Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production von Leoncikas, Vytautas, Wu, Huihai, Ward, Lara T., Kierzek, Andrzej M., Plant, Nick J.

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Biophysical Methods in Drug Discovery from Small Molecule to Pharmaceutical von Holdgate, Geoffrey, Geschwindner, Stefan, Breeze, Alex, Davies, Gareth, Colclough, Nicola, Temesi, David, Ward, Lara

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Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)‑4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3‑b]pyridazin-... von Bradbury, Robert H, Callis, Rowena, Carr, Gregory R, Chen, Huawei, Clark, Edwin, Feron, Lyman, Glossop, Steve, Graham, Mark A, Hattersley, Maureen, Jones, Chris, Lamont, Scott G, Ouvry, Gilles, Patel, Anil, Patel, Joe, Rabow, Alfred A, Roberts, Craig A, Stokes, Stephen, Stratton, Natalie, Walker, Graeme E, Ward, Lara, Whalley, David, Whittaker, David, Wrigley, Gail, Waring, Michael J

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Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase von Ducray, Richard, Simpson, Iain, Jung, Frederic H., Nissink, J. Willem M., Kenny, Peter W., Fitzek, Martina, Walker, Graeme E., Ward, Lara T., Hudson, Kevin

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MUFINS: multi-formalism interaction network simulator von Wu, Huihai, von Kamp, Axel, Leoncikas, Vytautas, Mori, Wataru, Sahin, Nilgun, Gevorgyan, Albert, Linley, Catherine, Grabowski, Marek, Mannan, Ahmad A, Stoy, Nicholas, Stewart, Graham R, Ward, Lara T, Lewis, David J M, Sroka, Jacek, Matsuno, Hiroshi, Klamt, Steffen, Westerhoff, Hans V, McFadden, Johnjoe, Plant, Nicholas J, Kierzek, Andrzej M

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P5 - Use of the HμREL® human hepatocyte co-culture model to determine intrinsic clearance and elucidate metabolic pathways of stable compounds von Butler, Philip, Wilcock, Jo, Ward, Lara, Paine, Katie, Vahmjanins, Marks, Kerins, Anna

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Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel von Hancox, Urs, Cosulich, Sabina, Hanson, Lyndsey, Trigwell, Cath, Lenaghan, Carol, Ellston, Rebecca, Dry, Hannah, Crafter, Claire, Barlaam, Bernard, Fitzek, Martina, Smith, Paul D, Ogilvie, Donald, D'Cruz, Celina, Castriotta, Lillian, Wedge, Stephen R, Ward, Lara, Powell, Steve, Lawson, Mandy, Davies, Barry R, Harrington, Elizabeth A, Foster, Emily, Cumberbatch, Marie, Green, Stephen, Barry, Simon T

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Discovery of ( R )-8-(1-(3,5-Difluorophenylamino)ethyl)- N , N -dimethyl-2-morpholino-4-oxo-4 H -chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3... von Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Pasquet, Marie-Jeanne, Péru, Aurélien, Plé, Patrick, Saleh, Twana, Vautier, Michel, Walker, Mike, Ward, Lara, Warin, Nicolas

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Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers von Hudson, Kevin, Hancox, Urs J, Trigwell, Cath, McEwen, Robert, Polanska, Urszula M, Nikolaou, Myria, Morentin Gutierrez, Pablo, Avivar-Valderas, Alvaro, Delpuech, Oona, Dudley, Phillippa, Hanson, Lyndsey, Ellston, Rebecca, Jones, Alys, Cumberbatch, Marie, Cosulich, Sabina C, Ward, Lara, Cruzalegui, Francisco, Green, Stephen

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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective... von Barlaam, Bernard, Cosulich, Sabina, Delouvrié, Bénédicte, Ellston, Rebecca, Fitzek, Martina, Germain, Hervé, Green, Stephen, Hancox, Urs, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Lebraud, Honorine, Magnien, Françoise, Lamorlette, Maryannick, Le Griffon, Antoine, Morgentin, Rémy, Ouvry, Gilles, Page, Ken, Pasquet, Georges, Polanska, Urszula, Ruston, Linette, Saleh, Twana, Vautier, Michel, Ward, Lara

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Abstract 2668: Applying mechanistic PK/PD modeling to describe the efficacy of AZD8835 (PI3Kalpha/delta inhibitor) in a mouse xenograft breast tumor model at different dosing sched... von Morentin Gutierrez, Pablo, Hudson, Kevin, Hancox, Urs J., Ward, Lara T., Polanska, Urszula M., Cumberbatch, Marie, Cruzalegui, Francisco H.

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Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours von Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Giordanetto, Fabrizio, Green, Stephen, Inghardt, Tord, Hennequin, Laurent, Hancox, Urs, Lambert-van der Brempt, Christine, Morgentin, Rémy, Pass, Sarah, Plé, Patrick, Saleh, Twana, Ward, Lara

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Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors von Barlaam, Bernard, Cosulich, Sabina, Fitzek, Martina, Germain, Hervé, Green, Stephen, Hanson, Lyndsey L., Harris, Craig S., Hancox, Urs, Hudson, Kevin, Lambert-van der Brempt, Christine, Lamorlette, Maryannick, Magnien, Françoise, Ouvry, Gilles, Page, Ken, Ruston, Linette, Ward, Lara, Delouvrié, Bénédicte

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Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold von Barlaam, Bernard, Cosulich, Sabina, Fitzek, Martina, Green, Stephen, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Ouvry, Gilles, Page, Ken, Ruston, Linette, Ward, Lara, Delouvrié, Bénédicte

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Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours von Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Ellston, Rebecca, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Plé, Patrick, Ward, Lara, Warin, Nicolas

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Abstract A24: Comprehensive PI3K pathway inhibition through combination of the PI3Kβ/δ inhibitor AZD8186 and the mTORC1/2 inhibitor AZD2014 drives tumor regression in vivo von Hancox, Urs, Polanska, Urszula, Hanson, Lyndsay, Ellston, Rebecca, Maynard, Julia, Kraus, Manfred, Curwen, jon, Klinowska, Teresa, Ward, Lara, Cruzalegui, Francisco, Green, Stephen, Symeonides, Stefan, Cronin, Kathryn, Barry, Simon

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Abstract 4249: The Pi3Kβ/δ inhibitor AZD8186 has potential to treat tumours in combination with key signalling pathway inhibitors von Barry, Simon T., Cronin, Kathryn, Cumberbatch, Marie, Ellston, Rebecca, Foster, Emily, Hancox, Urs, Hanson, Lyndsey, Harrington, Liz, Lenaghan, Carol, Symeonides, Stefan, Trigwell, Cath, Ward, Lara

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Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours von Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Péru, Aurélien, Plé, Patrick, Saleh, Twana, Ward, Lara, Warin, Nicolas

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Abstract 2665: High dose intermittent scheduling of AZD8835, a novel potent and selective inhibitor of PI3Kα and PI3Kδ, identifies potential treatment strategies for PIK3CA-depende... von Hudson, Kevin, Hancox, Urs, Trigwell, Cath, Dudley, Phillippa, Hanson, Lyndsey, McEwen, Robert, Jones, Alys, Cumberbatch, Marie, Polanska, Urszula, Ellston, Rebecca, Delpuech, Oona, Morentin Gutierrez, Pablo, Ward, Lara, Cruzalegui, Francisco, Green, Stephen

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Abstract 4696: Combining AZD8186, an inhibitor of PI3Kbeta, with inhibitors of PI3Kalpha and mTORC1/2 gives comprehensive pathway suppression and enhanced antitumor activity in PTE... von Hancox, Urs, Polanska, Urszula, Lynch, James T., Lenaghan, Carol, Trigwell, Cath, Depuelch, Oona, Dudley, Phillippa, Maynard, Juliana, Ward, Lara, Hudson, Kevin, Curwen, Jon, Cruzalegui, Francisco, Green, Stephen, Teresa, Klinowska, Barry, Simon T.

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