HIV capsid is a tractable target for small molecule therapeutic intervention von Blair, Wade S, Pickford, Chris, Irving, Stephen L, Brown, David G, Anderson, Marie, Bazin, Richard, Cao, Joan, Ciaramella, Giuseppe, Isaacson, Jason, Jackson, Lynn, Hunt, Rachael, Kjerrstrom, Anne, Nieman, James A, Patick, Amy K, Perros, Manos, Scott, Andrew D, Whitby, Kevin, Wu, Hua, Butler, Scott L

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HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys von Moldt, Brian, Chandrashekar, Abishek, Borducchi, Erica N, Nkolola, Joseph P, Stephenson, Heather, Nagel, Mark, Hung, Magdeleine, Goldsmith, Joshua, Pace, Craig S, Carr, Brian, Thomsen, Nathan D, Blair, Wade S, Geleziunas, Romas, Barouch, Dan H

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Doravirine Suppresses Common Nonnucleoside Reverse Transcriptase Inhibitor-Associated Mutants at Clinically Relevant Concentrations von Feng, Meizhen, Sachs, Nancy A, Xu, Min, Grobler, Jay, Blair, Wade, Hazuda, Daria J, Miller, Michael D, Lai, Ming-Tain

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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors von Sohn, Sue J, Barrett, Kathy, Van Abbema, Anne, Chang, Christine, Kohli, Pawan Bir, Kanda, Hidenobu, Smith, Janice, Lai, Yingjie, Zhou, Aihe, Zhang, Birong, Yang, Wenqian, Williams, Karen, Macleod, Calum, Hurley, Christopher A, Kulagowski, Janusz J, Lewin-Koh, Nicholas, Dengler, Hart S, Johnson, Adam R, Ghilardi, Nico, Zak, Mark, Liang, Jun, Blair, Wade S, Magnuson, Steven, Wu, Lawren C

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Lead identification of novel and selective TYK2 inhibitors von Liang, Jun, Tsui, Vickie, Van Abbema, Anne, Bao, Liang, Barrett, Kathy, Beresini, Maureen, Berezhkovskiy, Leo, Blair, Wade S., Chang, Christine, Driscoll, James, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Halladay, Jason, Johnson, Adam, Kohli, Pawan Bir, Lai, Yingjie, Liimatta, Marya, Mantik, Priscilla, Menghrajani, Kapil, Murray, Jeremy, Sambrone, Amy, Xiao, Yisong, Shia, Steven, Shin, Young, Smith, Jan, Sohn, Sue, Stanley, Mark, Ultsch, Mark, Zhang, Birong, Wu, Lawren C., Magnuson, Steven

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A broadly neutralizing human monoclonal antibody directed against a novel conserved epitope on the influenza virus H3 hemagglutinin globular head von Benjamin, Ebony, Wang, Weijia, McAuliffe, Josephine M, Palmer-Hill, Frances J, Kallewaard, Nicole L, Chen, Zhongying, Suzich, JoAnn A, Blair, Wade S, Jin, Hong, Zhu, Qing

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Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors von Hanan, Emily J, van Abbema, Anne, Barrett, Kathy, Blair, Wade S, Blaney, Jeff, Chang, Christine, Eigenbrot, Charles, Flynn, Sean, Gibbons, Paul, Hurley, Christopher A, Kenny, Jane R, Kulagowski, Janusz, Lee, Leslie, Magnuson, Steven R, Morris, Claire, Murray, Jeremy, Pastor, Richard M, Rawson, Tom, Siu, Michael, Ultsch, Mark, Zhou, Aihe, Sampath, Deepak, Lyssikatos, Joseph P

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Current Landscape of Antiviral Drug Discovery von Blair, Wade, Cox, Christopher

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A survey of core replacements in indole-based HIV-1 attachment inhibitors von Wang, Tao, Wallace, Owen B., Zhang, Zhongxing, Fang, Haiquan, Yang, Zhong, Robinson, Brett A., Spicer, Timothy P., Gong, Yi-Fei, Blair, Wade S., Shi, Pei-Yong, Lin, Pin-Fang, Deshpande, Milind, Meanwell, Nicholas A., Kadow, John F.

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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors von Siu, Michael, Pastor, Richard, Liu, Wendy, Barrett, Kathy, Berry, Megan, Blair, Wade S., Chang, Christine, Chen, Jacob Z., Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, He, Haiying, Hurley, Christopher A., Kenny, Jane R., Cyrus Khojasteh, S., Le, Hoa, Lee, Leslie, Lyssikatos, Joseph P., Magnuson, Steve, Pulk, Rebecca, Tsui, Vickie, Ultsch, Mark, Xiao, Yisong, Zhu, Bing-yan, Sampath, Deepak

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Infection and Propagation of Human Rhinovirus C in Human Airway Epithelial Cells von WEIDONG HAO, BERNARD, Katie, BLAIR, Wade, QING ZHU, PATEL, Nita, ULBRANDT, Nancy, HUI FENG, SVABEK, Catherine, WILSON, Susan, STRACENER, Christina, WANG, Kathy, SUZICH, Joann

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Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor von Shi, Jiong, Zhou, Jing, Halambage, Upul D, Shah, Vaibhav B, Burse, Mallori J, Wu, Hua, Blair, Wade S, Butler, Scott L, Aiken, Christopher

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Lead Optimization of a 4‑Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors von Liang, Jun, van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade, Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Halladay, Jason, Johnson, Adam, Kohli, Pawan Bir, Lai, Yingjie, Liu, Yanzhou, Lyssikatos, Joseph, Mantik, Priscilla, Menghrajani, Kapil, Murray, Jeremy, Peng, Ivan, Sambrone, Amy, Shia, Steven, Shin, Young, Smith, Jan, Sohn, Sue, Tsui, Vickie, Ultsch, Mark, Wu, Lawren C, Xiao, Yisong, Yang, Wenqian, Young, Judy, Zhang, Birong, Zhu, Bing-yan, Magnuson, Steven

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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model von Liang, Jun, Van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade S., Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Goodacre, Simon, Ghilardi, Nico, MacLeod, Calum, Johnson, Adam, Bir Kohli, Pawan, Lai, Yingjie, Lin, Zhonghua, Mantik, Priscilla, Menghrajani, Kapil, Nguyen, Hieu, Peng, Ivan, Sambrone, Amy, Shia, Steven, Smith, Jan, Sohn, Sue, Tsui, Vickie, Ultsch, Mark, Williams, Karen, Wu, Lawren C., Yang, Wenqian, Zhang, Birong, Magnuson, Steven

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New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation von BLAIR, Wade S, CAO, Joan, PICKFORD, Chris, HUA WU, BUTLER, Scott L, FOK-SEANG, Juin, GRIFFIN, Paul, ISAACSON, Jason, LYNN JACKSON, R, MURRAY, Edward, PATRICK, Amy K, QINGHAI PENG, PERROS, Manos

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Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2 von Zak, Mark, Hurley, Christopher A, Ward, Stuart I, Bergeron, Philippe, Barrett, Kathy, Balazs, Mercedesz, Blair, Wade S, Bull, Richard, Chakravarty, Paroma, Chang, Christine, Crackett, Peter, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ellwood, Charles, Gaines, Simon, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Gribling, Peter, Hamman, Chris, Harstad, Eric, Hewitt, Peter, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Labadie, Sharada, Lee, Wyne P, Liao, Jiangpeng, Liimatta, Marya, Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Reeve, Austin, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, van Abbema, Anne, Aliagas, Ignacio, Avitabile-Woo, Barbara, Xiao, Yisong, Yang, Jing, Kulagowski, Janusz J

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Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors von Labadie, Sharada, Barrett, Kathy, Blair, Wade S., Chang, Christine, Deshmukh, Gauri, Eigenbrot, Charles, Gibbons, Paul, Johnson, Adam, Kenny, Jane R., Kohli, Pawan Bir, Liimatta, Marya, Lupardus, Patrick J., Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Abbema, Anne van, Zak, Mark

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Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys von Boopathy, Archana V., Sharma, Bhawna, Nekkalapudi, Anurag, Wimmer, Raphaela, Gamez-Guerrero, Maria, Suthram, Silpa, Truong, Hoa, Lee, Johnny, Li, Jiani, Martin, Ross, Blair, Wade, Geleziunas, Romas, Orlinger, Klaus, Ahmadi-Erber, Sarah, Lauterbach, Henning, Makadzange, Tariro, Falkard, Brie, Schmidt, Sarah

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Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates von Sharma, Bhawna, Bekerman, Elena, Truong, Hoa, Lee, Johnny, Gamez-Guerrero, Maria, Boopathy, Archana, Mital, Rohit, Huang, Katell Bidet, Ahmadi-Erber, Sarah, Wimmer, Raphaela, Schulha, Sophie, Lauterbach, Henning, Orlinger, Klaus, Suthram, Silpa, Lewis, Mark G, Blair, Wade, Makadzange, Tariro, Geleziunas, Romas, Murry, Jeffrey P, Schmidt, Sarah

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A Small Molecule HIV-1 Inhibitor That Targets the HIV-1 Envelope and Inhibits CD4 Receptor Binding von Lin, Pin-Fang, Blair, Wade, Wang, Tao, Spicer, Timothy, Guo, Qi, Zhou, Nannan, Gong, Yi-Fei, H. -G. Heidi Wang, Rose, Ronald, Yamanaka, Gregory, Robinson, Brett, Li, Chang-Ben, Fridell, Robert, Deminie, Carol, Demers, Gwendeline, Yang, Zheng, Zadjura, Lisa, Meanwell, Nicholas, Colonno, Richard

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