Deciphering Signatures of Mutational Processes Operative in Human Cancer von Alexandrov, Ludmil B., Nik-Zainal, Serena, Wedge, David C., Campbell, Peter J., Stratton, Michael R.

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High burden and pervasive positive selection of somatic mutations in normal human skin von Martincorena, Iñigo, Roshan, Amit, Gerstung, Moritz, Ellis, Peter, Van Loo, Peter, McLaren, Stuart, Wedge, David C., Fullam, Anthony, Alexandrov, Ludmil B., Tubio, Jose M., Stebbings, Lucy, Menzies, Andrew, Widaa, Sara, Stratton, Michael R., Jones, Philip H., Campbell, Peter J.

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Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis von Petljak, Mia, Alexandrov, Ludmil B., Brammeld, Jonathan S., Price, Stacey, Wedge, David C., Grossmann, Sebastian, Dawson, Kevin J., Ju, Young Seok, Iorio, Francesco, Tubio, Jose M.C., Koh, Ching Chiek, Georgakopoulos-Soares, Ilias, Rodríguez–Martín, Bernardo, Otlu, Burçak, O’Meara, Sarah, Butler, Adam P., Menzies, Andrew, Bhosle, Shriram G., Raine, Keiran, Jones, David R., Teague, Jon W., Beal, Kathryn, Latimer, Calli, O’Neill, Laura, Zamora, Jorge, Anderson, Elizabeth, Patel, Nikita, Maddison, Mark, Ng, Bee Ling, Graham, Jennifer, Garnett, Mathew J., McDermott, Ultan, Nik-Zainal, Serena, Campbell, Peter J., Stratton, Michael R.

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The evolutionary history of lethal metastatic prostate cancer von Gundem, Gunes, Van Loo, Peter, Kremeyer, Barbara, Alexandrov, Ludmil B., Tubio, Jose M. C., Papaemmanuil, Elli, Brewer, Daniel S., Kallio, Heini M. L., Högnäs, Gunilla, Annala, Matti, Kivinummi, Kati, Goody, Victoria, Latimer, Calli, O'Meara, Sarah, Dawson, Kevin J., Isaacs, William, Emmert-Buck, Michael R., Nykter, Matti, Foster, Christopher, Kote-Jarai, Zsofia, Easton, Douglas, Whitaker, Hayley C., Neal, David E., Cooper, Colin S., Eeles, Rosalind A., Visakorpi, Tapio, Campbell, Peter J., McDermott, Ultan, Wedge, David C., Bova, G. Steven

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Genomic landscape and chronological reconstruction of driver events in multiple myeloma von Maura, Francesco, Bolli, Niccoló, Angelopoulos, Nicos, Dawson, Kevin J., Leongamornlert, Daniel, Martincorena, Inigo, Mitchell, Thomas J., Fullam, Anthony, Gonzalez, Santiago, Szalat, Raphael, Abascal, Federico, Rodriguez-Martin, Bernardo, Samur, Mehmet Kemal, Glodzik, Dominik, Roncador, Marco, Fulciniti, Mariateresa, Tai, Yu Tzu, Minvielle, Stephane, Magrangeas, Florence, Moreau, Philippe, Corradini, Paolo, Anderson, Kenneth C., Tubio, Jose M. C., Wedge, David C., Gerstung, Moritz, Avet-Loiseau, Hervé, Munshi, Nikhil, Campbell, Peter J.

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Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing von Zhang, Jianjun, Fujimoto, Junya, Zhang, Jianhua, Wedge, David C., Song, Xingzhi, Zhang, Jiexin, Seth, Sahil, Chow, Chi-Wan, Cao, Yu, Gumbs, Curtis, Gold, Kathryn A., Kalhor, Neda, Little, Latasha, Mahadeshwar, Harshad, Moran, Cesar, Protopopov, Alexei, Sun, Huandong, Tang, Jiabin, Wu, Xifeng, Ye, Yuanqing, William, William N., Lee, J. Jack, Heymach, John V., Hong, Waun Ki, Swisher, Stephen, Wistuba, Ignacio I., Futreal, P. Andrew

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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics von Li, Xiaodun, Francies, Hayley E., Secrier, Maria, Perner, Juliane, Miremadi, Ahmad, Galeano-Dalmau, Núria, Barendt, William J., Letchford, Laura, Leyden, Genevieve M., Goffin, Emma K., Barthorpe, Andrew, Lightfoot, Howard, Chen, Elisabeth, Gilbert, James, Noorani, Ayesha, Devonshire, Ginny, Bower, Lawrence, Grantham, Amber, MacRae, Shona, Grehan, Nicola, Wedge, David C., Fitzgerald, Rebecca C., Garnett, Mathew J.

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Effect of Mutation Order on Myeloproliferative Neoplasms von Ortmann, Christina A, Kent, David G, Nangalia, Jyoti, Silber, Yvonne, Wedge, David C, Grinfeld, Jacob, Baxter, E. Joanna, Massie, Charles E, Papaemmanuil, Elli, Menon, Suraj, Godfrey, Anna L, Dimitropoulou, Danai, Guglielmelli, Paola, Bellosillo, Beatriz, Besses, Carles, Döhner, Konstanze, Harrison, Claire N, Vassiliou, George S, Vannucchi, Alessandro, Campbell, Peter J, Green, Anthony R

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Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone von Behjati, Sam, Tarpey, Patrick S, Presneau, Nadège, Scheipl, Susanne, Pillay, Nischalan, Van Loo, Peter, Wedge, David C, Cooke, Susanna L, Gundem, Gunes, Davies, Helen, Nik-Zainal, Serena, Martin, Sancha, McLaren, Stuart, Goody, Victoria, Robinson, Ben, Butler, Adam, Teague, Jon W, Halai, Dina, Khatri, Bhavisha, Myklebost, Ola, Baumhoer, Daniel, Jundt, Gernot, Hamoudi, Rifat, Tirabosco, Roberto, Amary, M Fernanda, Futreal, P Andrew, Stratton, Michael R, Campbell, Peter J, Flanagan, Adrienne M

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Genomic copy number predicts esophageal cancer years before transformation von Killcoyne, Sarah, Gregson, Eleanor, Wedge, David C., Woodcock, Dan J., Eldridge, Matthew D., de la Rue, Rachel, Miremadi, Ahmad, Abbas, Sujath, Blasko, Adrienn, Kosmidou, Cassandra, Januszewicz, Wladyslaw, Jenkins, Aikaterini Varanou, Gerstung, Moritz, Fitzgerald, Rebecca C.

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Genomic patterns of progression in smoldering multiple myeloma von Bolli, Niccolò, Maura, Francesco, Minvielle, Stephane, Gloznik, Dominik, Szalat, Raphael, Fullam, Anthony, Martincorena, Inigo, Dawson, Kevin J., Samur, Mehmet Kemal, Zamora, Jorge, Tarpey, Patrick, Davies, Helen, Fulciniti, Mariateresa, Shammas, Masood A., Tai, Yu Tzu, Magrangeas, Florence, Moreau, Philippe, Corradini, Paolo, Anderson, Kenneth, Alexandrov, Ludmil, Wedge, David C., Avet-Loiseau, Herve, Campbell, Peter, Munshi, Nikhil

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Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma von Hua, Xing, Zhao, Wei, Pesatori, Angela C., Consonni, Dario, Caporaso, Neil E., Zhang, Tongwu, Zhu, Bin, Wang, Mingyi, Jones, Kristine, Hicks, Belynda, Song, Lei, Sampson, Joshua, Wedge, David C., Shi, Jianxin, Landi, Maria Teresa

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Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer von Hong, Matthew K.H., Macintyre, Geoff, Wedge, David C., Van Loo, Peter, Patel, Keval, Lunke, Sebastian, Alexandrov, Ludmil B., Sloggett, Clare, Cmero, Marek, Marass, Francesco, Tsui, Dana, Mangiola, Stefano, Lonie, Andrew, Naeem, Haroon, Sapre, Nikhil, Phal, Pramit M., Kurganovs, Natalie, Chin, Xiaowen, Kerger, Michael, Warren, Anne Y., Neal, David, Gnanapragasam, Vincent, Rosenfeld, Nitzan, Pedersen, John S., Ryan, Andrew, Haviv, Izhak, Costello, Anthony J., Corcoran, Niall M., Hovens, Christopher M.

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Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma von Behjati, Sam, Tarpey, Patrick S., Haase, Kerstin, Ye, Hongtao, Young, Matthew D., Alexandrov, Ludmil B., Farndon, Sarah J., Collord, Grace, Wedge, David C., Martincorena, Inigo, Cooke, Susanna L., Davies, Helen, Mifsud, William, Lidgren, Mathias, Martin, Sancha, Latimer, Calli, Maddison, Mark, Butler, Adam P., Teague, Jon W., Pillay, Nischalan, Shlien, Adam, McDermott, Ultan, Futreal, P. Andrew, Baumhoer, Daniel, Zaikova, Olga, Bjerkehagen, Bodil, Myklebost, Ola, Amary, M. Fernanda, Tirabosco, Roberto, Van Loo, Peter, Stratton, Michael R., Flanagan, Adrienne M., Campbell, Peter J.

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Re-evaluating experimental validation in the Big Data Era: a conceptual argument von Jafari, Mohieddin, Guan, Yuanfang, Wedge, David C., Ansari-Pour, Naser

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DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype von Nangalia, Jyoti, Nice, Francesca L, Wedge, David C, Godfrey, Anna L, Grinfeld, Jacob, Thakker, Clare, Massie, Charlie E, Baxter, Joanna, Sewell, David, Silber, Yvonne, Campbell, Peter J, Green, Anthony R

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APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types von Jakobsdottir, G Maria, Brewer, Daniel S, Cooper, Colin, Green, Catherine, Wedge, David C

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Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets von BROWN, Marie, WEDGE, David C, GOODACRE, Royston, KELL, Douglas B, BAKER, Philip N, KENNY, Louise C, MAMAS, Mamas A, NEYSES, Ludwig, DUNN, Warwick B

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Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors von Cheng, Jiqiu, Demeulemeester, Jonas, Wedge, David C., Vollan, Hans Kristian M., Pitt, Jason J., Russnes, Hege G., Pandey, Bina P., Nilsen, Gro, Nord, Silje, Bignell, Graham R., White, Kevin P., Børresen-Dale, Anne-Lise, Campbell, Peter J., Kristensen, Vessela N., Stratton, Michael R., Lingjærde, Ole Christian, Moreau, Yves, Van Loo, Peter

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Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils von Kwon, Young Mi, Gori, Kevin, Park, Naomi, Potts, Nicole, Swift, Kate, Wang, Jinhong, Stammnitz, Maximilian R., Cannell, Naomi, Baez-Ortega, Adrian, Comte, Sebastien, Fox, Samantha, Harmsen, Colette, Huxtable, Stewart, Jones, Menna, Kreiss, Alexandre, Lawrence, Clare, Lazenby, Billie, Peck, Sarah, Pye, Ruth, Woods, Gregory, Zimmermann, Mona, Wedge, David C., Pemberton, David, Stratton, Michael R., Hamede, Rodrigo, Murchison, Elizabeth P.

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