Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors von Nollmann, Friederike I., Galan, Patricia Perez, Fernandez, Javier Garcia, Walter, Heidi K., Magnusson, Johannes P., Medda, Federico, Kratz, Felix, Koester, Stephan D., Ajaj, Khalid Abu, Pes, Lara, Chercheja, Serghei, Warnecke, Anna

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Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice von Nollmann, Friederike I., Galan, Patricia Perez, Fernandez, Javier Garcia, Walter, Heidi K., Magnusson, Johannes P., Medda, Federico, Kratz, Felix, Koester, Stephan D., Ajaj, Khalid Abu, Pes, Lara, Chercheja, Serghei, Warnecke, Anna

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The public’s role in COVID-19 vaccination: Human-centered recommendations to enhance pandemic vaccine awareness, access, and acceptance in the United States von Schoch-Spana, Monica, Brunson, Emily K., Long, Rex, Ruth, Alexandra, Ravi, Sanjana J., Trotochaud, Marc, Borio, Luciana, Brewer, Janesse, Buccina, Joseph, Connell, Nancy, Hall, Laura Lee, Kass, Nancy, Kirkland, Anna, Koonin, Lisa, Larson, Heidi, Lu, Brooke Fisher, Omer, Saad B., Orenstein, Walter A., Poland, Gregory A., Privor-Dumm, Lois, Quinn, Sandra Crouse, Salmon, Daniel, White, Alexandre

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Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant von Spoerke, Jill M., Gendreau, Steven, Walter, Kimberly, Qiu, Jiaheng, Wilson, Timothy R., Savage, Heidi, Aimi, Junko, Derynck, Mika K., Chen, Meng, Chan, Iris T., Amler, Lukas C., Hampton, Garret M., Johnston, Stephen, Krop, Ian, Schmid, Peter, Lackner, Mark R.

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Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise von Adkins, Joshua N., Dasari, Surendra, Drugan, Jonelle K., Radom-Aizik, Shlomit, Snyder, Michael P., Walsh, Martin J., Adkins, Joshua N., Amar, David, Evans, Charles R., Li, Yafeng, Radom-Aizik, Shlomit, Sanford, James A., Schenk, Simon, Lee Alekel, D., Boyce, Amanda T., Fleg, Jerome L., McGowan, Joan A., Nierras, Concepcion, Pai, Vinay, Peterson, Charlotte, Ramos, Ed, Roary, Mary C., Xia, Ashley, Rooney, Jessica, Miller, Michael E., Ambrosius, Walter T., Jack Rejeski, W., Lu, Ching-ju, Raue, Ulrika, Lester, Bridget, Bergman, Bryan C., Bessesen, David H., Jankowski, Catherine M., Moreau, Kerrie L., Schauer, Irene E., Huffman, Kim M., Johnson, Johanna L., Kelly, Leslie, Broskey, Nick, Goodpaster, Bret H., Sparks, Lauren M., Cooper, Dan M., Haddad, Fadia, Rankinen, Tuomo, Ravussin, Eric, Johannsen, Neil, Harris, Melissa, Jakicic, John M., Newman, Anne B., Forman, Daniel D., Rogers, Renee J., Page, Lindsay C., Rasmussen, Blake B., Musi, Nicolas, Patel, Darpan, Gelfond, Jonathan, Burns, Aisling, Bamman, Marcas M., Buford, Thomas W., Bodine, Sue C., Hirshman, Michael F., Albertson, Brent G., Qian, Wei-Jun, Piehowski, Paul, Gritsenko, Marina A., Hansen, Joshua N., Carr, Steve, Jean-Beltran, Pierre M., Keshishian, Hasmik, Krug, Karsten, Pearce, Cadence, Ivanova, Anna A., Ortlund, Eric A., Sealfon, Stuart C., Zaslavsky, Elena, Nair, Venugopalan, Li, SiDe, Sun, Yifei, Pincas, Nhanna, Seenarine, Nitish, Lappalainen, Tuuli, Sreekumaran Nair, K., Gay, Nicole R., Zebarjadi, Navid, Burant, Charles F., Li, Jun Z., Kachman, Maureen, Raskind, Alexander B., Gerszten, Robert, Robbins, Jeremy, Newgard, Christopher B., Jimenez-Morales, David, Raja, Archana, Zhen, Jimmy, Suk Kim, Young, Christle, Jeffrey W., Marwaha, Shruti, Hershman, Steven G., Hastie, Trevor, Tibshirani, Robert

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Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, rando... von Bachert, Claus, Han, Joseph K, Desrosiers, Martin, Hellings, Peter W, Amin, Nikhil, Lee, Stella E, Mullol, Joaquim, Greos, Leon S, Bosso, John V, Laidlaw, Tanya M, Cervin, Anders U, Maspero, Jorge F, Hopkins, Claire, Olze, Heidi, Canonica, G Walter, Paggiaro, Pierluigi, Cho, Seong H, Fokkens, Wytske J, Fujieda, Shigeharu, Zhang, Mei, Lu, Xin, Fan, Chunpeng, Draikiwicz, Steven, Kamat, Siddhesh A, Khan, Asif, Pirozzi, Gianluca, Patel, Naimish, Graham, Neil M H, Ruddy, Marcella, Staudinger, Heribert, Weinreich, David, Stahl, Neil, Yancopoulos, George D, Mannent, Leda P

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Upadacitinib monotherapy versus methotrexate monotherapy in patients with rheumatoid arthritis: efficacy and safety through 5 years in the SELECT-EARLY randomized controlled trial von van Vollenhoven, Ronald, Strand, Vibeke, Takeuchi, Tsutomu, Chávez, Nilmo, Walter, Pablo Mannucci, Singhal, Atul, Swierkot, Jerzy, Khan, Nasser, Bu, Xianwei, Li, Yihan, Penn, Sara K, Camp, Heidi S, Aelion, Jacob

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Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders von Eijsbouts, Chris, Zheng, Tenghao, Kennedy, Nicholas A., Bonfiglio, Ferdinando, Anderson, Carl A., Moutsianas, Loukas, Holliday, Joanne, Shi, Jingchunzi, Shringarpure, Suyash, Voda, Alexandru-Ioan, Farrugia, Gianrico, Franke, Andre, Hübenthal, Matthias, Abecasis, Gonçalo, Zawistowski, Matthew, Skogholt, Anne Heidi, Ness-Jensen, Eivind, Hveem, Kristian, Esko, Tõnu, Teder-Laving, Maris, Zhernakova, Alexandra, Camilleri, Michael, Boeckxstaens, Guy, Whorwell, Peter J., Spiller, Robin, McVean, Gil, D’Amato, Mauro, Jostins, Luke, Parkes, Miles

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The Extended Tails of Palomar 5: A 10° Arc of Globular Cluster Tidal Debris von Odenkirchen, Michael, Grebel, Eva K, Dehnen, Walter, Rix, Hans-Walter, Yanny, Brian, Newberg, Heidi Jo, Rockosi, Constance M, Martínez-Delgado, David, Brinkmann, Jon, Pier, Jeffrey R

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Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial von Pahor, Marco, Guralnik, Jack M, Ambrosius, Walter T, Blair, Steven, Bonds, Denise E, Church, Timothy S, Espeland, Mark A, Fielding, Roger A, Gill, Thomas M, Groessl, Erik J, King, Abby C, Kritchevsky, Stephen B, Manini, Todd M, McDermott, Mary M, Miller, Michael E, Newman, Anne B, Rejeski, W. Jack, Sink, Kaycee M, Williamson, Jeff D

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Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas von Fischer, Anja, Albert, Thomas K., Moreno, Natalia, Interlandi, Marta, Mormann, Jana, Glaser, Selina, Patil, Paurnima, de Faria, Flavia W., Richter, Mathis, Verma, Archana, Balbach, Sebastian T., Wagener, Rabea, Bens, Susanne, Dahlum, Sonja, Göbel, Carolin, Münter, Daniel, Inserte, Clara, Graf, Monika, Kremer, Eva, Melcher, Viktoria, Di Stefano, Gioia, Santi, Raffaella, Chan, Alexander, Dogan, Ahmet, Bush, Jonathan, Hasselblatt, Martin, Cheng, Sylvia, Spetalen, Signe, Fosså, Alexander, Hartmann, Wolfgang, Herbrüggen, Heidi, Robert, Stella, Oyen, Florian, Dugas, Martin, Walter, Carolin, Sandmann, Sarah, Varghese, Julian, Rossig, Claudia, Schüller, Ulrich, Tzankov, Alexandar, Pedersen, Martin B., d’Amore, Francesco A., Mellgren, Karin, Kontny, Udo, Kancherla, Venkatesh, Veloza, Luis, Missiaglia, Edoardo, Fataccioli, Virginie, Gaulard, Philippe, Burkhardt, Birgit, Soehnlein, Oliver, Klapper, Wolfram, de Leval, Laurence, Siebert, Reiner, Kerl, Kornelius

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Light Intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions... von Bann, David, Hire, Don, Manini, Todd, Cooper, Rachel, Botoseneanu, Anda, McDermott, Mary M, Pahor, Marco, Glynn, Nancy W, Fielding, Roger, King, Abby C, Church, Timothy, Ambrosius, Walter T, Gill, Thomas M, Gill, Thomas

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The insect pathogenic bacterium Xenorhabdus innexi has attenuated virulence in multiple insect model hosts yet encodes a potent mosquitocidal toxin von Kim, Il-Hwan, Aryal, Sudarshan K, Aghai, Dariush T, Casanova-Torres, Ángel M, Hillman, Kai, Kozuch, Michael P, Mans, Erin J, Mauer, Terra J, Ogier, Jean-Claude, Ensign, Jerald C, Gaudriault, Sophie, Goodman, Walter G, Goodrich-Blair, Heidi, Dillman, Adler R

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The Minnesota Critical Care Working Group 1: Monitoring and coordinating statewide critical care surge response in the COVID-19 pandemic, March 2020 through July 1, 2021 von Dichter, Jeffrey R, Brown, Daniel, Zamorano, Clara, Cohen, Joshua, Miller, Elizabeth A, Niccum, David E, LeClaire, Michele, De Jong, Christina Bastin, Diebold, Deanna, Lyons, Jacob, Reilkoff, Ronald, Erickson, Heidi L, Martinelli, Joseph, Fischer, Jennifer A, Mairose, Kyle, Kallestad, Jason, Chell, Christine, Shadiow, Adam, Stoen, Shawn, Hick, John L, Petersen-Kroeber, Cheryl, Seaberg, Judy, McLachlan, Erin, Waterman, Alexandra T, James, Walter Y, MacDonell, Sean, Risser, James, Klemond, Tom, DeMartino, Erin S, Wu, Joel, DeBruin, Debra, Wolf, Susan M, Sederstrom, Nneka O, Baum, Karyn D, Greenlee, Kay, Strike, Helen, Kettler, Paul A, Boehland, Andrea, Goodman, Kimberly A, Maslonka, Ken K, Wolf, Jack M, Schoenecker, Jennifer, Kesler, Sarah

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Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia von Ley, Timothy J, Miller, Christopher, Ding, Li, Raphael, Benjamin J, Mungall, Andrew J, Robertson, A Gordon, Hoadley, Katherine, Triche, Jr, Timothy J, Laird, Peter W, Baty, Jack D, Fulton, Lucinda L, Fulton, Robert, Heath, Sharon E, Kalicki-Veizer, Joelle, Kandoth, Cyriac, Klco, Jeffery M, Koboldt, Daniel C, Kanchi, Krishna-Latha, Kulkarni, Shashikant, Lamprecht, Tamara L, Larson, David E, Lin, Ling, Lu, Charles, McLellan, Michael D, McMichael, Joshua F, Payton, Jacqueline, Schmidt, Heather, Spencer, David H, Tomasson, Michael H, Wallis, John W, Wartman, Lukas D, Watson, Mark A, Welch, John, Wendl, Michael C, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Butterfield, Yaron, Chiu, Readman, Chu, Andy, Chuah, Eric, Chun, Hye-Jung, Corbett, Richard, Dhalla, Noreen, Guin, Ranabir, He, An, Hirst, Carrie, Hirst, Martin, Holt, Robert A, Jones, Steven, Karsan, Aly, Lee, Darlene, Li, Haiyan I, Marra, Marco A, Mayo, Michael, Moore, Richard A, Mungall, Karen, Parker, Jeremy, Pleasance, Erin, Plettner, Patrick, Schein, Jacquie, Stoll, Dominik, Swanson, Lucas, Tam, Angela, Thiessen, Nina, Varhol, Richard, Wye, Natasja, Zhao, Yongjun, Gabriel, Stacey, Getz, Gad, Sougnez, Carrie, Zou, Lihua, Leiserson, Mark D M, Vandin, Fabio, Wu, Hsin-Ta, Applebaum, Frederick, Baylin, Stephen B, Akbani, Rehan, Broom, Bradley M, Chen, Ken, Motter, Thomas C, Nguyen, Khanh, Weinstein, John N, Zhang, Nianziang, Ferguson, Martin L, Adams, Christopher, Black, Aaron, Bowen, Jay, Gastier-Foster, Julie, Grossman, Thomas, Lichtenberg, Tara, Wise, Lisa, Davidsen, Tanja, Demchok, John A, Shaw, Kenna R Mills, Sheth, Margi, Sofia, Heidi J, Yang, Liming, Downing, James R, Eley, Greg

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Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial von Levin, Johannes, Maaß, Sylvia, Schuberth, Madeleine, Giese, Armin, Oertel, Wolfgang H, Poewe, Werner, Trenkwalder, Claudia, Wenning, Gregor K, Mansmann, Ulrich, Südmeyer, Martin, Eggert, Karla, Mollenhauer, Brit, Lipp, Axel, Löhle, Matthias, Classen, Joseph, Münchau, Alexander, Kassubek, Jan, Gandor, Florin, Berg, Daniela, Egert-Schwender, Silvia, Eberhardt, Cornelia, Paul, Friedemann, Bötzel, Kai, Ertl-Wagner, Birgit, Huppertz, Hans-Jürgen, Ricard, Ingrid, Höglinger, Günter U, André, Elisabeth, Blankenstein, Christiane, Canelo, Monica, Düring, Marco, Ebentheuer, Jens, Fricke, Christopher, Gerbes, Alexander, Groiss, Stefan, Gruber, Doreen, Hartmann, Christian, Kirchner, Thomas, Kroneberg, Daniel, Kunz, Martin, Lorenzl, Stefan, Moldovan, Alexia, Noda, Anna, Pape, Heidi, Respondek, Gesine, Schäffer, Eva, Schneider, Martina, Schnitzler, Alfons, Schulz-Schaeffer, Walter, Schwarz, Johannes, Skowronek, Cornelia, Storch, Alexander, Tadic, Vera, Vadász, Dávid, Zimmermann, Benno

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The Ghost of Sagittarius and Lumps in the Halo of the Milky Way von Newberg, Heidi Jo, Yanny, Brian, Rockosi, Connie, Grebel, Eva K, Rix, Hans-Walter, Brinkmann, Jon, Csabai, Istvan, Hennessy, Greg, Hindsley, Robert B, Ibata, Rodrigo, Ivezić, Zeljko, Lamb, Don, Nash, E. Thomas, Odenkirchen, Michael, Rave, Heather A, Schneider, D. P, Smith, J. Allyn, Stolte, Andrea, York, Donald G

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The Minnesota Critical Care Working Group 2: Crisis conditions during the COVID-19 Pandemic, July 2021 through March 2022 von Kesler, Sarah M, De Jong, Christina Bastin, Chell, Christine, DeBruin, Debra, Erickson, Heidi L, Goodman, Kimberly A, James, Walter, Kallestad, Jason, Klemond, Tom, McLachlan, Erin, Petersen-Kroeber, Cheryl, Risser, James, DeMartino, Erin S, Waterman, Alexandra T, Wolf, Susan M, Wu, Joel, Zamorano, Clara, Baum, Karyn, Brown, Daniel, Cohen, Joshua, Diebold, Deanna, Fischer, Jennifer A, Greenlee, Kay, Hick, John, Kettler, Paul, LeClaire, Michele, Lyons, Jacob, MacDonell, Sean, Mairose, Kyle, Boehland, Andrea, Martinelli, Joseph, Miller, Elizabeth A, Niccum, David E, Reilkoff, Ronald, Seaberg, Judy, Sederstrom, Nneka O, Shadiow, Adam, Stoen, Shawn, Strike, Helen, Maslonka, Ken K, Wolf, Jack M, Schoenecker, Jennifer, Dichter, Jeffrey R

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Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial von Schmader, Kenneth E, Liu, Christine K, Flannery, Brendan, Rountree, Wes, Auerbach, Heidi, Barnett, Elizabeth D, Schlaudecker, Elizabeth P, Todd, Christopher A, Poniewierski, Marek, Staat, Mary A, Harrington, Theresa, Li, Rongxia, Broder, Karen R, Walter, Emmanuel B

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Changing Practices of Tourism Stakeholders in Covid-19 Affected Destinations von Cakmak, Erdinc, Isaac, Rami K, Butler, Richard

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