIXIT, Sayali S, PEREIRA, Laetitia, YI YANG, RESPRESS, Jonathan L, QIONGLING WANG, DE ALMEIDA, Angela C, SKAPURA, Darlene G, ANDERSON, Mark E

Volltext

Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1 von Koshelev, Misha, Sarma, Satyam, Price, Roger E., Wehrens, Xander H.T., Cooper, Thomas A.

Volltext

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation von Voigt, Niels, Heijman, Jordi, Wang, Qiongling, Chiang, David Y, Li, Na, Karck, Matthias, Wehrens, Xander H.T, Nattel, Stanley, Dobrev, Dobromir

Volltext

Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance von Dixit, Sayali S, Wang, Tiannan, Manzano, Eiffel John Q, Yoo, Shin, Lee, Jeongkyung, Chiang, David Y, Ryan, Nicole, Respress, Jonathan L, Yechoor, Vijay K, Wehrens, Xander H T

Volltext

Genome Editing and Cardiac Arrhythmias von Moore, Oliver M, Ho, Kevin S, Copeland, Juwan S, Parthasarathy, Vaidya, Wehrens, Xander H T

Volltext

NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy von Dardas, Zain, Fatih, Jawid M, Jolly, Angad, Dawood, Moez, Du, Haowei, Grochowski, Christopher M, Jones, Edward G, Jhangiani, Shalini N, Wehrens, Xander H T, Liu, Pengfei, Bi, Weimin, Boerwinkle, Eric, Posey, Jennifer E, Muzny, Donna M, Gibbs, Richard A, Lupski, James R, Coban-Akdemir, Zeynep, Morris, Shaine A

Volltext

Protection from Cardiac Arrhythmia through Ryanodine Receptor-Stabilizing Protein Calstabin2 von Xander H. T. Wehrens, Lehnart, Stephan E., Reiken, Steven R., Deng, Shi-Xian, Vest, John A., Cervantes, Daniel, Coromilas, James, Landry, Donald W., Marks, Andrew R.

Volltext

Ryanodine Receptor/Calcium Release Channel PKA Phosphorylation: A Critical Mediator of Heart Failure Progression von Wehrens, Xander H. T., Lehnart, Stephan E., Reiken, Steven, Vest, John A., Wronska, Anetta, Marks, Andrew R.

Volltext

Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation von CUNHA, Shane R, HUND, Thomas J, KARCK, Matthias, SCHOTT, Jean-Jacques, PROBST, Vincent, LE MAREC, Herve, ANDERSON, Mark E, DOBREV, Dobromir, WEHRENS, Xander H. T, MOHLER, Peter J, HASHEMI, Seyed, VOIGT, Niels, NA LI, WRIGHT, Patrick, KOVAL, Olha, JINGDONG LI, GUDMUNDSSON, Hjalti, GUMINA, Richard J

Volltext

SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice von Hinton, Jr, Antentor Othrell, Yang, Yongjie, Quick, Ann P, Xu, Pingwen, Reddy, Chitra L, Yan, Xiaofeng, Reynolds, Corey L, Tong, Qingchun, Zhu, Liangru, Xu, Jianming, Wehrens, Xander H T, Xu, Yong, Reddy, Anilkumar K

Volltext

Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation von Shao, Chun-Hong, Wehrens, Xander H. T, Wyatt, Todd A, Parbhu, Sheeva, Rozanski, George J, Patel, Kaushik P, Bidasee, Keshore R

Volltext

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure von Shen, Xin, van den Brink, Jonas, Bergan-Dahl, Anna, Kolstad, Terje R, Norden, Einar S, Hou, Yufeng, Laasmaa, Martin, Aguilar-Sanchez, Yuriana, Quick, Ann P, Espe, Emil KS, Sjaastad, Ivar, Wehrens, Xander HT, Edwards, Andrew G, Soeller, Christian, Louch, William E

Volltext

Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction von Ather, Sameer, MD, Chan, Wenyaw, PhD, Bozkurt, Biykem, MD, PhD, Aguilar, David, MD, Ramasubbu, Kumudha, MD, Zachariah, Amit A., MD, Wehrens, Xander H.T., MD, PhD, Deswal, Anita, MD, MPH

Volltext