Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis von Wallace, LaShanale, Obeng, Esther A

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Diversity Is a Strength of Cancer Research in the U.S von Merad, Miriam, Posey, Avery D., Olivero, Ofelia, Singh, Pankaj K., Mouneimne, Ghassan, Li, Lingyin, Wallace, LaShanale M., Hayes, Tikvah K.

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Abstract 5163: Mitochondrial mutations and gene expression analysis in colorectal adenopolyps von Wallace, LaShanale M., Mehrabi, Sharifeh, Yao, Xuebiao, Aikhionbare, Felix

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SF3B1 K700E Alters the Splicing of Metabolism and Stress Response Genes, Attenuating the Effect of DNMT3A Mutations in MDS von Wallace, Lashanale, Myers, Jacquelyn A., Engelken, Mark, Cullins, David, Sheppard, Heather, Obeng, Esther A.

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Abstract 2228: Differential expression of MT-ATPase and COXIV genes in colorectal adenopolyps von Wallace, Lashanale, Cherian, Anju, Aikhionbare, Felix

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A Murine Model Harboring Cooperating DNMT3A and SF3B1 Mutations Phenocopies SF3B1 Driven Myelodysplastic Syndrome von Wallace, Lashanale, Leal-Cervantes, Ana, Metidji, Amina, Myers, Jacquelyn, Rolle, Chandra, Tillman, Heather, Obeng, Esther A.

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PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo von Rahmani, Mohamed, Aust, Mandy Mayo, Benson, Elisa C, Wallace, LaShanale, Friedberg, Jonathan, Grant, Steven

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3194 – CLONAL HEMATOPOIESIS-ASSOCIATED DNMT3A MUTATIONS CAUSE INCREASED T CELL ACTIVATION AND DECREASED LEUKEMIC TUMOR BURDEN von Wallace, LaShanale, Engelken, Mark, Metidji, Amina, Myers, Jacquelyn, Sheppard, Heather, Crawford, Jeremy, Harper, John, Cullins, David, Thomas, Paul, Obeng, Esther

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3211 – SF3B1/DNMT3A CO-MUTATIONS MITIGATES DNMT3A PHENOTYPE IN HEMATOPOIETIC STEM AND PROGENITOR CELLS von Wallace, LaShanale, Engelken, Mark, Metidji, Amina, Myers, Jacquelyn, Leal-Cervantes, Ana, Tillman, Heather, Obeng, Esther

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3137 – A MODIFIED ACTIVIN RECEPTOR TYPE IIB LIGAND TRAP (RAP-536) IMPROVES ANEMIA IN SF3B1K700E MICE BY PROMOTING EARLY-STAGE ERYTHROPOIESIS AND IMPROVING ALTERNATIVE SPLICING von Metidji, Amina, Campbell, Koral, Myers, Jacquelyn, Wallace, LaShanale, Leal-Cervantes, Ana, Obeng, Esther

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3185 – PROTEOMIC ANALYSIS OF TERMINAL ERYTHROPOIESIS IN THE SF3B1 MUTATION MOUSE MODEL von Tseng, Chun-Chih, Metidji, Amina, Wallace, LaShanale, Yu, Kaiwen, Wu, Long, Engelken, Mark, Cullins, David, Myers, Jacquelyn, Leal-Cervantes, Ana, Wang, Xusheng, High, Anthony, Obeng, Esther

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Abstract 1804: Role of microRNAs in colorectal adenoma progression von Wallace, LaShanale M., Chaudhry, Aneese F., Aikhionbare, Karen I., Yao, Xuebiao, Aikhionbare, Felix O.

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3138 – EPIGENETIC REGULATORS TET2 AND POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) COORDINATE GENE EXPRESSION IN MYELODYSPLASTIC SYNDROME (MDS) von Myers, Jacquelyn, Henriet, Elodie, Wallace, LaShanale, Metidji, Amina, Skorupa, Jordan, Leal-Cervantes, Ana, Pruett-Miller, Shondra, Fan, Yiping, Iacobucci, Ilaria, Haferlach, Torsten, Mullighan, Charles, Obeng, Esther

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Abstract 2093: Alternative splicing in hematopoietic stem cells is affected by the loss of DNMT3A von Wallace, LaShanale, Leal-Cervantes, Ana, Myers, Jacquelyn, Fan, Yiping, Campbell, Koral, Barajas, Juan Martin, Calindi, Aparna, Rolle, Chandra, Hansen, Baranda, Miller, Shondra, Obeng, Esther

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3220 – SF3B1/DNMT3A CO-MUTATION MIMICS FEATURES OF SOLE SF3B1 OR DNMT3A MUTATION DEPENDING ON STRESS CONDITIONS von Wallace, LaShanale, Cervantes, Ana Leal, Metidji, Amina, Myers, Jacquelyn, Campbell, Koral, Skorupa, Jordan, Fields, Henry, Rolle, Chandra, Tillman, Heather, Obeng, Esther

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Expression of mitochondrial genes MT-ND1, MT-ND6, MT-CYB, MT-COI, MT-ATP6, and 12S/MT-RNR1 in colorectal adenopolyps von Wallace, LaShanale, Mehrabi, Sharifeh, Bacanamwo, Methode, Yao, Xuebiao, Aikhionbare, Felix O.

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Selective Targeting of Splicing Factor Mutant Hematopoietic Stem and Progenitor Cells Via STAT3 Inhibition von Potts, Kathryn S, Cameron, Rosannah C., Ghazale, Noura, Gupta, Varun, Barajas, Juan Martin, Wallace, LaShanale, Leal-Cervantes, Ana, Aluri, Srinivas, Pradhan, Kith, McKinstry, Mia, Bai, Xiaoying, Choudhary, Gaurav S, Shastri, Aditi, Verma, Amit, Obeng, Esther A., Bowman, Teresa V.

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Abstract 5262: Specific mtDNA variants and colorectal adenopolyps von Wallace, LaShanale M., Mehrabi, Sharifeh, Yao, Xuebiao, Aikhionbare, Felix O.

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Abstract B55: Elevation of oxidative expression proteins in colorectal adenomatous polyps von Wallace, LaShanale M., Mehrabi, Sharifeh, Cohen, Shakeria, Aikhionbare, Felix O.

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3116 – SELECTIVE TARGETING OF SPLICING FACTOR MUTANT HEMATOPOIETIC STEM AND PROGENITOR CELLS VIA STAT3 INHIBITION von Potts, Kathryn, Cameron, Rosannah, Barajas, Juan, Cervantes, Ana Leal, Wallace, LaShanale, Gupta, Varun, Ghazale, Noura, Aluri, Srinivas, McKinstry, Mia, Bai, Xiaoying, Chaudhary, Gaurav, Shastri, Aditi, Verma, Amit, Obeng, Esther, Bowman, Teresa

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