Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices von Bird, Gregory H, Mazzola, Emanuele, Opoku-Nsiah, Kwadwo, Lammert, Margaret A, Godes, Marina, Neuberg, Donna S, Walensky, Loren D

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The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members von Verdine, Gregory L, Walensky, Loren D

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Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer von Kim, Woojin, Bird, Gregory H, Neff, Tobias, Guo, Guoji, Kerenyi, Marc A, Walensky, Loren D, Orkin, Stuart H

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer von Walensky, Loren D, Stewart, Michelle L, Fire, Emiko, Keating, Amy E

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BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX von Gavathiotis, Evripidis, Reyna, Denis E., Davis, Marguerite L., Bird, Gregory H., Walensky, Loren D.

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Targeting BAX to drug death directly von Walensky, Loren D.

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Direct activation of full-length proapoptotic BAK von Leshchiner, Elizaveta S, Braun, Craig R, Bird, Gregory H, Walensky, Loren D

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Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices von Leshchiner, Elizaveta S., Parkhitko, Andrey, Bird, Gregory H., Luccarelli, James, Bellairs, Joseph A., Escudero, Silvia, Opoku-Nsiah, Kwadwo, Godes, Marina, Perrimon, Norbert, Walensky, Loren D.

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Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism von Barclay, Lauren A., Wales, Thomas E., Garner, Thomas P., Wachter, Franziska, Lee, Susan, Guerra, Rachel M., Stewart, Michelle L., Braun, Craig R., Bird, Gregory H., Gavathiotis, Evripidis, Engen, John R., Walensky, Loren D.

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BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress von Carpio, Marcos A., Michaud, Michael, Zhou, Wenping, Fisher, Jill K., Walensky, Loren D., Katz, Samuel G.

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Direct and selective small-molecule activation of proapoptotic BAX von Gavathiotis, Evripidis, Reyna, Denis E, Bellairs, Joseph A, Leshchiner, Elizaveta S, Walensky, Loren D

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Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide von Bernal, Federico, Tyler, Andrew F, Korsmeyer, Stanley J, Walensky, Loren D, Verdine, Gregory L

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Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic von Bird, Gregory H., Madani, Navid, Perry, Alisa F., Princiotto, Amy M., Supko, Jeffrey G., He, Xiaoying, Gavathiotis, Evripidis, Sodroski, Joseph G., Walensky, Loren D., Snyder, Solomon H.

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The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core von Bloch, Noah B., Wales, Thomas E., Prew, Michelle S., Levy, Hannah R., Engen, John R., Walensky, Loren D.

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BAX activation is initiated at a novel interaction site von Tjandra, Nico, Walensky, Loren D, Gavathiotis, Evripidis, Suzuki, Motoshi, Davis, Marguerite L, Pitter, Kenneth, Bird, Gregory H, Katz, Samuel G, Tu, Ho-Chou, Kim, Hyungjin, Cheng, Emily H.-Y

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From Mitochondrial Biology to Magic Bullet: Navitoclax Disarms BCL-2 in Chronic Lymphocytic Leukemia von WALENSKY, Loren D

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Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors von Huhn, Annissa J., Guerra, Rachel M., Harvey, Edward P., Bird, Gregory H., Walensky, Loren D.

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Hydrocarbon-stapled peptides: principles, practice, and progress von Walensky, Loren D, Bird, Gregory H

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The retinoblastoma protein induces apoptosis directly at the mitochondria von Hilgendorf, Keren I, Leshchiner, Elizaveta S, Nedelcu, Simona, Maynard, Mindy A, Calo, Eliezer, Ianari, Alessandra, Walensky, Loren D, Lees, Jacqueline A

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Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix von Walensky, Loren D., Kung, Andrew L., Escher, Iris, Malia, Thomas J., Barbuto, Scott, Wright, Renee D., Wagner, Gerhard, Verdine, Gregory L., Korsmeyer, Stanley J.

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