Utilizing Large Functional and Population Genomics Resources for CRISPR/Cas Perturbation Experiment Design von Wang, Qingbo S., Ui-Tei, Kumiko

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Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney Tissue von Noel, Teia, Wang, Qingbo S, Greka, Anna, Marshall, Jamie L

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Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs von Wang, Qingbo S., Kelley, David R., Ulirsch, Jacob, Kanai, Masahiro, Sadhuka, Shuvom, Cui, Ran, Albors, Carlos, Cheng, Nathan, Okada, Yukinori, Aguet, Francois, Ardlie, Kristin G., MacArthur, Daniel G., Finucane, Hilary K.

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SNPD-CRISPR: Single Nucleotide Polymorphism-Distinguishable Repression or Enhancement of a Target Gene Expression by CRISPR System von Maruyama, Shohei, Kusakabe, Takashi, Zou, Xinyi, Kobayashi, Yoshiaki, Asano, Yoshimasa, Wang, Qingbo S., Ui-Tei, Kumiko

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Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis von Sekita, Aiko, Kawasaki, Hiroshi, Fukushima-Nomura, Ayano, Yashiro, Kiyoshi, Tanese, Keiji, Toshima, Susumu, Ashizaki, Koichi, Miyai, Tomohiro, Yazaki, Junshi, Kobayashi, Atsuo, Namba, Shinichi, Naito, Tatsuhiko, Wang, Qingbo S., Kawakami, Eiryo, Seita, Jun, Ohara, Osamu, Sakurada, Kazuhiro, Okada, Yukinori, Amagai, Masayuki, Koseki, Haruhiko

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High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways von Marshall, Jamie L., Noel, Teia, Wang, Qingbo S., Chen, Haiqi, Murray, Evan, Subramanian, Ayshwarya, Vernon, Katherine A., Bazua-Valenti, Silvana, Liguori, Katie, Keller, Keith, Stickels, Robert R., McBean, Breanna, Heneghan, Rowan M., Weins, Astrid, Macosko, Evan Z., Chen, Fei, Greka, Anna

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From genes to health von Okada, Yukinori, Wang, Qingbo S.

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A massive effort links protein-coding gene variants to health von Okada, Yukinori, Wang, Qingbo S.

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Methods for statistical fine-mapping and their applications to auto-immune diseases von Wang, Qingbo S., Huang, Hailiang

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Publisher Correction: Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance von Wang, Qingbo S., Hasegawa, Takanori, Namkoong, Ho, Saiki, Ryunosuke, Edahiro, Ryuya, Sonehara, Kyuto, Tanaka, Hiromu, Azekawa, Shuhei, Chubachi, Shotaro, Takahashi, Yugo, Sakaue, Saori, Namba, Shinichi, Yamamoto, Kenichi, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Makishima, Hideki, Nannya, Yasuhito, Zhang, Zicong, Tsujikawa, Rika, Koike, Ryuji, Takano, Tomomi, Ishii, Makoto, Kimura, Akinori, Inoue, Fumitaka, Kanai, Takanori, Fukunaga, Koichi, Ogawa, Seishi, Imoto, Seiya, Miyano, Satoru, Okada, Yukinori

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Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance von Wang, Qingbo S., Hasegawa, Takanori, Namkoong, Ho, Saiki, Ryunosuke, Edahiro, Ryuya, Sonehara, Kyuto, Tanaka, Hiromu, Azekawa, Shuhei, Chubachi, Shotaro, Takahashi, Yugo, Sakaue, Saori, Namba, Shinichi, Yamamoto, Kenichi, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Makishima, Hideki, Nannya, Yasuhito, Zhang, Zicong, Tsujikawa, Rika, Koike, Ryuji, Takano, Tomomi, Ishii, Makoto, Kimura, Akinori, Inoue, Fumitaka, Kanai, Takanori, Fukunaga, Koichi, Ogawa, Seishi, Imoto, Seiya, Miyano, Satoru, Okada, Yukinori

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Estimating gene-level false discovery probability improves eQTL statistical fine-mapping precision von Wang, Qingbo S, Edahiro, Ryuya, Namkoong, Ho, Hasegawa, Takanori, Shirai, Yuya, Sonehara, Kyuto, Kumanogoh, Atsushi, Ishii, Makoto, Koike, Ryuji, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, Fukunaga, Koichi, Okada, Yukinori

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A structural variation reference for medical and population genetics von Collins, Ryan L., Brand, Harrison, Karczewski, Konrad J., Zhao, Xuefang, Alföldi, Jessica, Francioli, Laurent C., Khera, Amit V., Lowther, Chelsea, Gauthier, Laura D., Wang, Harold, Watts, Nicholas A., Solomonson, Matthew, O’Donnell-Luria, Anne, Baumann, Alexander, Munshi, Ruchi, Walker, Mark, Whelan, Christopher W., Huang, Yongqing, Brookings, Ted, Sharpe, Ted, Stone, Matthew R., Valkanas, Elise, Fu, Jack, Tiao, Grace, Laricchia, Kristen M., Ruano-Rubio, Valentin, Stevens, Christine, Gupta, Namrata, Cusick, Caroline, Margolin, Lauren, Taylor, Kent D., Lin, Henry J., Rich, Stephen S., Post, Wendy S., Chen, Yii-Der Ida, Rotter, Jerome I., Nusbaum, Chad, Philippakis, Anthony, Lander, Eric, Gabriel, Stacey, Neale, Benjamin M., Kathiresan, Sekar, Daly, Mark J., Banks, Eric, MacArthur, Daniel G., Talkowski, Michael E.

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Transcript expression-aware annotation improves rare variant interpretation von Cummings, Beryl B., Karczewski, Konrad J., Kosmicki, Jack A., Seaby, Eleanor G., Watts, Nicholas A., Singer-Berk, Moriel, Mudge, Jonathan M., Karjalainen, Juha, Satterstrom, F. Kyle, O’Donnell-Luria, Anne H., Poterba, Timothy, Seed, Cotton, Solomonson, Matthew, Alföldi, Jessica, Daly, Mark J., MacArthur, Daniel G.

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Evaluating drug targets through human loss-of-function genetic variation von Minikel, Eric Vallabh, Karczewski, Konrad J., Martin, Hilary C., Cummings, Beryl B., Whiffin, Nicola, Rhodes, Daniel, Alföldi, Jessica, Trembath, Richard C., van Heel, David A., Daly, Mark J., Schreiber, Stuart L., MacArthur, Daniel G.

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Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals von Whiffin, Nicola, Karczewski, Konrad J., Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J., Evans, D. Gareth, Roberts, Angharad M., Quaife, Nicholas M., Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O’Donnell-Luria, Anne H., Francioli, Laurent C., Cook, Stuart A., Barton, Paul J. R., MacArthur, Daniel G., Ware, James S.

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A second update on mapping the human genetic architecture of COVID-19 von Jansen, Philip, Nakanishi, Tomoko, Priest, James, Turebayeva, Gulsimzhan, Bouab, Meriem, Bourque, Guillaume, Tse, Sze Man, Faucon, Annika B, Jensen, Björn-Erik Ole, Bals, Robert, Noor, Abdul, Liontos, Angelos, Azuure, Clinton, Blanco-Grau, Albert, Casalone, Elisabetta, Bellelli, Giuseppe, Kurihara, Hayato, Farré, Xavier, Hunkapiller, Julie, Kim, Jin Yong, Lee, Ji Yeon, Jung, Keum Ji, Bretherick, Andrew D, Ostermann, Marlies, Ryan, Lucy, Briton, Kate, Cutler, Sean, Springle, Philippa, Goodwin, Emma, Tibke, Clare, Farley, Sean, Bradley-Potts, Joanne, Whileman, Amanda, Kaye, Callum, Preston, Stephen, Cupitt, Jason, Jakkula, Srinivas, Lamb, Thomas, Hudson, Anne, Clark, Richard, Hudig, Lisa, Roberts, Abigail, Slevin, Kathryn, Thomas, Vicky, Chisholm, Catherine, Scanlon, Jeremy, Jones, Helen, Riches, Joanne, Anderson, Susan, Davies, Rhys, Tebbutt, Julie, Conyngham, Jo-Anna, Hobden, Gillian, Collier, Dawn, Durga, Latha, Wilson, Alison, Finnell, Jez, Serrano-Ruiz, Alfredo, Turner, Patricia, Turney, Sharon, Tutt, Gabriella, Varghese, Mathew, Stuart, Carmel, Wood, Stephen, Cother, Naiara, Brady, Ailbhe, Arden, Tracie, Capps, Nigel, Lennon, Liz, Joseph, Sibet, Jennings, Claire, Revill, Adam, Fletcher, Jo, Sutherland, Isobel, Kaye, Duncan, Whitbread, Jennifer, Hector, Gemma, Goddard, Peter, Lauder, Christen, Oosthuyzen, Wilna, Szoor-Mcelhinney, Helen, Upadhyay, Kamlesh J, Joshi, Chaitanya G, Kabata, Hiroki, Mikami, Yohei, Sonobe, Kazunari, Tateno, Hiroki, Yoshihara, Tomoyuki, Kuwahara, Naota, Sugiura, Hisatoshi, Ishihara, Sayoko, Ismail, Said I, Feng, Yen-Chen Anne, Castano, Luis, Ceballos, Francisco C, Aguado, Jose María, Carbonell, Cristina, Werge, Thomas, Wilson, Daniel J, Serra-Llovich, Alex

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Clonal Hematopoiesis Is Associated with Severe COVID-19 Enhancing Inflammatory Responses in Myeloid Cells von Saiki, Ryunosuke, Edahiro, Ryuya, Sonehara, Kyuto, Wang, Qingbo S, Namkoong, Ho, Hasegawa, Takanori, Tanaka, Hiromu, Azekawa, Shuhei, Chubachi, Shotaro, Namba, Shinichi, Yamamoto, Kenichi, Kakiuchi, Nobuyuki, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Makishima, Hideki, Nannya, Yasuhito, Koike, Ryuji, Takano, Tomomi, Ishii, Makoto, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Kanai, Takanori, Fukunaga, Koichi, Okada, Yukinori, Ogawa, Seishi

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Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity von Edahiro, Ryuya, Shirai, Yuya, Takeshima, Yusuke, Sakakibara, Shuhei, Yamaguchi, Yuta, Murakami, Teruaki, Morita, Takayoshi, Kato, Yasuhiro, Liu, Yu-Chen, Motooka, Daisuke, Naito, Yoko, Takuwa, Ayako, Sugihara, Fuminori, Tanaka, Kentaro, Wing, James B., Sonehara, Kyuto, Tomofuji, Yoshihiko, Namkoong, Ho, Tanaka, Hiromu, Lee, Ho, Fukunaga, Koichi, Hirata, Haruhiko, Takeda, Yoshito, Okuzaki, Daisuke, Kumanogoh, Atsushi, Okada, Yukinori

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Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death von Byrne, Alicia B., Arts, Peer, Ha, Thuong T., Kassahn, Karin S., Pais, Lynn S., O’Donnell-Luria, Anne, Babic, Milena, Frank, Mahalia S. B., Feng, Jinghua, Wang, Paul, Lawrence, David M., Eshraghi, Leila, Arriola, Luis, Toubia, John, Nguyen, Hung, McGillivray, George, Pinner, Jason, McKenzie, Fiona, Morrow, Rebecca, Lipsett, Jill, Manton, Nick, Khong, T. Yee, Moore, Lynette, Liebelt, Jan E., Schreiber, Andreas W., King-Smith, Sarah L., Hardy, Tristan S. E., Jackson, Matilda R., Barnett, Christopher P., Scott, Hamish S.

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