An analysis of the attrition of drug candidates from four major pharmaceutical companies von Waring, Michael J., Arrowsmith, John, Leach, Andrew R., Leeson, Paul D., Mandrell, Sam, Owen, Robert M., Pairaudeau, Garry, Pennie, William D., Pickett, Stephen D., Wang, Jibo, Wallace, Owen, Weir, Alex

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A survey of core replacements in indole-based HIV-1 attachment inhibitors von Wang, Tao, Wallace, Owen B., Zhang, Zhongxing, Fang, Haiquan, Yang, Zhong, Robinson, Brett A., Spicer, Timothy P., Gong, Yi-Fei, Blair, Wade S., Shi, Pei-Yong, Lin, Pin-Fang, Deshpande, Milind, Meanwell, Nicholas A., Kadow, John F.

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Discovery of 4-Benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806):  A Novel HIV-1 Attachment Inhibitor That Interferes with CD4-gp... von Wang, Tao, Zhang, Zhongxing, Wallace, Owen B, Deshpande, Milind, Fang, Haiquan, Yang, Zheng, Zadjura, Lisa M, Tweedie, Donald L, Huang, Stella, Zhao, Fang, Ranadive, Sunanda, Robinson, Brett S, Gong, Yi-Fei, Ricarrdi, Keith, Spicer, Timothy P, Deminie, Carol, Rose, Ronald, Wang, Hwei-Gene Heidi, Blair, Wade S, Shi, Pei-Yong, Lin, Pin-fang, Colonno, Richard J, Meanwell, Nicholas A

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Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns von MEANWELL, Nicholas A, WALLACE, Owen B, YEUNG, Kap-Sun, ZHILEI QIU, WRIGHT, J. J. Kim, ZHENG YANG, ZADJURA, Lisa, TWEEDIE, Donald L, YEOLA, Suresh, FANG ZHAO, RANADIVE, Sunanda, ROBINSON, Brett A, HAIQUAN FANG, GONG, Yi-Fei, WANG, Hwei-Gene Heidi, BLAIR, Wade S, SHI, Pei-Yong, COLONNO, Richard J, LIN, Pin-Fang, WANG, Henry, DESHPANDE, Milind, TAO WANG, ZHIWEI YIN, ZHONGXING ZHANG, PEARCE, Bradley C, JAMES, Jennifer

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Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity von Meanwell, Nicholas A., Wallace, Owen B., Wang, Henry, Deshpande, Milind, Pearce, Bradley C., Trehan, Ashok, Yeung, Kap-Sun, Qiu, Zhilei, Wright, J.J. Kim, Robinson, Brett A., Gong, Yi-Fei, Wang, Hwei-Gene Heidi, Blair, Wade S., Shi, Pei-Yong, Lin, Pin-fang

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Tetrahydroquinoline-Based selective estrogen receptor modulators (SERMs) von Wallace, Owen B, Lauwers, Kenneth S, Jones, Scott A, Dodge, Jeffrey A

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Inhibitors of Aβ production: solid-phase synthesis and SAR of α-hydroxycarbonyl derivatives von Wallace, Owen B., Smith, David W., Deshpande, Milind S., Polson, Craig, Felsenstein, Kevin M.

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HIV-1 entry – an expanding portal for drug discovery von Blair, Wade S, Lin, Pin-Fang, Meanwell, Nicholas A, Wallace, Owen B

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A Selective Estrogen Receptor Modulator Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats von Hummel, Conrad W, Geiser, Andrew G, Bryant, Henry U, Cohen, Ilene R, Dally, Robert D, Fong, Kin Chiu, Frank, Scott A, Hinklin, Ronald, Jones, Scott A, Lewis, George, McCann, Denis J, Rudmann, Daniel G, Shepherd, Timothy A, Tian, Hongqi, Wallace, Owen B, Wang, Minmin, Wang, Yong, Dodge, Jeffrey A

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A New Selective Estrogen Receptor Modulator with Potent Uterine Antagonist Activity, Agonist Activity in Bone, and Minimal Ovarian Stimulation von Geiser, Andrew G, Hummel, Conrad W, Draper, Michael W, Henck, Judith W, Cohen, Ilene R, Rudmann, Daniel G, Donnelly, Kevin B, Adrian, Mary D, Shepherd, Timothy A, Wallace, Owen B, McCann, Denis J, Oldham, Samuel W, Bryant, Henry U, Sato, Masahiko, Dodge, Jeffrey A

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A Selective Estrogen Receptor Modulator for the Treatment of Hot Flushes von Wallace, Owen B, Lauwers, Kenneth S, Dodge, Jeffrey A, May, Scott A, Calvin, Joel R, Hinklin, Ronald, Bryant, Henry U, Shetler, Pamela K, Adrian, Mary D, Geiser, Andrew G, Sato, Masahiko, Burris, Thomas P

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In Vitro Characterization of FTX6058, a Novel Small Molecule Fetal Hemoglobin Inducer for Sickle Cell Disease von Stuart, Billy, Rahl, Peter, Appiah, Kingsley, Efremov, Ivan, Thompson, Lorin, Wallace, Owen, Moxham, Christopher

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Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons von Graef, John D., Wu, Hao, Ng, Carrie, Sun, Chicheng, Villegas, Vivian, Qadir, Deena, Jesseman, Kimberly, Warren, Stephen T., Jaenisch, Rudolf, Cacace, Angela, Wallace, Owen

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In Vivo Characterization of Ftx-6058, a Novel Small Molecular Fetal Hemoglobin Inducer for Sickle Cell Disease von Xie, Keqiang, Roth, Mark, Efremov, Ivan, Silver, Serena, Ronco, Lucienne, Thompson, Lorin, Stickland, Kim, Moxham, Christopher, Wallace, Owen

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N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors von Parker, Michael F., Barten, Donna M., Bergstrom, Carl P., Bronson, Joanne J., Corsa, Jason A., Deshpande, Milind S., Felsenstein, Kevin M., Guss, Valerie L., Hansel, Steven B., Johnson, Graham, Keavy, Daniel J., Lau, Wai Y., Mock, Jeremy, Prasad, C.V.C., Polson, Craig T., Sloan, Charles P., Smith, David W., Wallace, Owen B., Wang, Henry H., Williams, Andrew, Zheng, Ming

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p38 alpha Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy von Rojas, L. Alejandro, Valentine, Erin, Accorsi, Anthony, Maglio, Joseph, Shen, Ning, Robertson, Alan, Kazmirski, Steven, Rahl, Peter, Tawil, Rabi, Cadavid, Diego, Thompson, Lorin A., Ronco, Lucienne, Chang, Aaron N., Cacace, Angela M., Wallace, Owen

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Tu1727 MRT-6160, A VAV1-DIRECTED MOLECULAR GLUE DEGRADER, INHIBITS DISEASE PROGRESSION IN A T-CELL TRANSFER MEDIATED MURINE COLITIS MODEL CONCOMITANT WITH REDUCED CALPROTECTIN EXPR... von Cartwright, Adam N., Desai, Foram, Roditi, Laura, Vora, Shailee, Gyger, Lucas, Nguyen, Sophia, Trouilloud, Alexandra, Lam, Daniel, Trenh, Peter, Lucas, Xavi, Zlotosch, Mary, Liardo, Elisa, Wible, Daric, Oleinikovas, Vladas, Lamberto, Ilaria, Demarco, Bradley, King, Chris, Bonenfant, Debora, Krishnan, Eswar, De Beukelaer, Steven, Townson, Sharon, Wallace, Owen B., Janku, Filip, McAllister, Laura, Paterson, Alison, Peluso, Marisa

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Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome von Malachowski, Thomas, Chandradoss, Keerthivasan Raanin, Boya, Ravi, Zhou, Linda, Cook, Ashley L, Su, Chuanbin, Pham, Kenneth, Haws, Spencer A, Kim, Ji Hun, Ryu, Han-Seul, Ge, Chunmin, Luppino, Jennifer M, Nguyen, Son C, Titus, Katelyn R, Gong, Wanfeng, Wallace, Owen, Joyce, Eric F, Wu, Hao, Rojas, Luis Alejandro, Phillips-Cremins, Jennifer E

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Discovery of a ZIP7 inhibitor from a Notch pathway screen von Nolin, Erin, Gans, Sara, Llamas, Luis, Bandyopadhyay, Somnath, Brittain, Scott M., Bernasconi-Elias, Paula, Carter, Kyle P., Loureiro, Joseph J., Thomas, Jason R., Schirle, Markus, Yang, Yi, Guo, Ning, Roma, Guglielmo, Schuierer, Sven, Beibel, Martin, Lindeman, Alicia, Sigoillot, Frederic, Chen, Amy, Xie, Kevin X., Ho, Samuel, Reece-Hoyes, John, Weihofen, Wilhelm A., Tyskiewicz, Kayla, Hoepfner, Dominic, McDonald, Richard I., Guthrie, Nicolette, Dogra, Abhishek, Guo, Haibing, Shao, Jian, Ding, Jian, Canham, Stephen M., Boynton, Geoff, George, Elizabeth L., Kang, Zhao B., Antczak, Christophe, Porter, Jeffery A., Wallace, Owen, Tallarico, John A., Palmer, Amy E., Jenkins, Jeremy L., Jain, Rishi K., Bushell, Simon M., Fryer, Christy J.

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Induction of Fetal Hemoglobin By FTX6058, a Novel Small Molecule Development Candidate von Rahl, Peter, Efremov, Ivan, Stuart, Billy, Xie, Keqiang, Roth, Mark, Barnes, Richard, Appiah, Kingsley, Peters, David, Li, Qingyi, Kazmirski, Steven, Bruno, Paul, Stickland, Kim, Ronco, Lucienne, Cadavid, Diego, Thompson, Lorin, Wallace, Owen, Moxham, Christopher

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