Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials von Egen, Jackson G., Ouyang, Wenjun, Wu, Lawren C.

Volltext

Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer von Hughes, Paul E, Caenepeel, Sean, Wu, Lawren C

Volltext

The production and regulation of IgE by the immune system von Wu, Lawren C., Zarrin, Ali A.

Volltext

Targeting IgE production in mice and humans von Wu, Lawren C, Scheerens, Heleen

Volltext

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients von Jia, Guiquan, MD, Erickson, Richard W., BS, Choy, David F., BS, Mosesova, Sofia, PhD, Wu, Lawren C., PhD, Solberg, Owen D., PhD, Shikotra, Aarti, BSc, Carter, Richard, MRCP, Audusseau, Séverine, MSc, Hamid, Qutayba, MD, PhD, Bradding, Peter, DM, FRCP, Fahy, John V., MD, MSc, Woodruff, Prescott G., MD, MPH, Harris, Jeffrey M., MD, PhD, Arron, Joseph R., MD, PhD

Volltext

Immunoglobulin E Receptor Signaling and Asthma von Wu, Lawren C.

Volltext

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab von Ultsch, Mark, Bevers, Jack, Nakamura, Gerald, Vandlen, Richard, Kelley, Robert F., Wu, Lawren C., Eigenbrot, Charles

Volltext

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma von Shikotra, Aarti, BSc, Choy, David F., BSc, Ohri, Chandra M., MD, Doran, Emma, BSc, Butler, Claire, MBBCh, Hargadon, Beverley, BSc, Shelley, Maria, BA, Abbas, Alexander R., PhD, Austin, Cary D., MD, PhD, Jackman, Janet, MSc, Wu, Lawren C., PhD, Heaney, Liam G., MD, Arron, Joseph R., MD, PhD, Bradding, Peter, DM

Volltext

Lebrikizumab Treatment in Adults with Asthma von Corren, Jonathan, Lemanske, Robert F, Hanania, Nicola A, Korenblat, Phillip E, Parsey, Merdad V, Arron, Joseph R, Harris, Jeffrey M, Scheerens, Heleen, Wu, Lawren C, Su, Zheng, Mosesova, Sofia, Eisner, Mark D, Bohen, Sean P, Matthews, John G

Volltext

IgE+ memory B cells and plasma cells generated through a germinal-center pathway von Talay, Oezcan, Yan, Donghong, Brightbill, Hans D, Straney, Elizabeth E M, Zhou, Meijuan, Ladi, Ena, Lee, Wyne P, Egen, Jackson G, Austin, Cary D, Xu, Min, Wu, Lawren C

Volltext

Autonomous IL-36R signaling in neutrophils activates potent antitumor effector functions von Roy, Sumedha, Fitzgerald, Karen, Lalani, Almin, Lai, Chin-Wen, Kim, Aeryon, Kim, Jennie, Ou, Peiqi, Mirsoian, Annie, Liu, Xian, Ramrakhiani, Ambika, Zhao, Huiren, Zhou, Hong, Xu, Haoda, Meisen, Hans, Li, Chi-Ming, Lugt, Bryan Vander, Thibault, Steve, Tinberg, Christine E, DeVoss, Jason, Egen, Jackson, Wu, Lawren C, Noubade, Rajkumar

Volltext

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

Volltext

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways von Choy, David F, Modrek, Barmak, Abbas, Alexander R, Kummerfeld, Sarah, Clark, Hilary F, Wu, Lawren C, Fedorowicz, Grazyna, Modrusan, Zora, Fahy, John V, Woodruff, Prescott G, Arron, Joseph R

Volltext

Preparing for a career in biopharma research von Wu, Lawren C

Volltext

A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors von Sohn, Sue J, Barrett, Kathy, Van Abbema, Anne, Chang, Christine, Kohli, Pawan Bir, Kanda, Hidenobu, Smith, Janice, Lai, Yingjie, Zhou, Aihe, Zhang, Birong, Yang, Wenqian, Williams, Karen, Macleod, Calum, Hurley, Christopher A, Kulagowski, Janusz J, Lewin-Koh, Nicholas, Dengler, Hart S, Johnson, Adam R, Ghilardi, Nico, Zak, Mark, Liang, Jun, Blair, Wade S, Magnuson, Steven, Wu, Lawren C

Volltext

Dendritic cells require NIK for CD40-dependent cross-priming of CD8⁺ T cells von Katakam, Anand K., Brightbill, Hans, Franci, Christian, Kung, Chung, Nunez, Victor, Jones, Charles, Peng, Ivan, Jeet, Surinder, Wu, Lawren C., Mellman, Ira, Delamarre, Lélia, Austin, Cary D.

Volltext

Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses von Li, Yanchuan, Wang, Hui, Zhou, Xiaofei, Xie, Xiaoping, Chen, Xiang, Jie, Zuliang, Zou, Qiang, Hu, Hongbo, Zhu, Lele, Cheng, Xuhong, Brightbill, Hans D, Wu, Lawren C., Wang, Linfang, Sun, Shao-Cong

Volltext

Lead identification of novel and selective TYK2 inhibitors von Liang, Jun, Tsui, Vickie, Van Abbema, Anne, Bao, Liang, Barrett, Kathy, Beresini, Maureen, Berezhkovskiy, Leo, Blair, Wade S., Chang, Christine, Driscoll, James, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Halladay, Jason, Johnson, Adam, Kohli, Pawan Bir, Lai, Yingjie, Liimatta, Marya, Mantik, Priscilla, Menghrajani, Kapil, Murray, Jeremy, Sambrone, Amy, Xiao, Yisong, Shia, Steven, Shin, Young, Smith, Jan, Sohn, Sue, Stanley, Mark, Ultsch, Mark, Zhang, Birong, Wu, Lawren C., Magnuson, Steven

Volltext

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase von Blaquiere, Nicole, Castanedo, Georgette M, Burch, Jason D, Berezhkovskiy, Leonid M, Brightbill, Hans, Brown, Suzanne, Chan, Connie, Chiang, Po-Chang, Crawford, James J, Dong, Teresa, Fan, Peter, Feng, Jianwen, Ghilardi, Nico, Godemann, Robert, Gogol, Emily, Grabbe, Alice, Hole, Alison J, Hu, Baihua, Hymowitz, Sarah G, Alaoui Ismaili, Moulay Hicham, Le, Hoa, Lee, Patrick, Lee, Wyne, Lin, Xingyu, Liu, Ning, McEwan, Paul A, McKenzie, Brent, Silvestre, Hernani L, Suto, Eric, Sujatha-Bhaskar, Swathi, Wu, Guosheng, Wu, Lawren C, Zhang, Yamin, Zhong, Zoe, Staben, Steven T

Volltext

Lead Optimization of a 4‑Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors von Liang, Jun, van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade, Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Halladay, Jason, Johnson, Adam, Kohli, Pawan Bir, Lai, Yingjie, Liu, Yanzhou, Lyssikatos, Joseph, Mantik, Priscilla, Menghrajani, Kapil, Murray, Jeremy, Peng, Ivan, Sambrone, Amy, Shia, Steven, Shin, Young, Smith, Jan, Sohn, Sue, Tsui, Vickie, Ultsch, Mark, Wu, Lawren C, Xiao, Yisong, Yang, Wenqian, Young, Judy, Zhang, Birong, Zhu, Bing-yan, Magnuson, Steven

Volltext