The genetic architecture of multiple myeloma von Morgan, Gareth J., Walker, Brian A., Davies, Faith E.

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Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma von Weinhold, Niels, Ashby, Cody, Rasche, Leo, Chavan, Shweta S., Stein, Caleb, Stephens, Owen W., Tytarenko, Ruslana, Bauer, Michael A., Meissner, Tobias, Deshpande, Shayu, Patel, Purvi H., Buzder, Timea, Molnar, Gabor, Peterson, Erich A., van Rhee, Frits, Zangari, Maurizio, Thanendrarajan, Sharmilan, Schinke, Carolina, Tian, Erming, Epstein, Joshua, Barlogie, Bart, Davies, Faith E., Heuck, Christoph J., Walker, Brian A, Morgan, Gareth J.

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The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states von Rasche, Leo, Schinke, Carolina, Maura, Francesco, Bauer, Michael A., Ashby, Cody, Deshpande, Shayu, Poos, Alexandra M., Zangari, Maurizio, Thanendrarajan, Sharmilan, Davies, Faith E., Walker, Brian A., Barlogie, Bart, Landgren, Ola, Morgan, Gareth J., van Rhee, Frits, Weinhold, Niels

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The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma von Rasche, Leo, Angtuaco, Edgardo J., Alpe, Terri L., Gershner, Grant H., McDonald, James E., Samant, Rohan S., Kumar, Manoj, Van Hemert, Rudy, Epstein, Joshua, Deshpande, Shayu, Tytarenko, Ruslana, Yaccoby, Shmuel, Hillengass, Jens, Thanendrarajan, Sharmilan, Schinke, Carolina, van Rhee, Frits, Zangari, Maurizio, Walker, Brian A., Barlogie, Bart, Morgan, Gareth J., Davies, Faith E., Weinhold, Niels

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Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma von Kaiser, Martin F., Johnson, David C., Wu, Ping, Walker, Brian A., Brioli, Annamaria, Mirabella, Fabio, Wardell, Christopher P., Melchor, Lorenzo, Davies, Faith E., Morgan, Gareth J.

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Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition? von Pawlyn, Charlotte, Loehr, Andrea, Ashby, Cody, Tytarenko, Ruslana, Deshpande, Shayu, Sun, James, Fedorchak, Kyle, Mughal, Tariq, Davies, Faith E., Walker, Brian A., Morgan, Gareth J.

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Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma von Walker, Brian A., Wardell, Christopher P., Chiecchio, Laura, Smith, Emma M., Boyd, Kevin D., Neri, Antonino, Davies, Faith E., Ross, Fiona M., Morgan, Gareth J.

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Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly di... von Jones, John R, Weinhold, Niels, Ashby, Cody, Walker, Brian A, Wardell, Chris, Pawlyn, Charlotte, Rasche, Leo, Melchor, Lorenzo, Cairns, David A, Gregory, Walter M, Johnson, David, Begum, Dil B, Ellis, Sidra, Sherborne, Amy L, Cook, Gordon, Kaiser, Martin F, Drayson, Mark T, Owen, Roger G, Jackson, Graham H, Davies, Faith E, Greaves, Mel, Morgan, Gareth J

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Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors von Tornatore, Laura, Sandomenico, Annamaria, Raimondo, Domenico, Low, Caroline, Rocci, Alberto, Tralau-Stewart, Cathy, Capece, Daria, D’Andrea, Daniel, Bua, Marco, Boyle, Eileen, van Duin, Mark, Zoppoli, Pietro, Jaxa-Chamiec, Albert, Thotakura, Anil K., Dyson, Julian, Walker, Brian A., Leonardi, Antonio, Chambery, Angela, Driessen, Christoph, Sonneveld, Pieter, Morgan, Gareth, Palumbo, Antonio, Tramontano, Anna, Rahemtulla, Amin, Ruvo, Menotti, Franzoso, Guido

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1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma von Johnson, Travis S., Sudha, Parvathi, Liu, Enze, Becker, Nathan, Robertson, Sylvia, Blaney, Patrick, Morgan, Gareth, Chopra, Vivek S., Dos Santos, Cedric, Nixon, Michael, Huang, Kun, Suvannasankha, Attaya, Zaid, Mohammad Abu, Abonour, Rafat, Walker, Brian A.

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Differential RNA splicing as a potentially important driver mechanism in multiple myeloma von Bauer, Michael A., Ashby, Cody, Wardell, Christopher, Boyle, Eileen M., Ortiz, Maria, Flynt, Erin, Thakurta, Anjan, Morgan, Gareth, Walker, Brian A.

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The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma von Mikulasova, Aneta, Wardell, Christopher P, Murison, Alexander, Boyle, Eileen M, Jackson, Graham H, Smetana, Jan, Kufova, Zuzana, Pour, Ludek, Sandecka, Viera, Almasi, Martina, Vsianska, Pavla, Gregora, Evzen, Kuglik, Petr, Hajek, Roman, Davies, Faith E, Morgan, Gareth J, Walker, Brian A

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Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials von Danziger, Samuel A., McConnell, Mark, Gockley, Jake, Young, Mary H., Rosenthal, Adam, Schmitz, Frank, Reiss, David J., Farmer, Phil, Alapat, Daisy, Singh, Amrit, Ashby, Cody, Bauer, Michael, Ren, Yan, Smith, Kelsie, Couto, Suzana S., van Rhee, Frits, Davies, Faith, Zangari, Maurizio, Petty, Nathan, Orlowski, Robert Z., Dhodapkar, Madhav, Copeland, Wilbert B., Fox, Brian, Hoering, Antje, Fitch, Alison, Newhall, Katie, Barlogie, Bart, Trotter, Matthew W. B., Hershberg, Robert M., Walker, Brian A., Dervan, Andrew P., Ratushny, Alexander, Morgan, Gareth J.

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Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells von Walker, Brian A., Wardell, Christopher P., Johnson, David C., Kaiser, Martin F., Begum, Dil B., Dahir, Nasrin B., Ross, Fiona M., Davies, Faith E., Gonzalez, David, Morgan, Gareth J.

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Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma von Mikulasova, Aneta, Ashby, Cody, Tytarenko, Ruslana G., Qu, Pingping, Rosenthal, Adam, Dent, Judith A., Ryan, Katie R., Bauer, Michael A., Wardell, Christopher P., Hoering, Antje, Mavrommatis, Konstantinos, Trotter, Matthew, Deshpande, Shayu, Yaccoby, Shmuel, Tian, Erming, Keats, Jonathan, Auclair, Daniel, Jackson, Graham H., Davies, Faith E., Thakurta, Anjan, Morgan, Gareth J., Walker, Brian A.

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The level of deletion 17p and bi-allelic inactivation of TP53 has a significant impact on clinical outcome in multiple myeloma von Thanendrarajan, Sharmilan, Tian, Erming, Qu, Pingping, Mathur, Pankaj, Schinke, Carolina, van Rhee, Frits, Zangari, Maurizio, Rasche, Leo, Weinhold, Niels, Alapat, Daisy, Bellamy, William, Ashby, Cody, Mattox, Sandra, Epstein, Joshua, Yaccoby, Shmuel, Barlogie, Bart, Hoering, Antje, Bauer, Michael, Walker, Brian A, Davies, Faith E, Morgan, Gareth J

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Long-term outcomes after autologous stem cell transplantation for multiple myeloma von Nishimura, Katherine K., Barlogie, Bart, van Rhee, Frits, Zangari, Maurizio, Walker, Brian A., Rosenthal, Adam, Schinke, Carolina, Thanendrarajan, Sharmilan, Davies, Faith E., Hoering, Antje, Morgan, Gareth J.

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Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma von Nguyen, Hong Phuong, Le, Anh Quynh, Liu, Enze, Cesarano, Annamaria, DiMeo, Francesco, Perna, Fabiana, Kapur, Reuben, Walker, Brian A, Tran, Ngoc Tung

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MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma von Qiang, Ya-Wei, Ye, Shiqiao, Huang, Yuhua, Chen, Yu, Van Rhee, Frits, Epstein, Joshua, Walker, Brian A, Morgan, Gareth J, Davies, Faith E

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Corrigendum: Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma von Nguyen, Hong Phuong, Le, Anh Quynh, Liu, Enze, Cesarano, Annamaria, DiMeo, Francesco, Perna, Fabiana, Kapur, Reuben, Walker, Brian A., Tran, Ngoc Tung

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