EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity von Bieschke, Jan, Russ, Jenny, Friedrich, Ralf P, Ehrnhoefer, Dagmar E, Wobst, Heike, Neugebauer, Katja, Wanker, Erich E

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HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration von Mielcarek, Michal, Landles, Christian, Weiss, Andreas, Bradaia, Amyaouch, Seredenina, Tamara, Inuabasi, Linda, Osborne, Georgina F, Wadel, Kristian, Touller, Chrystelle, Butler, Rachel, Robertson, Janette, Franklin, Sophie A, Smith, Donna L, Park, Larry, Marks, Paul A, Wanker, Erich E, Olson, Eric N, Luthi-Carter, Ruth, van der Putten, Herman, Beaumont, Vahri, Bates, Gillian P

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HIPPIE: Integrating protein interaction networks with experiment based quality scores von Schaefer, Martin H, Fontaine, Jean-Fred, Vinayagam, Arunachalam, Porras, Pablo, Wanker, Erich E, Andrade-Navarro, Miguel A

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The hunt for huntingtin function: interaction partners tell many different stories von Harjes, Phoebe, Wanker, Erich E

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Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation von Waelter, S, Boeddrich, A, Lurz, R, Scherzinger, E, Lueder, G, Lehrach, H, Wanker, E E

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Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex von Scior, Annika, Buntru, Alexander, Arnsburg, Kristin, Ast, Anne, Iburg, Manuel, Juenemann, Katrin, Pigazzini, Maria Lucia, Mlody, Barbara, Puchkov, Dmytro, Priller, Josef, Wanker, Erich E, Prigione, Alessandro, Kirstein, Janine

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The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules von Kunde, S.A., Musante, L., Grimme, A., Fischer, U., Müller, E., Wanker, E.E., Kalscheuer, V.M.

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Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks von Schaefer, Martin H, Wanker, Erich E, Andrade-Navarro, Miguel A

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A directed protein interaction network for investigating intracellular signal transduction von Vinayagam, Arunachalam, Stelzl, Ulrich, Foulle, Raphaele, Plassmann, Stephanie, Zenkner, Martina, Timm, Jan, Assmus, Heike E, Andrade-Navarro, Miguel A, Wanker, Erich E

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A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome von Stelzl, Ulrich, Worm, Uwe, Lalowski, Maciej, Haenig, Christian, Brembeck, Felix H., Goehler, Heike, Stroedicke, Martin, Zenkner, Martina, Schoenherr, Anke, Koeppen, Susanne, Timm, Jan, Mintzlaff, Sascha, Abraham, Claudia, Bock, Nicole, Kietzmann, Silvia, Goedde, Astrid, Toksöz, Engin, Droege, Anja, Krobitsch, Sylvia, Korn, Bernhard, Birchmeier, Walter, Lehrach, Hans, Wanker, Erich E.

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Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders von Lorenz, Carmen, Lesimple, Pierre, Bukowiecki, Raul, Zink, Annika, Inak, Gizem, Mlody, Barbara, Singh, Manvendra, Semtner, Marcus, Mah, Nancy, Auré, Karine, Leong, Megan, Zabiegalov, Oleksandr, Lyras, Ekaterini-Maria, Pfiffer, Vanessa, Fauler, Beatrix, Eichhorst, Jenny, Wiesner, Burkhard, Huebner, Norbert, Priller, Josef, Mielke, Thorsten, Meierhofer, David, Izsvák, Zsuzsanna, Meier, Jochen C., Bouillaud, Frédéric, Adjaye, James, Schuelke, Markus, Wanker, Erich E., Lombès, Anne, Prigione, Alessandro

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The polyphenol EGCG directly targets intracellular amyloid‐β aggregates and promotes their lysosomal degradation von Secker, Christopher, Motzny, Angelika Y., Kostova, Simona, Buntru, Alexander, Helmecke, Lucas, Reus, Laura, Steinfort, Robert, Brusendorf, Lydia, Boeddrich, Annett, Neuendorf, Nancy, Diez, Lisa, Schmieder, Peter, Schulz, Aline, Czekelius, Constantin, Wanker, Erich E.

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An empirical framework for binary interactome mapping von Tavernier, Jan, Wanker, Erich E, Barabási, Albert-László, Vidal, Marc, Venkatesan, Kavitha, Rual, Jean-François, Vazquez, Alexei, Stelzl, Ulrich, Lemmens, Irma, Hirozane-Kishikawa, Tomoko, Hao, Tong, Zenkner, Martina, Xin, Xiaofeng, Goh, Kwang-Il, Yildirim, Muhammed A, Simonis, Nicolas, Heinzmann, Kathrin, Gebreab, Fana, Sahalie, Julie M, Cevik, Sebiha, Simon, Christophe, de Smet, Anne-Sophie, Dann, Elizabeth, Smolyar, Alex, Vinayagam, Arunachalam, Yu, Haiyuan, Szeto, David, Borick, Heather, Dricot, Amélie, Klitgord, Niels, Murray, Ryan R, Lin, Chenwei, Lalowski, Maciej, Timm, Jan, Rau, Kirstin, Boone, Charles, Braun, Pascal, Cusick, Michael E, Roth, Frederick P, Hill, David E

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A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease von Boeddrich, Annett, Haenig, Christian, Neuendorf, Nancy, Blanc, Eric, Ivanov, Andranik, Kirchner, Marieluise, Schleumann, Philipp, Bayraktaroğlu, Irem, Richter, Matthias, Molenda, Christine Mirjam, Sporbert, Anje, Zenkner, Martina, Schnoegl, Sigrid, Suenkel, Christin, Schneider, Luisa-Sophie, Rybak-Wolf, Agnieszka, Kochnowsky, Bianca, Byrne, Lauren M, Wild, Edward J, Nielsen, Jørgen E, Dittmar, Gunnar, Peters, Oliver, Beule, Dieter, Wanker, Erich E

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Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains von Haenig, Christian, Atias, Nir, Taylor, Alexander K., Mazza, Arnon, Schaefer, Martin H., Russ, Jenny, Riechers, Sean-Patrick, Jain, Shushant, Coughlin, Maura, Fontaine, Jean-Fred, Freibaum, Brian D., Brusendorf, Lydia, Zenkner, Martina, Porras, Pablo, Stroedicke, Martin, Schnoegl, Sigrid, Arnsburg, Kristin, Boeddrich, Annett, Pigazzini, Lucia, Heutink, Peter, Taylor, J. Paul, Kirstein, Janine, Andrade-Navarro, Miguel A., Sharan, Roded, Wanker, Erich E.

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Maximizing binary interactome mapping with a minimal number of assays von Choi, Soon Gang, Olivet, Julien, Cassonnet, Patricia, Vidalain, Pierre-Olivier, Luck, Katja, Lambourne, Luke, Spirohn, Kerstin, Lemmens, Irma, Dos Santos, Mélanie, Demeret, Caroline, Jones, Louis, Rangarajan, Sudharshan, Bian, Wenting, Coutant, Eloi P., Janin, Yves L., van der Werf, Sylvie, Trepte, Philipp, Wanker, Erich E., De Las Rivas, Javier, Tavernier, Jan, Twizere, Jean-Claude, Hao, Tong, Hill, David E., Vidal, Marc, Calderwood, Michael A., Jacob, Yves

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Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions von Wallach, Thomas, Schellenberg, Katja, Maier, Bert, Kalathur, Ravi Kiran Reddy, Porras, Pablo, Wanker, Erich E, Futschik, Matthias E, Kramer, Achim

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The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes von Rodriguez Camargo, Diana C., Tripsianes, Konstantinos, Buday, Katalin, Franko, Andras, Göbl, Christoph, Hartlmüller, Christoph, Sarkar, Riddhiman, Aichler, Michaela, Mettenleiter, Gabriele, Schulz, Michael, Böddrich, Annett, Erck, Christian, Martens, Henrik, Walch, Axel Karl, Madl, Tobias, Wanker, Erich E., Conrad, Marcus, de Angelis, Martin Hrabě, Reif, Bernd

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A Potent Small Molecule Inhibits Polyglutamine Aggregation in Huntington's Disease Neurons and Suppresses Neurodegeneration in vivo von Zhang, Xiaoqian, Smith, Donna L., Meriin, Anatoli B., Engemann, Sabine, Russel, Deborah E., Roark, Margo, Washington, Shetia L., Maxwell, Michele M., Marsh, J. Lawrence, Thompson, Leslie Michels, Wanker, Erich E., Young, Anne B., Housman, David E., Bates, Gillian P., Sherman, Michael Y., Kazantsev, Aleksey G.

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Plant nitric oxide synthase: a never-ending story? von Zemojtel, Tomasz, Fröhlich, Andreas, Palmieri, M. Cristina, Kolanczyk, Mateusz, Mikula, Ivan, Wyrwicz, Lucjan S., Wanker, Erich E., Mundlos, Stefan, Vingron, Martin, Martasek, Pavel, Durner, Jörg

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