A recurring pattern of chromosomal aberrations in mammary gland tumors of MMTV-cmyc transgenic mice von Weaver, Zoë A., McCormack, Stephen J., Liyanage, Marek, du Manoir, Stan, Coleman, Allen, Schröck, Evelin, Dickson, Robert B., Ried, Thomas

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Genomic Characterization of a Testis-Specific TFIIS (TCEA2) Gene von Weaver, Zoe A., Kane, Caroline M.

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Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models von Lissa, Delphine, Takahashi, Nobuyuki, Desai, Parth, Manukyan, Irena, Schultz, Christopher W., Rajapakse, Vinodh, Velez, Moises J., Mulford, Deborah, Roper, Nitin, Nichols, Samantha, Vilimas, Rasa, Sciuto, Linda, Chen, Yuanbin, Guha, Udayan, Rajan, Arun, Atkinson, Devon, El Meskini, Rajaa, Weaver Ohler, Zoe, Thomas, Anish

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Distinct Biomarker Profiles and TCR Sequence Diversity Characterize the Response to PD-L1 Blockade in a Mouse Melanoma Model von El Meskini, Rajaa, Atkinson, Devon, Kulaga, Alan, Abdelmaksoud, Abdalla, Gumprecht, Michelle, Pate, Nathan, Hayes, Susana, Oberst, Michael, Kaplan, Ian M, Raber, Patrick, Van Dyke, Terry, Sharan, Shyam K, Hollingsworth, Robert, Day, Chi-Ping, Merlino, Glenn, Weaver Ohler, Zoë

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A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors von El Meskini, Rajaa, Iacovelli, Anthony J, Kulaga, Alan, Gumprecht, Michelle, Martin, Philip L, Baran, Maureen, Householder, Deborah B, Van Dyke, Terry, Weaver Ohler, Zoë

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Translational Orthotopic Models of Glioblastoma Multiforme von El Meskini, Rajaa, Atkinson, Devon, Weaver Ohler, Zoë

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Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer von Abraham, Marc, Kordatou, Zoe, Barriuso, Jorge, Lamarca, Angela, Weaver, Jamie M J, Cipriano, Claudia, Papaxoinis, George, Backen, Alison, Mansoor, Wasat

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Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy von Pérez-Guijarro, Eva, Yang, Howard H., Araya, Romina E., El Meskini, Rajaa, Michael, Helen T., Vodnala, Suman Kumar, Marie, Kerrie L., Smith, Cari, Chin, Sung, Lam, Khiem C., Thorkelsson, Andres, Iacovelli, Anthony J., Kulaga, Alan, Fon, Anyen, Michalowski, Aleksandra M., Hugo, Willy, Lo, Roger S., Restifo, Nicholas P., Sharan, Shyam K., Van Dyke, Terry, Goldszmid, Romina S., Weaver Ohler, Zoe, Lee, Maxwell P., Day, Chi-Ping, Merlino, Glenn

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells von Xu, X, Weaver, Z, Linke, S P, Li, C, Gotay, J, Wang, X W, Harris, C C, Ried, T, Deng, C X

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The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib von Marzi, Laetitia, Szabova, Ludmila, Gordon, Melanie, Weaver Ohler, Zoe, Sharan, Shyam K, Beshiri, Michael L, Etemadi, Moudjib, Murai, Junko, Kelly, Kathleen, Pommier, Yves

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Abstract A162: Continuous treatment with rociletinib in EGFR transgenic mice results in acquired resistance to both rociletinib and osimertinib and intra-“patient” tumor heterogene... von El Meskini, Rajaa, Iacovelli, Anthony, Kulaga, Alan, Gumprecht, Michelle, Spencer, Myla, Ileva, Lilia, Simmons, Andrew, Weaver Ohler, Zoë

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Near Infrared Photoimmunotherapy in a Transgenic Mouse Model of Spontaneous Epidermal Growth Factor Receptor (EGFR)-expressing Lung Cancer von Nakamura, Yuko, Ohler, Zoe Weaver, Householder, Deborah, Nagaya, Tadanobu, Sato, Kazuhide, Okuyama, Shuhei, Ogata, Fusa, Daar, Dagane, Hoa, Tieu, Choyke, Peter L, Kobayashi, Hisataka

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Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice von Liyanage, Marek, Weaver, Zoë, Barlow, Carrolee, Coleman, Allen, Pankratz, Daniel G., Anderson, Stacie, Wynshaw-Boris, Anthony, Ried, Thomas

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"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts von Day, Chi-Ping, Carter, John, Weaver Ohler, Zoe, Bonomi, Carrie, El Meskini, Rajaa, Martin, Philip, Graff-Cherry, Cari, Feigenbaum, Lionel, Tüting, Thomas, Van Dyke, Terry, Hollingshead, Melinda, Merlino, Glenn

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Ataxia telangiectasia mutated is essential during adult neurogenesis von Allen, D M, van Praag, H, Ray, J, Weaver, Z, Winrow, C J, Carter, T A, Braquet, R, Harrington, E, Ried, T, Brown, K D, Gage, F H, Barlow, C

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Whole-genome sequencing reveals host factors underlying critical COVID-19 von Kousathanas, Athanasios, Pairo-Castineira, Erola, Rawlik, Konrad, Stuckey, Alex, Odhams, Christopher A., Walker, Susan, Russell, Clark D., Malinauskas, Tomas, Wu, Yang, Millar, Jonathan, Shen, Xia, Elliott, Katherine S., Griffiths, Fiona, Oosthuyzen, Wilna, Morrice, Kirstie, Keating, Sean, Wang, Bo, Rhodes, Daniel, Klaric, Lucija, Zechner, Marie, Parkinson, Nick, Siddiq, Afshan, Goddard, Peter, Donovan, Sally, Maslove, David, Nichol, Alistair, Semple, Malcolm G., Zainy, Tala, Maleady-Crowe, Fiona, Todd, Linda, Salehi, Shahla, Knight, Julian, Elgar, Greg, Chan, Georgia, Arumugam, Prabhu, Patch, Christine, Rendon, Augusto, Bentley, David, Kingsley, Clare, Kosmicki, Jack A., Horowitz, Julie E., Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A. R., Justice, Anne, Mirshahi, Tooraj, Oetjens, Matthew, Rader, Daniel J., Ritchie, Marylyn D., Verma, Anurag, Fowler, Tom A., Shankar-Hari, Manu, Summers, Charlotte, Hinds, Charles, Horby, Peter, Ling, Lowell, McAuley, Danny, Montgomery, Hugh, Openshaw, Peter J. M., Elliott, Paul, Walsh, Timothy, Tenesa, Albert, Fawkes, Angie, Murphy, Lee, Rowan, Kathy, Ponting, Chris P., Vitart, Veronique, Wilson, James F., Yang, Jian, Bretherick, Andrew D., Scott, Richard H., Hendry, Sara Clohisey, Moutsianas, Loukas, Law, Andy, Caulfield, Mark J., Baillie, J. Kenneth

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Temporal Molecular and Biological Assessment of an Erlotinib-Resistant Lung Adenocarcinoma Model Reveals Markers of Tumor Progression and Treatment Response von WEAVER, Zoë, DIFILIPPANTONIO, Simone, BARAN, Maureen, KOZLOV, Serguei, MCCANN, Thomas, MENA, Salvador, AL-SHAHROUR, Fatima, ALEXANDER, Danny, WONG, Kwok-Kin, VAN DYKE, Terry, CARRETERO, Julian, MARTIN, Philip L, EL MESKINI, Rajaa, LACOVELLI, Anthony J, GUMPRECHT, Michelle, KULAGA, Alan, GUERIN, Theresa, SCHLOMER, Jerome

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Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer von Roper, Nitin, Brown, Anna-Leigh, Wei, Jun S., Pack, Svetlana, Trindade, Christopher, Kim, Chul, Restifo, Olivia, Gao, Shaojian, Sindiri, Sivasish, Mehrabadi, Farid, El Meskini, Rajaa, Ohler, Zoe Weaver, Maity, Tapan K., Venugopalan, Abhilash, Cultraro, Constance M., Akoth, Elizabeth, Padiernos, Emerson, Chen, Haobin, Kesarwala, Aparna, Smart, DeeDee K., Nilubol, Naris, Rajan, Arun, Piotrowska, Zofia, Xi, Liqiang, Raffeld, Mark, Panchenko, Anna R., Sahinalp, Cenk, Hewitt, Stephen, Hoang, Chuong D., Khan, Javed, Guha, Udayan

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ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer von Schultz, Christopher W, Zhang, Yang, Elmeskini, Rajaa, Zimmermann, Astrid, Fu, Haiqing, Murai, Yasuhisa, Wangsa, Darawalee, Kumar, Suresh, Takahashi, Nobuyuki, Atkinson, Devon, Saha, Liton Kumar, Lee, Chien‐Fei, Elenbaas, Brian, Desai, Parth, Sebastian, Robin, Sharma, Ajit Kumar, Abel, Melissa, Schroeder, Brett, Krishnamurthy, Manan, Kumar, Rajesh, Roper, Nitin, Aladjem, Mirit, Zenke, Frank T, Ohler, Zoe Weaver, Pommier, Yves, Thomas, Anish

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation von Deng, Chu-Xia, Xu, Xiaoling, Wagner, Kay-Uwe, Larson, Denise, Weaver, Zoë, Li, Cuiling, Ried, Thomas, Hennighausen, Lothar, Wynshaw-Boris, Anthony

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