Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function von Hackos, David H., Lupardus, Patrick J., Grand, Teddy, Chen, Yelin, Wang, Tzu-Ming, Reynen, Paul, Gustafson, Amy, Wallweber, Heidi J.A., Volgraf, Matthew, Sellers, Benjamin D., Schwarz, Jacob B., Paoletti, Pierre, Sheng, Morgan, Zhou, Qiang, Hanson, Jesse E.

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The Structural Basis for Class II Cytokine Receptor Recognition by JAK1 von Ferrao, Ryan, Wallweber, Heidi J.A., Ho, Hoangdung, Tam, Christine, Franke, Yvonne, Quinn, John, Lupardus, Patrick J.

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Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination von Dueber, Erin C., Schoeffler, Allyn J., Lingel, Andreas, Elliott, J. Michael, Fedorova, Anna V., Giannetti, Anthony M., Zobel, Kerry, Maurer, Brigitte, Varfolomeev, Eugene, Wu, Ping, Wallweber, Heidi J. A., Hymowitz, Sarah G., Deshayes, Kurt, Vucic, Domagoj, Fairbrother, Wayne J.

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GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile von Villemure, Elisia, Volgraf, Matthew, Jiang, Yu, Wu, Guosheng, Ly, Cuong Q, Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Lupardus, Patrick J, Wallweber, Heidi J. A, Liederer, Bianca M, Deshmukh, Gauri, Plise, Emile, Tay, Suzanne, Wang, Tzu-Ming, Hanson, Jesse E, Hackos, David H, Scearce-Levie, Kimberly, Schwarz, Jacob B, Sellers, Benjamin D

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Structural basis of recognition of interferon-α receptor by tyrosine kinase 2 von Wallweber, Heidi J A, Tam, Christine, Franke, Yvonne, Starovasnik, Melissa A, Lupardus, Patrick J

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The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable... von Folkes, Adrian J, Ahmadi, Khatereh, Alderton, Wendy K, Alix, Sonia, Baker, Stewart J, Box, Gary, Chuckowree, Irina S, Clarke, Paul A, Depledge, Paul, Eccles, Suzanne A, Friedman, Lori S, Hayes, Angela, Hancox, Timothy C, Kugendradas, Arumugam, Lensun, Letitia, Moore, Pauline, Olivero, Alan G, Pang, Jodie, Patel, Sonal, Pergl-Wilson, Giles H, Raynaud, Florence I, Robson, Anthony, Saghir, Nahid, Salphati, Laurent, Sohal, Sukhjit, Ultsch, Mark H, Valenti, Melanie, Wallweber, Heidi J.A, Wan, Nan Chi, Wiesmann, Christian, Workman, Paul, Zhyvoloup, Alexander, Zvelebil, Marketa J, Shuttleworth, Stephen J

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Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design von Volgraf, Matthew, Sellers, Benjamin D, Jiang, Yu, Wu, Guosheng, Ly, Cuong Q, Villemure, Elisia, Pastor, Richard M, Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Sun, Liang, Fu, Yuhong, Lupardus, Patrick J, Wallweber, Heidi J.A, Liederer, Bianca M, Deshmukh, Gauri, Plise, Emile, Tay, Suzanne, Reynen, Paul, Herrington, James, Gustafson, Amy, Liu, Yichin, Dirksen, Akim, Dietz, Matthias G. A, Liu, Yanzhou, Wang, Tzu-Ming, Hanson, Jesse E, Hackos, David, Scearce-Levie, Kimberly, Schwarz, Jacob B

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) von Flygare, John A, Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T, Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O, Feng, Bainian, Franklin, Matthew C, Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G, La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Young, Shin G, Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J, Wallweber, Heidi J. A, Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M, Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J

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Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation von Ferrao, Ryan D, Wallweber, Heidi Ja, Lupardus, Patrick J

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The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site von de Leon-Boenig, Gladys, Bowman, Krista K., Feng, Jianwen A., Crawford, Terry, Everett, Christine, Franke, Yvonne, Oh, Angela, Stanley, Mark, Staben, Steven T., Starovasnik, Melissa A., Wallweber, Heidi J.A., Wu, Jiansheng, Wu, Lawren C., Johnson, Adam R., Hymowitz, Sarah G.

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Multiple Novel Classes of APRIL-specific Receptor-blocking Peptides Isolated by Phage Display von Gordon, Nathaniel C., Lien, Samantha, Johnson, Jeremy, Wallweber, Heidi J.A., Tran, Thuy, Currell, Bridget, Mathieu, Mary, Quan, Clifford, Starovasnik, Melissa A., Hymowitz, Sarah G., Kelley, Robert F.

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Correction: Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs von Zobel, Kerry, Wang, Lan, Varfolomeev, Eugene, Franklin, Matthew C, Elliott, Linda O, Wallweber, Heidi J. A, Okawa, David C, Flygare, John A, Vucic, Domagoj, Fairbrother, Wayne J, Deshayes, Kurt

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Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding von Hymowitz, Sarah G, Patel, Darshana R, Wallweber, Heidi J A, Runyon, Steven, Yan, Minhong, Yin, Jianping, Shriver, Stephanie K, Gordon, Nathaniel C, Pan, Borlan, Skelton, Nicholas J, Kelley, Robert F, Starovasnik, Melissa A

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Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function von Hackos, David H., Lupardus, Patrick J., Grand, Teddy, Chen, Yelin, Wang, Tzu-Ming, Reynen, Paul, Gustafson, Amy, Wallweber, Heidi J. A., Volgraf, Matthew, Sellers, Benjamin D., Schwarz, Jacob B., Paoletti, Pierre, Sheng, Morgan, Zhou, Qiang, Hanson, Jesse E.

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The Crystal Structures of EDA-A1 and EDA-A2: Splice Variants with Distinct Receptor Specificity von Hymowitz, Sarah G, Compaan, Deanne M, Yan, Minhong, Wallweber, Heidi J.A, Dixit, Vishva M, Starovasnik, Melissa A, de Vos, Abraham M

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Antagonists Induce a Conformational Change in clAP1 That Promotes Autoubiquitination von DUEBER, Erin C, SCHOEFFLER, Allyn J, WALLWEBER, Heidi J. A, HYMOWITZ, Sarah G, DESHAYES, Kurt, VUCIC, Domagoj, FAIRBROTHER, Wayne J, LINGEL, Andreas, ELLIOTT, J. Michael, FEDOROVA, Anna V, GIANNETTI, Anthony M, ZOBEL, Kerry, MAURER, Brigitte, VARFOLOMEEV, Eugene, PING WU

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis von Varfolomeev, Eugene, Blankenship, John W, Wayson, Sarah M, Fedorova, Anna V, Kayagaki, Nobuhiko, Garg, Parie, Zobel, Kerry, Dynek, Jasmin N, Elliott, Linda O, Wallweber, Heidi J A, Flygare, John A, Fairbrother, Wayne J, Deshayes, Kurt, Dixit, Vishva M, Vucic, Domagoj

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Structures of APRIL-Receptor Complexes von Hymowitz, Sarah G., Patel, Darshana R., Wallweber, Heidi J.A., Runyon, Steven, Yan, Minhong, Yin, JianPing, Shriver, Stephanie K., Gordon, Nathaniel C., Pan, Borlan, Skelton, Nicholas J., Kelley, Robert F., Starovasnik, Melissa A.

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Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Commentary von RADER, Christoph, BARBAS, Carlos F, QIAN GONG, KELLEY, Robert F, DEFORGE, Laura E, MARTIN, Flavius, STAROVASNIK, Melissa A, FUH, Germaine, LEE, Chingwei V, HYMOWITZ, Sarah G, WALLWEBER, Heidi J, GORDON, Nathaniel C, BILLECI, Karen L, TSAI, Siao-Ping, COMPAAN, Deanne M, JIANPING YIN

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Compositions and methods for the screening pro-apoptotic compounds von VUCIC DOMAGOJ, ELLIOTT LINDA O, FAIRBROTHER WAYNE J, ACKERLY WALLWEBER HEIDI J, FRANKLIN MATTHEW C, KADKHODAYAN SALOUMEH, SALVESEN GUY

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