Patterned Deposition of Cells and Proteins onto Surfaces by Using Three-Dimensional Microfluidic Systems von Chiu, D T, Jeon, N L, Huang, S, Kane, R S, Wargo, C J, Choi, I S, Ingber, D E, Whitesides, G M

Volltext

Design and Fabrication of Integrated Passive Valves and Pumps for Flexible Polymer 3-Dimensional Microfluidic Systems von Jeon, N L, Chiu, D T, Wargo, C J, Wu, Hongkai, Choi, I S, Anderson, J R, Whitesides, G M

Volltext

Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies von Wei, Spencer C., Anang, Nana-Ama A. S., Sharma, Roshan, Andrews, Miles C., Reuben, Alexandre, Levine, Jacob H., Cogdill, Alexandria P., Mancuso, James J., Wargo, Jennifer A., Pe’er, Dana, Allison, James P.

Volltext

Pathological assessment of resection specimens after neoadjuvant therapy for metastatic melanoma von Tetzlaff, M.T., Messina, J.L., Stein, J.E., Xu, X., Amaria, R.N., Blank, C.U., van de Wiel, B.A., Ferguson, P.M., Rawson, R.V., Ross, M.I., Spillane, A.J., Gershenwald, J.E., Saw, R.P.M., van Akkooi, A.C.J., van Houdt, W.J., Mitchell, T.C., Menzies, A.M., Long, G.V., Wargo, J.A., Davies, M.A., Prieto, V.G., Taube, J.M., Scolyer, R.A.

Volltext

Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC) von Menzies, Alexander M., Amaria, Rodabe N., Rozeman, Elisa A., Huang, Alexander C., Tetzlaff, Michael T., van de Wiel, Bart A., Lo, Serigne, Tarhini, Ahmad A., Burton, Elizabeth M., Pennington, Thomas E., Saw, Robyn P. M., Xu, Xiaowei, Karakousis, Giorgos C., Ascierto, Paolo A., Spillane, Andrew J., van Akkooi, Alexander C. J., Davies, Michael A., Mitchell, Tara C., Tawbi, Hussein A., Scolyer, Richard A., Wargo, Jennifer A., Blank, Christian U., Long, Georgina V.

Volltext

Cancer Evolution during Immunotherapy von Andrews, M.C., Wargo, J.A.

Volltext

Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells von Goyal, Yogesh, Busch, Gianna T., Pillai, Maalavika, Li, Jingxin, Boe, Ryan H., Grody, Emanuelle I., Chelvanambi, Manoj, Dardani, Ian P., Emert, Benjamin, Bodkin, Nicholas, Braun, Jonas, Fingerman, Dylan, Kaur, Amanpreet, Jain, Naveen, Ravindran, Pavithran T., Mellis, Ian A., Kiani, Karun, Alicea, Gretchen M., Fane, Mitchell E., Ahmed, Syeda Subia, Li, Haiyin, Chen, Yeqing, Chai, Cedric, Kaster, Jessica, Witt, Russell G., Lazcano, Rossana, Ingram, Davis R., Johnson, Sarah B., Wani, Khalida, Dunagin, Margaret C., Lazar, Alexander J., Weeraratna, Ashani T., Wargo, Jennifer A., Herlyn, Meenhard, Raj, Arjun

Volltext

Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial von Cascone, Tina, William, William N., Weissferdt, Annikka, Leung, Cheuk H., Lin, Heather Y., Pataer, Apar, Godoy, Myrna C. B., Carter, Brett W., Federico, Lorenzo, Reuben, Alexandre, Khan, Md Abdul Wadud, Dejima, Hitoshi, Francisco-Cruz, Alejandro, Parra, Edwin R., Solis, Luisa M., Fujimoto, Junya, Tran, Hai T., Kalhor, Neda, Fossella, Frank V., Mott, Frank E., Tsao, Anne S., Blumenschein, George, Le, Xiuning, Zhang, Jianjun, Skoulidis, Ferdinandos, Kurie, Jonathan M., Altan, Mehmet, Lu, Charles, Glisson, Bonnie S., Byers, Lauren Averett, Elamin, Yasir Y., Mehran, Reza J., Rice, David C., Walsh, Garrett L., Hofstetter, Wayne L., Roth, Jack A., Antonoff, Mara B., Kadara, Humam, Haymaker, Cara, Bernatchez, Chantale, Ajami, Nadim J., Jenq, Robert R., Sharma, Padmanee, Allison, James P., Futreal, Andrew, Wargo, Jennifer A., Wistuba, Ignacio I., Swisher, Stephen G., Lee, J. Jack, Gibbons, Don L., Vaporciyan, Ara A., Heymach, John V., Sepesi, Boris

Volltext

A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors von Konieczkowski, David J, Johannessen, Cory M, Abudayyeh, Omar, Kim, Jong Wook, Cooper, Zachary A, Piris, Adriano, Frederick, Dennie T, Barzily-Rokni, Michal, Straussman, Ravid, Haq, Rizwan, Fisher, David E, Mesirov, Jill P, Hahn, William C, Flaherty, Keith T, Wargo, Jennifer A, Tamayo, Pablo, Garraway, Levi A

Volltext

Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome von Simpson, Rebecca C., Shanahan, Erin R., Batten, Marcel, Reijers, Irene L. M., Read, Mark, Silva, Ines P., Versluis, Judith M., Ribeiro, Rosilene, Angelatos, Alexandra S., Tan, Jian, Adhikari, Chandra, Menzies, Alexander M., Saw, Robyn P. M., Gonzalez, Maria, Shannon, Kerwin F., Spillane, Andrew J., Velickovic, Rebecca, Lazar, Alexander J., Damania, Ashish V., Mishra, Aditya K., Chelvanambi, Manoj, Banerjee, Anik, Ajami, Nadim J., Wargo, Jennifer A., Macia, Laurence, Holmes, Andrew J., Wilmott, James S., Blank, Christian U., Scolyer, Richard A., Long, Georgina V.

Volltext

Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma von Amaria, Rodabe N., Reddy, Sangeetha M., Tawbi, Hussein A., Davies, Michael A., Ross, Merrick I., Glitza, Isabella C., Cormier, Janice N., Lewis, Carol, Hwu, Wen-Jen, Hanna, Ehab, Diab, Adi, Wong, Michael K., Royal, Richard, Gross, Neil, Weber, Randal, Lai, Stephen Y., Ehlers, Richard, Blando, Jorge, Milton, Denái R., Woodman, Scott, Kageyama, Robin, Wells, Daniel K., Hwu, Patrick, Patel, Sapna P., Lucci, Anthony, Hessel, Amy, Lee, Jeffrey E., Gershenwald, Jeffrey, Simpson, Lauren, Burton, Elizabeth M., Posada, Liberty, Haydu, Lauren, Wang, Linghua, Zhang, Shaojun, Lazar, Alexander J., Hudgens, Courtney W., Gopalakrishnan, Vancheswaran, Reuben, Alexandre, Andrews, Miles C., Spencer, Christine N., Prieto, Victor, Sharma, Padmanee, Allison, James, Tetzlaff, Michael T., Wargo, Jennifer A.

Volltext

Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial von Cascone, Tina, Leung, Cheuk H., Weissferdt, Annikka, Pataer, Apar, Carter, Brett W., Godoy, Myrna C. B., Feldman, Hope, William, William N., Xi, Yuanxin, Basu, Sreyashi, Sun, Jing Jing, Yadav, Shalini S., Rojas Alvarez, Frank R., Lee, Younghee, Mishra, Aditya K., Chen, Lili, Pradhan, Monika, Guo, Haiping, Sinjab, Ansam, Zhou, Nicolas, Negrao, Marcelo V., Le, Xiuning, Gay, Carl M., Tsao, Anne S., Byers, Lauren Averett, Altan, Mehmet, Glisson, Bonnie S., Fossella, Frank V., Elamin, Yasir Y., Blumenschein, George, Zhang, Jianjun, Skoulidis, Ferdinandos, Wu, Jia, Mehran, Reza J., Rice, David C., Walsh, Garrett L., Hofstetter, Wayne L., Rajaram, Ravi, Antonoff, Mara B., Fujimoto, Junya, Solis, Luisa M., Parra, Edwin R., Haymaker, Cara, Wistuba, Ignacio I., Swisher, Stephen G., Vaporciyan, Ara A., Lin, Heather Y., Wang, Jing, Gibbons, Don L., Jack Lee, J., Ajami, Nadim J., Wargo, Jennifer A., Allison, James P., Sharma, Padmanee, Kadara, Humam, Heymach, John V., Sepesi, Boris

Volltext

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases von Fischer, Grant M, Jalali, Ali, Kircher, David A, Lee, Won-Chul, McQuade, Jennifer L, Haydu, Lauren E, Joon, Aron Y, Reuben, Alexandre, de Macedo, Mariana P, Carapeto, Fernando C L, Yang, Chendong, Srivastava, Anuj, Ambati, Chandrashekar R, Sreekumar, Arun, Hudgens, Courtney W, Knighton, Barbara, Deng, Wanleng, Ferguson, Sherise D, Tawbi, Hussein A, Glitza, Isabella C, Gershenwald, Jeffrey E, Vashisht Gopal, Y N, Hwu, Patrick, Huse, Jason T, Wargo, Jennifer A, Futreal, P Andrew, Putluri, Nagireddy, Lazar, Alexander J, DeBerardinis, Ralph J, Marszalek, Joseph R, Zhang, Jianjun, Holmen, Sheri L, Tetzlaff, Michael T, Davies, Michael A

Volltext

Implementation of a Pan-Genomic Approach to Investigate Holobiont-Infecting Microbe Interaction: A Case Report of a Leukemic Patient with Invasive Mucormycosis von Shelburne, Samuel A, Ajami, Nadim J, Chibucos, Marcus C, Beird, Hannah C, Tarrand, Jeffrey, Galloway-Peña, Jessica, Albert, Nathan, Chemaly, Roy F, Ghantoji, Shashank S, Marsh, Lisa, Pemmaraju, Naveen, Andreeff, Michael, Shpall, Elizabeth J, Wargo, Jennifer A, Rezvani, Katayoun, Alousi, Amin, Bruno, Vincent M, Futreal, Phillip A, Petrosino, Joseph F, Kontoyiannis, Dimitrios P

Volltext

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy von Peng, Weiyi, Chen, Jie Qing, Liu, Chengwen, Malu, Shruti, Creasy, Caitlin, Tetzlaff, Michael T, Xu, Chunyu, McKenzie, Jodi A, Zhang, Chunlei, Liang, Xiaoxuan, Williams, Leila J, Deng, Wanleng, Chen, Guo, Mbofung, Rina, Lazar, Alexander J, Torres-Cabala, Carlos A, Cooper, Zachary A, Chen, Pei-Ling, Tieu, Trang N, Spranger, Stefani, Yu, Xiaoxing, Bernatchez, Chantale, Forget, Marie-Andree, Haymaker, Cara, Amaria, Rodabe, McQuade, Jennifer L, Glitza, Isabella C, Cascone, Tina, Li, Haiyan S, Kwong, Lawrence N, Heffernan, Timothy P, Hu, Jianhua, Bassett, Jr, Roland L, Bosenberg, Marcus W, Woodman, Scott E, Overwijk, Willem W, Lizée, Gregory, Roszik, Jason, Gajewski, Thomas F, Wargo, Jennifer A, Gershenwald, Jeffrey E, Radvanyi, Laszlo, Davies, Michael A, Hwu, Patrick

Volltext

Histopathological features of complete pathological response predict recurrence-free survival following neoadjuvant targeted therapy for metastatic melanoma von Tetzlaff, M.T., Adhikari, C., Lo, S., Rawson, R.V., Amaria, R.N., Menzies, A.M., Wilmott, J.S., Ferguson, P.M., Ross, M.I., Spillane, A.J., Vu, K.A., Ma, J., Ning, J., Haydu, L.E., Saw, R.P.M., Wargo, J.A., Tawbi, H.A., Gershenwald, J.E., Long, G.V., Davies, M.A., Scolyer, R.A.

Volltext

Efficacy of immune checkpoint inhibitors for the treatment of advanced melanoma in patients with concomitant chronic lymphocytic leukemia von Cass, S.H., Tobin, J.W.D., Seo, Y.D., Gener-Ricos, G., Keung, E.Z., Burton, E.M., Davies, M.A., McQuade, J.L., Lazar, A.J., Mason, R., Millward, M., Sandhu, S., Khoo, C., Warburton, L., Guerra, V., Haydon, A., Dearden, H., Menzies, A.M., Carlino, M., Smith, J.L., Mollee, P., Burgess, M., Mapp, S., Keane, C., Atkinson, V., Parikh, S.A., Markovic, S.N., Ding, W., Call, T.G., Hampel, P.J., Long, G.V., Wargo, J.A., Ferrajoli, A.

Volltext

Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics von Frederick, Dennie T, Salas Fragomeni, Roberto A, Schalck, Aislyn, Ferreiro-Neira, Isabel, Hoff, Taylor, Cooper, Zachary A, Haq, Rizwan, Panka, David J, Kwong, Lawrence N, Davies, Michael A, Cusack, James C, Flaherty, Keith T, Fisher, David E, Mier, James W, Wargo, Jennifer A, Sullivan, Ryan J

Volltext

The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression von Huang, Lu, Malu, Shruti, McKenzie, Jodi A, Andrews, Miles C, Talukder, Amjad H, Tieu, Trang, Karpinets, Tatiana, Haymaker, Cara, Forget, Marie-Andrée, Williams, Leila J, Wang, Zhe, Mbofung, Rina M, Wang, Zhi-Qiang, Davis, Richard Eric, Lo, Roger S, Wargo, Jennifer A, Davies, Michael A, Bernatchez, Chantale, Heffernan, Timothy, Amaria, Rodabe N, Korkut, Anil, Peng, Weiyi, Roszik, Jason, Lizée, Gregory, Woodman, Scott E, Hwu, Patrick

Volltext

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade von Chen, Pei-Ling, Roh, Whijae, Reuben, Alexandre, Cooper, Zachary A, Spencer, Christine N, Prieto, Peter A, Miller, John P, Bassett, Roland L, Gopalakrishnan, Vancheswaran, Wani, Khalida, De Macedo, Mariana Petaccia, Austin-Breneman, Jacob L, Jiang, Hong, Chang, Qing, Reddy, Sangeetha M, Chen, Wei-Shen, Tetzlaff, Michael T, Broaddus, Russell J, Davies, Michael A, Gershenwald, Jeffrey E, Haydu, Lauren, Lazar, Alexander J, Patel, Sapna P, Hwu, Patrick, Hwu, Wen-Jen, Diab, Adi, Glitza, Isabella C, Woodman, Scott E, Vence, Luis M, Wistuba, Ignacio I, Amaria, Rodabe N, Kwong, Lawrence N, Prieto, Victor, Davis, R Eric, Ma, Wencai, Overwijk, Willem W, Sharpe, Arlene H, Hu, Jianhua, Futreal, P Andrew, Blando, Jorge, Sharma, Padmanee, Allison, James P, Chin, Lynda, Wargo, Jennifer A

Volltext