Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing von Prystaz, Katja, Kaiser, Kathrin, Kovtun, Anna, Haffner-Luntzer, Melanie, Fischer, Verena, Rapp, Anna E., Liedert, Astrid, Strauss, Gudrun, Waetzig, Georg H., Rose-John, Stefan, Ignatius, Anita

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Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells von Lokau, Juliane, Kleinegger, Florian, Garbers, Yvonne, Waetzig, Georg H., Groetzinger, Joachim, Rose-John, Stefan, Haybaeck, Johannes, Garbers, Christoph

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Inhibition of IL‐6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer von Goumas, Freya A., Holmer, Reinhild, Egberts, Jan‐Hendrik, Gontarewicz, Artur, Heneweer, Carola, Geisen, Ulf, Hauser, Charlotte, Mende, Maria‐Margarete, Legler, Karen, Röcken, Christoph, Becker, Thomas, Waetzig, Georg H., Rose‐John, Stefan, Kalthoff, Holger

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Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice von Schuett, Harald, Oestreich, René, Waetzig, Georg H, Annema, Wijtske, Luchtefeld, Maren, Hillmer, Anja, Bavendiek, Udo, von Felden, Johann, Divchev, Dimitar, Kempf, Tibor, Wollert, Kai C, Seegert, Dirk, Rose-John, Stefan, Tietge, Uwe J.F, Schieffer, Bernhard, Grote, Karsten

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Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans von Fangmann, Daniela, Theismann, Eva-Maria, Türk, Kathrin, Schulte, Dominik M, Relling, Isabelle, Hartmann, Katharina, Keppler, Julia K, Knipp, Jörg-Rainer, Rehman, Ateequr, Heinsen, Femke-Anouska, Franke, Andre, Lenk, Lennart, Freitag-Wolf, Sandra, Appel, Esther, Gorb, Stanislav, Brenner, Charles, Seegert, Dirk, Waetzig, Georg H, Rosenstiel, Philip, Schreiber, Stefan, Schwarz, Karin, Laudes, Matthias

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An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer von Garbers, Christoph, Spudy, Björn, Aparicio-Siegmund, Samadhi, Waetzig, Georg H., Sommer, Jan, Hölscher, Christoph, Rose-John, Stefan, Grötzinger, Joachim, Lorenzen, Inken, Scheller, Jürgen

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Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma von Kaiser, Kathrin, Prystaz, Katja, Vikman, Anna, Haffner-Luntzer, Melanie, Bergdolt, Stephanie, Strauss, Gudrun, Waetzig, Georg H., Rose-John, Stefan, Ignatius, Anita

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Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor von Garbers, Christoph, Thaiss, Wolfgang, Jones, Gareth W., Waetzig, Georg H., Lorenzen, Inken, Guilhot, Florence, Lissilaa, Rami, Ferlin, Walter G., Grötzinger, Joachim, Jones, Simon A., Rose-John, Stefan, Scheller, Jürgen

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A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor von Düsterhöft, Stefan, Höbel, Katharina, Oldefest, Mirja, Lokau, Juliane, Waetzig, Georg H., Chalaris, Athena, Garbers, Christoph, Scheller, Jürgen, Rose-John, Stefan, Lorenzen, Inken, Grötzinger, Joachim

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Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model von Barkhausen, Tanja, Tschernig, Thomas, Rosenstiel, Philip, van Griensven, Martijn, Vonberg, Ralf-Peter, Dorsch, Martina, Mueller-Heine, Annika, Chalaris, Athena, Scheller, Jürgen, Rose-John, Stefan, Seegert, Dirk, Krettek, Christian, Waetzig, Georg H

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Transgenic blockade of interleukin 6 transsignaling abrogates inflammation von Rabe, Björn, Chalaris, Athena, May, Ulrike, Waetzig, Georg H., Seegert, Dirk, Williams, Anwen S., Jones, Simon A., Rose-John, Stefan, Scheller, Jürgen

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Interleukin-6: a villain in the drama of pancreatic cancer development and progression von Holmer, Reinhild, Goumas, Freya A, Waetzig, Georg H, Rose-John, Stefan, Kalthoff, Holger

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Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases von Nikolaus, Susanna, Waetzig, Georg H., Butzin, Sven, Ziolkiewicz, Monika, Al-Massad, Natalie, Thieme, Florian, Lövgren, Ulf, Rasmussen, Birgitte B., Reinheimer, Torsten M., Seegert, Dirk, Rosenstiel, Philip, Szymczak, Silke, Schreiber, Stefan

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Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice von Agthe, Maria, Brügge, Julian, Garbers, Yvonne, Wandel, Marieke, Kespohl, Birte, Arnold, Philipp, Flynn, Charlotte M., Lokau, Juliane, Aparicio-Siegmund, Samadhi, Bretscher, Christian, Rose-John, Stefan, Waetzig, Georg H., Putoczki, Tracy, Grötzinger, Joachim, Garbers, Christoph

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Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium Difficile Infection von Ott, Stephan J, Waetzig, Georg H, Rehman, Ateequr, Moltzau-Anderson, Jacqueline, Bharti, Richa, Grasis, Juris A, Cassidy, Liam, Tholey, Andreas, Fickenscher, Helmut, Seegert, Dirk, Rosenstiel, Philip, Schreiber, Stefan

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A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing von Wolf, Janina, Waetzig, Georg H., Reinheimer, Torsten M., Scheller, Jürgen, Rose-John, Stefan, Garbers, Christoph

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Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases von Nikolaus, Susanna, Schulte, Berenice, Al-Massad, Natalie, Thieme, Florian, Schulte, Dominik M., Bethge, Johannes, Rehman, Ateequr, Tran, Florian, Aden, Konrad, Häsler, Robert, Moll, Natalie, Schütze, Gregor, Schwarz, Markus J., Waetzig, Georg H., Rosenstiel, Philip, Krawczak, Michael, Szymczak, Silke, Schreiber, Stefan

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Cardiovascular safety of vitamin B3 administration von Schreiber, Stefan, Waetzig, Georg H., Laudes, Matthias, Rosenstiel, Philip

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The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling von Baran, Paul, Hansen, Selina, Waetzig, Georg H., Akbarzadeh, Mohammad, Lamertz, Larissa, Huber, Heinrich J., Ahmadian, M. Reza, Moll, Jens M., Scheller, Jürgen

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Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases von Aden, Konrad, Rehman, Ateequr, Waschina, Silvio, Pan, Wei-Hung, Walker, Alesia, Lucio, Marianna, Nunez, Alejandro Mena, Bharti, Richa, Zimmerman, Johannes, Bethge, Johannes, Schulte, Berenice, Schulte, Dominik, Franke, Andre, Nikolaus, Susanna, Schroeder, Johann Oltmann, Vandeputte, Doris, Raes, Jeroen, Szymczak, Silke, Waetzig, Georg H., Zeuner, Rainald, Schmitt-Kopplin, Philippe, Kaleta, Christoph, Schreiber, Stefan, Rosenstiel, Philip

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