Considerations regarding the use of nonhuman primates in assessing safety endpoints for pharmaceuticals von Brown, Paul C., Wange, Ronald L.

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3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration von Wang, Hongbing, Brown, Paul C., Chow, Edwin C.Y., Ewart, Lorna, Ferguson, Stephen S., Fitzpatrick, Suzanne, Freedman, Benjamin S., Guo, Grace L., Hedrich, William, Heyward, Scott, Hickman, James, Isoherranen, Nina, Li, Albert P., Liu, Qi, Mumenthaler, Shannon M., Polli, James, Proctor, William R., Ribeiro, Alexandre, Wang, Jian‐Ying, Wange, Ronald L., Huang, Shiew‐Mei

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FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations von Ackley, David, Birkebak, Joanne, Blumel, Jorg, Bourcier, Todd, de Zafra, Christina, Goodwin, Andrew, Halpern, Wendy, Herzyk, Danuta, Kronenberg, Sven, Mauthe, Robert, Shenton, Jacintha, Shuey, Dana, Wange, Ronald L.

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Implementation of the principles of the 3Rs of animal testing at CDER: Past, present and future von Wange, Ronald L., Brown, Paul C., Davis-Bruno, Karen L.

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An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs) von Avila, Amy M., Bebenek, Ilona, Bonzo, Jessica A., Bourcier, Todd, Davis Bruno, Karen L., Carlson, David B., Dubinion, John, Elayan, Ikram, Harrouk, Wafa, Lee, Shwu-Luan, Mendrick, Donna L., Merrill, Jill C., Peretz, Jackye, Place, Emily, Saulnier, Muriel, Wange, Ronald L., Yao, Jia, Zhao, Dong, Brown, Paul C.

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Exploring rabbit as a nonrodent species for general toxicology studies von Sokolowski, Katie, Turner, Patricia V, Lewis, Elise, Wange, Ronald L, Fortin, Marie C

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Weight of Evidence: Is an Animal Study Warranted? Assessments for Carcinogenicity, Drug Abuse Liability, and Pediatric Safety von Ramani, Thulasi, Wange, Ronald L., Manetz, T. Scott, Kruzich, Paul J., Laffan, Susan B., Compton, David R.

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Alternatives to Monkey Reproductive Toxicology Testing for Biotherapeutics von Hoberman, Alan M., Maki, Kazushige, Mikashima, Fumito, Naota, Misaki, Wange, Ronald L., Lansita, Janice A., Weis, Shawna L.

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Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T Cells von Huang, Yanping, Norton, Darrell D., Precht, Patricia, Martindale, Jennifer L., Burkhardt, Janis K., Wange, Ronald L.

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T cell receptor signaling: beyond complex complexes von Huang, Yanping, Wange, Ronald L

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Complex Complexes: Signaling at the TCR von Wange, Ronald L, Samelson, Lawrence E

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Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation von Shan, Xiaochuan, Czar, Michael J., Bunnell, Stephen C., Liu, Pinghu, Liu, Yusen, Schwartzberg, Pamela L., Wange, Ronald L.

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PTEN permits acute increases in D3‐phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt von Seminario, Maria‐Cristina, Precht, Patricia, Bunnell, Stephen C., Warren, Sarah E., Morris, Christa M., Taub, Dennis, Wange, Ronald L.

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Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton von Dombroski, Derek, Houghtling, Richard A, Labno, Christine M, Precht, Patricia, Takesono, Aya, Caplen, Natasha J, Billadeau, Daniel D, Wange, Ronald L, Burkhardt, Janis K, Schwartzberg, Pamela L

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ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists von Madrenas, Joaquín, Wange, Ronald L., Wang, Jennifer L., Isakov, Noah, Samelson, Lawrence E., Germain, Ronald N.

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Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line von Williams, Brandi L., Schreiber, Kathy L., Zhang, Weiguo, Wange, Ronald L., Samelson, Lawrence E., Leibson, Paul J., Abraham, Robert T.

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TCR Signaling: Another Abl-Bodied Kinase Joins the Cascade von Wange, Ronald L

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Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment von Shan, Xiaochuan, Wange, Ronald L.

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Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN von Gao, Ping, Wange, Ronald L., Zhang, Ning, Oppenheim, Joost J., Howard, O. M. Zack

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Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial von Seminario, Maria-Cristina, Wange, Ronald L.

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