High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities von Wink, Steven, Hiemstra, Steven, Herpers, Bram, van de Water, Bob

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A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration von Yizhak, Keren, Le Dévédec, Sylvia E, Rogkoti, Vasiliki Maria, Baenke, Franziska, de Boer, Vincent C, Frezza, Christian, Schulze, Almut, van de Water, Bob, Ruppin, Eytan

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Comparing in vitro human liver models to in vivo human liver using RNA-Seq von Gupta, Rajinder, Schrooders, Yannick, Hauser, Duncan, van Herwijnen, Marcel, Albrecht, Wiebke, ter Braak, Bas, Brecklinghaus, Tim, Castell, Jose V., Elenschneider, Leroy, Escher, Sylvia, Guye, Patrick, Hengstler, Jan G., Ghallab, Ahmed, Hansen, Tanja, Leist, Marcel, Maclennan, Richard, Moritz, Wolfgang, Tolosa, Laia, Tricot, Tine, Verfaillie, Catherine, Walker, Paul, van de Water, Bob, Kleinjans, Jos, Caiment, Florian

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In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment von Llewellyn, Samantha V., Niemeijer, Marije, Nymark, Penny, Moné, Martijn J., Water, Bob, Conway, Gillian E., Jenkins, Gareth J. S., Doak, Shareen H.

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A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies von Ramaiahgari, Sreenivasa C., den Braver, Michiel W., Herpers, Bram, Terpstra, Valeska, Commandeur, Jan N. M., van de Water, Bob, Price, Leo S.

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Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer von Yizhak, Keren, Gaude, Edoardo, Le Dévédec, Sylvia, Waldman, Yedael Y, Stein, Gideon Y, van de Water, Bob, Frezza, Christian, Ruppin, Eytan

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Squaramide‐Based Supramolecular Materials Drive HepG2 Spheroid Differentiation von Liu, Tingxian, den Berk, Linda, Wondergem, Joeri A. J., Tong, Ciqing, Kwakernaak, Markus C., Braak, Bas ter, Heinrich, Doris, Water, Bob, Kieltyka, Roxanne E.

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Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression von He, Jichao, McLaughlin, Ronan P., van der Beek, Lambert, Canisius, Sander, Wessels, Lodewyk, Smid, Marcel, Martens, John W. M., Foekens, John A., Zhang, Yinghui, van de Water, Bob

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Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy von Koedoot, Esmee, Wolters, Liesanne, Smid, Marcel, Stoilov, Peter, Burger, Gerhard A., Herpers, Bram, Yan, Kuan, Price, Leo S., Martens, John W. M., Le Dévédec, Sylvia E., van de Water, Bob

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Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment von Wink, Steven, Hiemstra, Steven, Huppelschoten, Suzanna, Danen, Erik, Niemeijer, Marije, Hendriks, Giel, Vrieling, Harry, Herpers, Bram, van de Water, Bob

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Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity von Herpers, Bram, Wink, Steven, Fredriksson, Lisa, Di, Zi, Hendriks, Giel, Vrieling, Harry, de Bont, Hans, van de Water, Bob

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Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure von Hiemstra, Steven, Fehling-Kaschek, Mirjam, Kuijper, Isoude A., Bischoff, Luc J. M., Wijaya, Lukas S., Rosenblatt, Marcus, Esselink, Jeroen, van Egmond, Allard, Mos, Jornt, Beltman, Joost B., Timmer, Jens, van de Water, Bob, Kaschek, Daniel

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Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals von van der Stel, Wanda, Carta, Giada, Eakins, Julie, Darici, Salihanur, Delp, Johannes, Forsby, Anna, Bennekou, Susanne Hougaard, Gardner, Iain, Leist, Marcel, Danen, Erik H. J., Walker, Paul, van de Water, Bob, Jennings, Paul

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Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity von Fredriksson, Lisa, Wink, Steven, Herpers, Bram, Benedetti, Giulia, Hadi, Mackenzie, de Bont, Hans, Groothuis, Geny, Luijten, Mirjam, Danen, Erik, de Graauw, Marjo, Meerman, John, van de Water, Bob

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A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and ace... von Driessen, Marja, Vitins, Alexa P., Pennings, Jeroen L.A., Kienhuis, Anne S., Water, Bob van de, van der Ven, Leo T.M.

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The integrated stress response‐related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability von Vlasveld, Matthijs, Callegaro, Giulia, Fisher, Ciarán, Eakins, Julie, Walker, Paul, Lok, Samantha, Oost, Siddh, Jong, Brechtje, Pellegrino‐Coppola, Damiano, Burger, Gerhard, Wink, Steven, Water, Bob

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Splicing regulatory factors in breast cancer hallmarks and disease progression von Koedoot, Esmee, Wolters, Liesanne, Water, Bob van de, Dévédec, Sylvia E. Le

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Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival von Nair, Nishanth Ulhas, Das, Avinash, Rogkoti, Vasiliki-Maria, Fokkelman, Michiel, Marcotte, Richard, de Jong, Chiaro G., Koedoot, Esmee, Lee, Joo Sang, Meilijson, Isaac, Hannenhalli, Sridhar, Neel, Benjamin G., de Water, Bob van, Le Dévédec, Sylvia E., Ruppin, Eytan

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Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors von Delp, Johannes, Cediel-Ulloa, Andrea, Suciu, Ilinca, Kranaster, Petra, van Vugt-Lussenburg, Barbara MA, Munic Kos, Vesna, van der Stel, Wanda, Carta, Giada, Bennekou, Susanne Hougaard, Jennings, Paul, van de Water, Bob, Forsby, Anna, Leist, Marcel

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Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells von Béquignon, Olivier J. M., Gómez-Tamayo, Jose C., Lenselink, Eelke B., Wink, Steven, Hiemstra, Steven, Lam, Chi Chung, Gadaleta, Domenico, Roncaglioni, Alessandra, Norinder, Ulf, Water, Bob van de, Pastor, Manuel, van Westen, Gerard J. P.

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