MA12.08 Growth Pattern Evolution of Lung Adenocarcinoma from Primary Tumour to Metastasis in TRACERx von Karasaki, T., Moore, D.A., Huebner, A., Al Bakir, M., Frankell, A.M., Grigoriadis, K., Watkins, T.B.K., McGranahan, N., Swanton, C., Jamal-Hanjani, M.

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1228P Integrated analysis of gene expression and chromosomal aberrations to determine the global patterns of DNA methylation heterogeneity in the TRACERx lung study von Gimeno-Valiente, F., Chen, K., Cadieux, E.L., Watkins, T.B.K., Chervova, O., Dhami, P., Vaikkinen, H., Feber, A., Demeulemeester, J., Tanic, M., Beck, S., Van Loo, P., Kanu, N., Swanton, C.

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MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution von Puttick, C, Leung, M.M, Black, J.R.M, Rosenthal, R, Jamal-Hanjani, M, Cheyne, H, Khalil, M, Richardson, S, Aerts, H.J.W.L, Kaufmann, T.L, Huska, M.R, Bailey, C, Vendramin, R, Murphy, C, McGranahan, N, Castignani, C, Kittel, J, Haase, K, Scott, R, Matharu, G, Hackshaw, A, Leslie, R, Abbosh, C, Naceur-Lombardelli, C, Thakkar, K, Mussa, B, Magala, M, Keene, E, Lim, E.L, Black, J.R.S, Huebner, A, Grigoriadis, K, Thol, K, Liu, W.K, Bunkum, A, Karagianni, D, Swanton, C, Szallasi, Z, Borg, E, Falzon, M, Khiroya, R, Ahmad, T, Taylor, M.N, Lindsay, C.R, Blackhall, F.H, Krebs, M.G, Kirk, A, Bilancia, R, Kostoulas, N, Thomas, M, MacKenzie, M, Kidd, A, Navani, N, Thakrar, R.M, Hodgkinson, J.D, Totton, N, Tanic, M, Robinson, L, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Ambrose, L, Chavan, H, Booth, S, Nicholson, A.G, Lester, J.F, Chaturvedi, A, Oliveira, P, Brown, K.D, Carter, M, Weeden, C.E, Goldman, J, Hobson, P, Boeing, S, Denner, T, Barbè, V, Naito, Y, Kassiotis, G, Grapa, A, Chain, B, Reading, J.L, Selvaraju, K, Pawlik, P, Al-Sawaf, O, Monk, F, Choudhary, J, Gorman, P, Shackleford, H, Djearaman, M, Middleton, G, Chee, S, Georg, P, Bajaj, A, Fennell, D.A, Danson, S, Smith, E, Novasio, J, Rammohan, K, Bishop, P

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The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma von Pan, X, Coelho-Lima, J, Zhang, H, Cheung, A.H.K, Nicholson, A.G, Jamal-Hanjani, M, Le Quesne, J, Sharp, A, Leslie, R, Rice, A, Bhayani, H, Ambrose, L, Chavan, H, Begum, S, Kaniu, D, Proli, C, Hewish, M, Danson, S, Kidd, A, Asif, M, Thomas, M, Dick, C, Scotland, M, Marrone, D, Dulloo, S, Matharu, G, Shaw, J.A, Boleti, E, Cruickshank, T, Wilson, J, French, J, Langman, G, Hodgkinson, J.D, Novasio, J, Rammohan, K, Moss, S, Paiva-Correia, A, Priest, L, Gomes, F, Brown, K, Blackhall, F.H, Summers, Y, Kerr, A, Aerts, H.J.W.L, Schwarz, R.F, Rowan, A, Hill, M.S, Bakir, M.A, Puttick, C, Grigoriadis, K, Biswas, D, Athanasopoulou, F, Cadieux, E.L, Kisistok, J, Sokac, M, Magness, A, Weeden, C.E, Grönroos, E, Noorani, I, Escudero, M, Barbè, V, Dwornik, A, Karagianni, D, Matos, I.G, Reading, J.L, Hartley, J.A, Selvaraju, K, Shah, M, Wu, Y, Al-Sawaf, O, Jones, T.P, Marafioti, T, Falzon, M, Khiroya, R, Sunderland, M.W, Kanu, N, Vanloo, S, Lam, J.M, Liu, W.K, Bunkum, A, Zaccaria, S, Black, J.R.M, Bentham, R, Quezada, S.A, Forster, M.D, Herrero, J, Nye, E, Nicod, J, Hoogenboom, E.M, Monk, F, Bhakhri, K, Stephens, R.C.M, Kaplar, Z, Bandula, S, Watkins, T.B.K, Royle, G, Procter, A.J, Navani, N, Thakrar, R.M, Swanton, C

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The evolution of non-small cell lung cancer metastases in TRACERx von Al Bakir, M, Martínez-Ruiz, C, Veeriah, S, Laycock, J, Johnson, D, Rowan, A, Prymas, P, Dietzen, M, Colliver, E, Frankell, A.M, Lim, E.L, Karasaki, T, Hill, M.S, Cook, D.E, Nye, E, Stone, R.K, Middleton, G, Blackhall, F.H, Cave, J, Lawrence, D, Papadatos-Pastos, D, Lester, J.F, Bajaj, A, Ang, K, Scotland, M, Dulloo, S, Matharu, G, Shaw, J.A, Khalil, M, Benafif, S, Patel, A.J, Lacson, C, Langman, G, Djearaman, M, Leek, A, Totten, N, Granato, F, Joseph, L, Gomes, F, Priest, L, Rothwell, D.G, Schwarz, R.F, Diossy, M, Demeulemeester, J, Karamani, A, Campbell, B.B, Richard, C, Pearce, D.R, Biswas, D, Athanasopoulou, F, Matos, I, Reading, J.L, Black, J.R.M, Rane, J.K, Hartley, J.A, Selvaraju, K, Chen, K, Ensell, L, Shah, M, Leung, M, Sivakumar, M, Hobson, P, Bentham, R, Vendramin, R, Vanloo, S, Denner, T, Mourikis, T.P, Barbè, V, Lu, W.-T, Liu, W.K, Naito, Y, Royle, G, Collins-Fekete, C.-A, Clark, T, Martinoni Hoogenboom, E, Bhakhri, K, Hayward, M, Khiroya, R, Bandula, S, Sharp, A, Smith, S, Dhanda, H.K, Chan, K, Leslie, R, Scarlett, L, Lim, E, Raubenheimer, H, Chavan, H, Fernandes, N, Proli, C, Hewish, M, Shackcloth, M.J, Robinson, L, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, McGranahan, N

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The evolution of lung cancer and impact of subclonal selection in TRACERx von Dietzen, M, Ward, S, Huebner, A, Bunkum, A, Hill, M.S, Grigoriadis, K, Moore, D.A, Liu, W.K, Pich, O, Salgado, R, Abbosh, C, Puttick, C, Lee, C, Middleton, G, Fennell, D.A, Russell, P, Lester, J.F, Papadatos-Pastos, D, Lawrence, D, Janes, S.M, Dive, C, Herrero, J, Quezada, S.A, Van Loo, P, Miedema, D.M, Nakas, A, Boyles, R, Rathinam, S, Wilson, C, Matharu, G, Primrose, L, Cheyne, H, Lacson, C, Shackleford, H, Djearaman, M, Kadiri, S, Leek, A, Totten, N, Fontaine, E, Granato, F, Rammohan, K, Joseph, L, Bishop, P, Crosbie, P, Brown, K, Priest, L, Lindsay, C.R, Kerr, A, Rothwell, D.G, Kaufmann, T.L, Sokac, M, Diossy, M, Stewart, A, Magness, A, Karamani, A, Chain, B, Campbell, B.B, Weeden, C.E, Karagianni, D, Kassiotis, G, Mastrokalos, G, Matos, I, Hartley, J.A, Enfield, K.S.S, Dijkstra, K, Vasquez, M, Litovchenko, M, Werner Sunderland, M, Tanić, M, Stone, R.K, Beck, S, Bola, S.K, Barbè, V, Lu, W.-T, Veiga, C, Clark, T, Procter, A.J, Martinoni Hoogenboom, E, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Gorman, P, Bandula, S, Sharp, A, Smith, S, Dhanda, H.K, Leslie, R, MacKenzie, M, Scarlett, L, Jordan, S, Bhayani, H, Ambrose, L, Kaniu, D, Malima, M, Dick, C, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M

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A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer von Wu, Y, Boeing, S, Czyzewska-Khan, J, Georgiou, A, Al-Bakir, M, Kerr, K, Cheyne, H, Aerts, H, Hewish, M, Khan, S, Sheaff, M, Kaufmann, T.L, Shaw, J, Primrose, L, Smith, S, Litchfield, K, Clipson, A, Dive, C, Rothwell, D, Kilgour, E, Carter, M, Lindsay, C.R, Skrzypski, M, Salgado, R, Diossy, M, Asif, M, Thomas, M, Wilcox, M, Nakas, A, Rathinam, S, Chowdhry, M.F, Leek, A, Blyth, K.G, Dick, C, De Sousa, P, Bhayani, H, Ambrose, L, Kaniu, D, Booth, S, Danson, S, Kibutu, F, Taylor, F, Lester, J, Stewart, A, Rowan, A, Denner, T, Greco, M, Puttick, C, Colliver, E, Dijkstra, K, Barbè, V, Demeulemeester, J, Castignani, C, Fu, H, Robinson, L, Papadatos-Pastos, D, Lock, S, Gilbert, K, Ashford, P, Pich, O, Ward, S, Frankell, A.M, Hartley, J.A, Lowe, H, Ensell, L, Karamani, A, Beck, S, Dietzen, M, Black, J.R.M, Ruiz, C.M, Bentham, R, Zhai, H, Matos, I.G, Shah, M, Cancino, F.G, Laycock, J, Magno, N, Lucas, O, Hill, M.S, Gamble, S, Borg, E, Stephens, R.C.M, Bandula, S, Duran, V, Litovchenko, M, Vanloo, S, Pawlik, P, Kadiri, S, Djearaman, M, Osman, A, Chee, S, Alzetani, A, Marrone, D, Dulloo, S, Califano, R, Krysiak, P, Rammohan, K, Novasio, J, McGranahan, N, Hayday, A.C

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Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution von McGranahan, N, Rosenthal, R, Hiley, C.T, Rowan, A.J, Watkins, T.B.K, Wilson, G.A, Birkbak, N.J, Veeriah, S, Van Loo, P, Herrero, J, Swanton, C, Jamal-Hanjani, M, Shafi, S, Czyzewska-Khan, J, Johnson, D, Laycock, J, Bosshard-Carter, L, Gorman, P, Hynds, R.E, Wilson, G, Horswell, S, Mitter, R, Escudero, M, Stewart, A, Rowan, A, Xu, H, Turajlic, S, Hiley, C, Abbosh, C, Goldman, J, Stone, R.K, Denner, T, Matthews, N, Elgar, G, Ward, S, Costa, M, Begum, S, Phillimore, B, Chambers, T, Nye, E, Graca, S, Al Bakir, M, Joshi, K, Furness, A, Ben Aissa, A, Wong, Y.N.S, Georgiou, A, Quezada, S, Hartley, J.A, Lowe, H.L, Lawrence, D, Hayward, M, Panagiotopoulos, N, Kolvekar, S, Falzon, M, Borg, E, Marafioti, T, Simeon, C, Hector, G, Smith, A, Aranda, M, Novelli, M, Oukrif, D, Janes, S.M, Thakrar, R, Forster, M, Ahmad, T, Lee, S.M, Papadatos-Pastos, D, Carnell, D, Mendes, R, George, J, Navani, N, Ahmed, A, Taylor, M, Choudhary, J, Summers, Y, Califano, R, Taylor, P, Shah, R, Krysiak, P, Rammohan, K, Fontaine, E, Booton, R, Evison, M, Crosbie, P, Moss, S, the TRACERx Consortium

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