Asymmetric Catalysis in the Pharmaceutical Industry von Hawkins, Joel M., Watson, Timothy J. N.

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The Selection and Control of Starting Materials Should be Governed by Science and Risk-Based Approaches von Watson, Timothy J. N., Nosal, Roger, Lepore, John, Montgomery, Frank

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Synthesis of the kappa-agonist CJ-15,161 via a palladium-catalyzed cross-coupling reaction von Ghosh, Arun, Sieser, Janice E, Caron, Stéphane, Watson, Timothy J N

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The Use of Glycidyl Ethers Involving Aziridinium Intermediates and Other Methodology for the Preparation of Enantiomerically Pure Drug Candidates von Ayers, Timothy A, Watson, Timothy J. N, Subotkowski, Witold, Daniel, John, Webster, Mark

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API Quality by Design Example from the Torcetrapib Manufacturing Process von am Ende, Dave, Bronk, Karen S., Mustakis, Jason, O’Connor, Gary, Santa Maria, Charles L., Nosal, Roger, Watson, Timothy J. N.

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Misunderstanding Design Space: a Robust Drug Product Control Strategy Is the Key to Quality Assurance von Watson, Timothy J. N., Nosal, Roger, Lepore, John, Montgomery, Frank

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Alternative Synthesis of Septic Shock Candidate 3,4-Dihydro-3,3-dimethylisoquinoline N-Oxide (MDL 101002) Utilizing an Improved Pictet−Spengler Reaction von Watson, Timothy J. N

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Chemical Development of MDL 103371:  An N-Methyl-d-Aspartate-Type Glycine Receptor Antagonist for the Treatment of Stroke von Watson, Timothy J. N, Horgan, Stephen W, Shah, Ramnik S, Farr, Robert A, Schnettler, Richard A, Nevill, C. Richard, Weiberth, Franz J, Huber, Edward W, Baron, Bruce M, Webster, Mark E, Mishra, Rajesh K, Harrison, Boyd L, Nyce, Phillip L, Rand, Cynthia L, Goralski, Christian T

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Development of the Carbocyclic Nucleoside MDL 201449A:  A Tumor Necrosis Factor-α Inhibitor von Watson, Timothy J. N, Curran, Timothy T, Hay, David A, Shah, Ramnik S, Wenstrup, David L, Webster, Mark E

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Utilization of the Phenylthio Substituent as a Multipurpose Synthetic Tool. Direct Application to the Enantioselective Construction of (−)-Salsolene Oxide von Paquette, Leo A, Sun, Li-Qiang, Watson, Timothy J. N, Friedrich, Dirk, Freeman, Brett T

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Bridgehead Oxiranyl Sesquiterpenoids. Asymmetric Total Synthesis of (−)-Salsolene Oxide von Paquette, Leo A, Sun, Li-Qiang, Watson, Timothy J. N, Friedrich, Dirk, Freeman, Brett T

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A Science and Risk Based Proposal for Understanding Scale and Equipment Dependencies of Small Molecule Drug Substance Manufacturing Processes von am Ende, David J., Seymour, Christine B., Watson, Timothy J. N.

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Verification of Design Spaces Developed at Subscale von Garcia, Thomas, McCurdy, Vincent, Watson, Timothy N. J., am Ende, Mary, Butterell, Penny, Vukovinsky, Kimberly, Chueh, Alex, Coffman, Jonathan, Cooper, Simon, Schuemmelfeder, Bernd

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A Design Space Verification Protocol for a Small Molecule Drug Substance von Watson, Timothy J. N., Bonsignore, Holly, Callaghan-Manning, Eileen A., Colgan, Stephen T., Fitzsimons, Paul, Garcia, Thomas P., Groskoph, John G., Lynch, Michael P., Nosal, Roger, McMahon, Megan E., Singer, Robert A., Thomson, Nicholas M., Sluggett, Gregory W., Schulz, Darren J., Twohig, Shirley

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Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate von Brian M. Andresen, Brian C. Vanderplas, John L. Tucker, Janice E. Sieser, Maxime Riou, Teresa M. Makowski, Joel M. Hawkins, Melina Girardin, Arun Ghosh, Kristina Dupont-Gaudet, Nga M. Do, Keith M. DeVries, Michel Couturier, Stéphane Caron, Timothy J.N. Watson

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Asymmetrische Katalyse in der pharmazeutischen Industrie von Hawkins, Joel M., Watson, Timothy J. N.

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A Scaleable Method for Preparing 3-Fluorenylmethoxycarbonylamino-5-Hydroxybenzoic Acid von Watson, Timothy J. N., Flynn, Gary A., Shah, Ramnik S.

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Asymmetrische Katalyse in der pharmazeutischen Industrie von Hawkins, Joel M., Watson, Timothy J. N.

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Asymmetric Catalysis in the Pharmaceutical Industry von Hawkins, Joel M., Watson, Timothy J. N.

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Method for preparing indan-1,3-dicarboxylic acid von ARPIN PATRICE,GUZMAN MARK C.,WATSON TIMOTHY J. N

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