LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys von Adams, Andrew C, Halstead, Carolyn A, Hansen, Barbara C, Irizarry, Armando R, Martin, Jennifer A, Myers, Sharon R, Reynolds, Vincent L, Smith, Holly W, Wroblewski, Victor J, Kharitonenkov, Alexei

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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 von Kharitonenkov, Alexei, Beals, John M, Micanovic, Radmila, Strifler, Beth A, Rathnachalam, Radhakrishnan, Wroblewski, Victor J, Li, Shun, Koester, Anja, Ford, Amy M, Coskun, Tamer, Dunbar, James D, Cheng, Christine C, Frye, Christopher C, Bumol, Thomas F, Moller, David E

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Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics von Datta-Mannan, Amita, Thangaraju, Arunkumar, Leung, Donmienne, Tang, Ying, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J

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Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications von Theurl, Igor, Aigner, Elmar, Theurl, Milan, Nairz, Manfred, Seifert, Markus, Schroll, Andrea, Sonnweber, Thomas, Eberwein, Lukas, Witcher, Derrick R., Murphy, Anthony T., Wroblewski, Victor J., Wurz, Eva, Datz, Christian, Weiss, Guenter

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The Metabolic State of Diabetic Monkeys Is Regulated by Fibroblast Growth Factor-21 von Kharitonenkov, Alexei, Wroblewski, Victor J, Koester, Anja, Chen, Yun-Fei, Clutinger, Cathleen K, Tigno, Xenia T, Hansen, Barbara C, Shanafelt, Armen B, Etgen, Garret J

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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies von Datta-Mannan, Amita, Lu, Jirong, Witcher, Derrick R, Leung, Donmienne, Tang, Ying, Wroblewski, Victor J

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Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model von Vermeersch, Steve, Benschop, Robert J., Van Hecken, Anne, Monteith, David, Wroblewski, Victor J., Grayzel, David, de Hoon, Jan, Collins, Emily C.

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Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys von Datta-Mannan, Amita, Croy, Johnny E, Schirtzinger, Linda, Torgerson, Stacy, Breyer, Matthew, Wroblewski, Victor J

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Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry von Murphy, Anthony T., Witcher, Derrick R., Luan, Peng, Wroblewski, Victor J.

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In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS von Huang, Lihua, Lu, Jirong, Wroblewski, Victor J, Beals, John M, Riggin, Ralph M

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Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S] von Schroeder, Krista M., Beyer, Thomas P., Hansen, Ryan J., Han, Bomie, Pickard, Richard T., Wroblewski, Victor J., Kowala, Mark C., Eacho, Patrick I.

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Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587 von Peng, Sheng-Bin, Van Horn, Robert D, Yin, Tinggui, Brown, Robin M, Roell, William C, Obungu, Victor H, Ruegg, Charles, Wroblewski, Victor J, Raddad, Eyas, Stille, John R

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FcRn Affinity-Pharmacokinetic Relationship of Five Human IgG4 Antibodies Engineered for Improved In Vitro FcRn Binding Properties in Cynomolgus Monkeys von Datta-Mannan, Amita, Chow, Chi-Kin, Dickinson, Craig, Driver, David, Lu, Jirong, Witcher, Derrick R., Wroblewski, Victor J.

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Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting von Smith, Rosamund C, Cramer, Martin S, Mitchell, Pamela J, Capen, Andrew, Huber, Lysiane, Wang, Rong, Myers, Laura, Jones, Bryan E, Eastwood, Brian J, Ballard, Darryl, Hanson, Jeff, Credille, Kelly M, Wroblewski, Victor J, Lin, Boris K, Heuer, Josef G

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Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells von Goebl, Nancy A, Babbey, Clifford M, Datta-Mannan, Amita, Witcher, Derrick R, Wroblewski, Victor J, Dunn, Kenneth W

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Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys von Datta-Mannan, Amita, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J

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Peripheral and central nervous system distribution of the CGRP neutralizing antibody [125I] galcanezumab in male rats von Johnson, Kirk W, Morin, S Michelle, Wroblewski, Victor J, Johnson, Michael P

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A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets von Rhoden, John J., Dyas, Gregory L., Wroblewski, Victor J.

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Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency von Finkenstedt, Armin, Bianchi, Paola, Theurl, Igor, Vogel, Wolfgang, Witcher, Derrick R., Wroblewski, Victor J., Murphy, Anthony T., Zanella, Alberto, Zoller, Heinz

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Application of FcRn binding assays to guide mAb development von Datta-Mannan, Amita, Wroblewski, Victor J

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